Pathophysiological mechanisms of alcoholic myopathy - Lessons from rodent models

Levitt, Danielle E.; Molina, Patricia E.; Simon, Liz

doi:10.51966/jvas.2021.52.2.107-116

Cited by 3 publications

(3 citation statements)

References 47 publications

(57 reference statements)

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“…Chronic alcohol intake leads to glycolytic disorders in rat skeletal muscle [8]. For example, the doi: https://doi.org/10.15407/ubj95.02.058 activity of the glycolytic enzymes aldolase, pyruvate kinase, and lactate dehydrogenase significantly decreased after prolonged ethanol administration [9], which was consistent with the results in humans [10].…”

supporting

confidence: 78%

Biochemical parameters of blood and tissue of the gastrocnemius muscle in chronically alcoholized rats under oral administration of C(60) fullerene aqueous solution

Motuziuk¹,

Nozdrenko²,

Prylutska³

et al. 2023

Ukr.Biochem.J.

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Biochemical indices of blood and tissue of the gastrocnemius muscle chronically alcoholized (for 3, 6 and 9 months) rats were studied. С60 fullerene aqueous solution (C60FAS) was administered orally as a pharmacological agent at a dose of 1 mg/kg daily throughout the experiment in a three routes: 1 h before alcohol intake (preventive regimen), together with alcohol (therapeutic regimen I) and 1 h after alcohol intake (therapeutic regimen II). Creatine phosphokinase (CPK), lactate dehydrogenase (LDH), catalase, superoxide dismutase, glutathione peroxidase (GPx) activity and the level of creatinine, lactate, hydrogen peroxide, reduced glutathione were estimated with clinical diagnostic kits. A pronounced upward trend in creatinine and lactate content, CPK and LDH activity with increasing degree of alcoholic myopathy during experiment was detected. Administration of C60FAS was shown to reduce the biochemical indices of muscle injury and to reduce oxidative processes by maintaining the balance between pro-oxidant and antioxidant systems. The maximum positive effect was observed when C60FAS was administered together with alcohol (therapeutic regimen I). The results indicate on C60 fullerene ability to correct the pathological condition of the muscular system arising from alcohol intoxication. Keywords: alcohol intoxication, antioxidant system, C60 fullerene, creatine phosphokinase, gastrocnemius muscle, lactate dehydrogenase

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supporting

confidence: 78%

Biochemical parameters of blood and tissue of the gastrocnemius muscle in chronically alcoholized rats under oral administration of C(60) fullerene aqueous solution

Motuziuk¹,

Nozdrenko²,

Prylutska³

et al. 2023

Ukr.Biochem.J.

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“…The dose of 100 mM ethanol frequently used in cell culture models is equivalent to a BAC of 0.46 g/dL which is typically supraphysiological [103], although similar or higher values have been reported [104][105][106]. Still, results from various rodent models of ethanol administration (reviewed in [107]) and cell culture-based models provide insight into potential mechanistic impacts of ethanol in human muscle. For a graphic summary of the ethanol-induced changes to mTOR pathway signaling, see Figure 1.…”

Section: Ethanol and Signaling Through Mtormentioning

confidence: 89%

Alcohol, Resistance Exercise, and mTOR Pathway Signaling: An Evidence-Based Narrative Review

2022

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Skeletal muscle mass is determined by the balance between muscle protein synthesis (MPS) and degradation. Several intracellular signaling pathways control this balance, including mammalian/mechanistic target of rapamycin (mTOR) complex 1 (C1). Activation of this pathway in skeletal muscle is controlled, in part, by nutrition (e.g., amino acids and alcohol) and exercise (e.g., resistance exercise (RE)). Acute and chronic alcohol use can result in myopathy, and evidence points to altered mTORC1 signaling as a contributing factor. Moreover, individuals who regularly perform RE or vigorous aerobic exercise are more likely to use alcohol frequently and in larger quantities. Therefore, alcohol may antagonize beneficial exercise-induced increases in mTORC1 pathway signaling. The purpose of this review is to synthesize up-to-date evidence regarding mTORC1 pathway signaling and the independent and combined effects of acute alcohol and RE on activation of the mTORC1 pathway. Overall, acute alcohol impairs and RE activates mTORC1 pathway signaling; however, effects vary by model, sex, feeding, training status, quantity, etc., such that anabolic stimuli may partially rescue the alcohol-mediated pathway inhibition. Likewise, the impact of alcohol on RE-induced mTORC1 pathway signaling appears dependent on several factors including nutrition and sex, although many questions remain unanswered. Accordingly, we identify gaps in the literature that remain to be elucidated to fully understand the independent and combined impacts of alcohol and RE on mTORC1 pathway signaling.

