“…In agreement, no central side effect was detected when the toxin was locally injected to mice for studying its action on neuromuscular system and on heat and tactile sensitivity, in vivo. In addition, the analgesic property of CyrTx-1a seems not to be associated with inhibition of hCa V 3.1 and hCa V 3.2, two channels known to be involved in pain process (Choi, Yu, Hwang, & Llinas, 2016;Sekiguchi, Tsubota, & Kawabata, 2018). Moreover, the synthetic peptide has low, at best micromolar, affinities for hNa V 1.5, hCa V 1.2, hK V 7.1, hK V 11.1, and hKir2.1 channels, well-known targets in cardiac safety (Crumb, Vicente, Johannesen, & Strauss, 2016).…”