Pathophysiological model of chronic heart failure complicated with renal failure caused by three-quarter nephrectomy and subcutaneous injection of isoprenaline

Peng, Dan; Tang, Shaoyong; Hu, Yongjun; Chen, Jiao; Yang, Li

doi:10.3892/etm.2012.865

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…One of the expected physiological consequences of HF is the reduction of urinary volume, a significant marker of renal dysfunction, a pathophysiological context involved in the cardiorenal syndrome (19,20). Therefore, our results show that the groups induced to HF showed a marked reduction in the urinary parameters analyzed (Figures 5, 6 and 7), and these results have already been exposed and discussed in previous studies (21,22). Thus, the observed results are in agreement with the literature.…”

Section: Discussionsupporting

confidence: 92%

Pharmacological Profile of Loop Diuretic in Experimental Model of Heart Failure

Moura¹,

Mendes²,

Oliveira³

et al. 2022

JHS

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Loop diuretics such as furosemide are first-line drugs for patients with decompensated heart failure (HF). The study aims to describe the implementation and standardization of an experimental model in diuresis at the Laboratory of Research and Graduate Studies in Pharmacology at the Federal University of Maranhão. Rats were randomly divided: furosemide (furosemide) group received 10 mg/kg furosemide, without CI; The Heart Failure Group (Vehicle-HF) received 10ml/kg of water and the Heart Failure-Furosemide Group (Furosemide-HF) received 10mg/kg of furosemide. IC was induced by isoproterenol for seven days. Oral treatment took place for 7 days to assess food and water intake, weight gain, urinary volume, excretion and diuretic activity. The rodents with HF showed cardiac hypertrophy and body weight loss in the induction process.Regarding the impacts of HF on water consumption, the animals with heart disease showed intense water intake compared to the Furosemide Group. During treatment, there was a significant drop in water consumption in these groups, a change that is not evident on the last day of treatment among the groups evaluated. There was no change in feed consumption. The HF-vehicle and HFfurosemide groups showed a reduction in 24hour urinary volume, urinary excretion and diuresis, on the 7th day of treatment, when compared to the healthy group, treated with the diuretic. The results allow to identify the deleterious impacts of the induction of CI on the renal capacity of the animals, reducing the urinary volume and urinary excretion, where the diuretic activity of furosemide was compromised without it being able to induce with the expected effectiveness, its activity on the animal renal system. The data studied identified patterns in the diuresis protocol in animals with heart failure, with possibilities for future pharmacological investigations.

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Section: Discussionsupporting

confidence: 92%

Pharmacological Profile of Loop Diuretic in Experimental Model of Heart Failure

Moura¹,

Mendes²,

Oliveira³

et al. 2022

JHS

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“…We also examined the serum levels of BNP for each treatment. BNP is a natriuretic peptide that regulates a spectrum of physiological and pathophysiological activities by decreasing cardiorenal filling overload (20). BNP is secreted by atrial myocytes under normal conditions.…”

Section: Discussionmentioning

confidence: 99%

“…BNP levels were measured to assess the severity of heart failure (20) and were calculated by analyzing blood samples from every animal in each group at week 6. BNP levels were measured using the mouse BNP enzyme-linked immunosorbent assay kit (Wuhan EIAab Science Co., Ltd., Wuhan, China) according to the manufacturer's instructions.…”

Section: Assay For Serum Brain Natriuretic Peptide (Bnp)mentioning

confidence: 99%

Protective effect of cilostazol against doxorubicin-induced cardiomyopathy in mice

Koh

Heo

et al. 2015

Free Radical Biology and Medicine

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“…According to the literature, cardiac function and BP were detected (9). At week 5 before sacrifice, the rats in each group were abdominally anesthetized using 10% chloral hydrate (300 mg/kg, i.p.…”

Section: Evaluation Of Cardiac Function and Blood Pressure (Bp)mentioning

confidence: 99%

Copeptin level in the early prediction of cardiorenal syndrome in rats

et al. 2018

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Copeptin (CPP) has been considered as a useful marker for prediction of prognosis in heart diseases. However, CPP has not been investigated sufficiently in cardiorenal syndrome (CRS). The present study aimed to investigate the value of CPP level in predicting CRS in rats with partial nephrectomy combined with myocardial infarction (SNX + MI). A total of 60 male Sprague-Dawley rats were used to establish the CRS model by partial nephrectomy combined with MI. The rats were randomly divided into blank control (CK), SNX, MI and CRS groups. Changes in serum and urine CPP concentrations, hemodynamics, blood pressure, and renal function were examined 1-5 weeks after modeling. The predictive values of CPP in the occurrence of CRS in rats were evaluated using receiver operating characteristic (ROC) curve. The results showed that serum CPP in the CRS group in 1-5 weeks and urine CPP in 3 weeks after modeling increased significantly compared with the CK group. Also, serum B-type natriuretic peptide (BNP) in 1 and 3 weeks and urine BNP in 4-5 weeks after modeling increased significantly. No correlation was found between serum or urine CPP, BNP and BUN levels 1 week after modeling in the CRS group. The ROC curve analysis showed that the area under the curve of CRS predicted by serum CPP at 1 week was 0.908 with 56.59 pg/ml as the cutoff point, and its diagnostic sensitivity and specificity were 87.5 and 80.0%, respectively. To conclude, SNX + MI may be used to establish CRS rat model with cardiac and renal damage. Serum CPP may serve as a specific biomarker for the early prediction of CRS.

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Pathophysiological model of chronic heart failure complicated with renal failure caused by three-quarter nephrectomy and subcutaneous injection of isoprenaline

Cited by 4 publications

References 20 publications

Pharmacological Profile of Loop Diuretic in Experimental Model of Heart Failure

Pharmacological Profile of Loop Diuretic in Experimental Model of Heart Failure

Protective effect of cilostazol against doxorubicin-induced cardiomyopathy in mice

Copeptin level in the early prediction of cardiorenal syndrome in rats

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