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“…Most current knowledge of the systematic cellular and molecular alterations seen with alcohol-related myopathy is from preclinical rodent studies. 15 However, the pathophysiological mechanisms of alcohol misuse are complex and are influenced by genetics, sex, lifestyle factors, psychosocial determinants, health comorbidities, and patterns of alcohol use. 16 Published literature in the 1990s and early 2000s provided epidemiological evidence for the prevalence of alcohol-related myopathy.…”

mentioning

confidence: 99%

Alcohol and Skeletal Muscle in Health and Disease

Simon

2023

ARCR

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PURPOSE Alcohol-related myopathy is one of the earliest alcohol-associated pathological tissue changes that is progressively exacerbated by cumulative long-term alcohol misuse. Acute and chronic alcohol use leads to changes in skeletal muscle mass and function. As discussed in this evidence-based review, alcohol-mediated mechanisms are multifactorial with effects on anabolic and catabolic signaling, mitochondrial bioenergetics, extracellular matrix remodeling, and epigenomic alterations. However, systematic studies are limited, especially regarding the acute effects of alcohol on skeletal muscle. SEARCH METHODS This review focuses on peer-reviewed manuscripts published between January 2012 and November 2022 using the search terms “alcohol” or “ethanol” and “skeletal muscle” in MEDLINE, PubMed, and Web of Science using EndNote reference management software. SEARCH RESULTS Eligible manuscripts included full-length research papers that discussed acute and chronic effects of alcohol on skeletal muscle mass and function in both clinical and preclinical studies. The review also includes alcohol-mediated skeletal muscle effects in the context of comorbidities. The three databases together yielded 708 manuscripts. Of these, the authors excluded from this review 548 papers that did not have “alcohol” or “muscle” in the title and 64 papers that were duplicates or did not discuss skeletal muscle. Thus, of all the manuscripts considered for this review, 96 are included and 612 are excluded. Additionally, relevant papers published earlier than 2012 are included to provide context to the review. DISCUSSION AND CONCLUSIONS Both acute and chronic alcohol use decrease protein synthesis and increase protein degradation. Alcohol also impairs mitochondrial function and extracellular matrix remodeling. However, there is a gap in the literature on the known alcohol-mediated mechanisms, including senescence, role of immune activation, and interorgan communication, on the development of alcohol-related myopathy. With increased life expectancy, changing alcohol use patterns, and increasing frequency of alcohol use among females, current observational studies are needed on the prevalence of alcohol-related myopathy. Additionally, the compounding effects of acute and chronic alcohol use on skeletal muscle with aging or exercise, in response to injury or disuse, and in the context of comorbidities including diabetes and human immunodeficiency virus (HIV), call for further investigation. Though evidence suggests that abstinence or reducing alcohol use can improve muscle mass and function, they are not restored to normal levels. Hence, understanding the pathophysiological mechanisms can help in the design of therapeutic strategies to improve skeletal muscle health.

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Pathophysiological mechanisms of alcoholic myopathy - Lessons from rodent models

Cited by 3 publications

References 47 publications

Biochemical parameters of blood and tissue of the gastrocnemius muscle in chronically alcoholized rats under oral administration of C(60) fullerene aqueous solution

Biochemical parameters of blood and tissue of the gastrocnemius muscle in chronically alcoholized rats under oral administration of C(60) fullerene aqueous solution

Alcohol, Resistance Exercise, and mTOR Pathway Signaling: An Evidence-Based Narrative Review

Alcohol and Skeletal Muscle in Health and Disease

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