Pathophysiological Factors which Determine the Exercise Intolerance in Patients with Juvenile Dermatomyositis

Takken, Tim; Elst, E; Net, Janjaap van der

doi:10.2174/1573397052954235

Cited by 11 publications

(17 citation statements)

References 59 publications

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“…Differences in EE and accelerometer counts could be attributed to factors related to disease pathophysiology, sequelae, and drug treatment (42,43). For example, mechanical efficiency due to joint damage or contractures or muscle atrophy from medication and muscle disuse in JA or JDM (23,42); decreased lung function in CF (36) and disturbed muscle metabolism in IMD as well as deconditioning or poor neuromotor control may explain the differences in patterns of movement and increased energy cost of performing physical activities (8,24). …”

Section: Discussionmentioning

confidence: 99%

Validation of Accelerometer Prediction Equations in Children with Chronic Disease

Stephens

Takken

Esliger

et al. 2016

Pediatric Exercise Science

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The purpose of this study was to assess the criterion validity of existing accelerometer-based energy expenditure (EE) prediction equations among children with chronic conditions, and to develop new prediction equations. Children with congenital heart disease (CHD), cystic fibrosis (CF), dermatomyositis (JDM), juvenile arthritis (JA), inherited muscle disease (IMD), and hemophilia (HE) completed 7 tasks while EE was measured using indirect calorimetry with counts determined by accelerometer. Agreement between predicted EE and measured EE was assessed. Disease-specific equations and cut points were developed and cross-validated. In total, 196 subjects participated. One participant dropped out before testing due to time constraints, while 15 CHD, 32 CF, 31 JDM, 31 JA, 30 IMD, 28 HE, and 29 healthy controls completed the study. Agreement between predicted and measured EE varied across disease group and ranged from (ICC) .13–.46. Disease-specific prediction equations exhibited a range of results (ICC .62–.88) (SE 0.45–0.78). In conclusion, poor agreement was demonstrated using current prediction equations in children with chronic conditions. Disease-specific equations and cut points were developed.

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Section: Discussionmentioning

confidence: 99%

Validation of Accelerometer Prediction Equations in Children with Chronic Disease

Stephens

Takken

Esliger

et al. 2016

Pediatric Exercise Science

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“…Furthermore, studies performed in a different population of patients with juvenile‐onset idiopathic inflammatory myopathy have shown lower peak and mean power using a Wingate Anaerobic Exercise Test [11,12]. The authors suggested that the decrease in exercise capacity in persons with juvenile‐onset idiopathic inflammatory myopathy can be explained by lower ATP and PCR concentrations in the studied population.…”

Section: Discussionmentioning

confidence: 99%

Anaerobic Power and Muscle Strength in Human Immunodeficiency Virus–Positive Preadolescents

Ramos¹,

Guttierrez-Teissoonniere²,

Conde³

et al. 2012

PM&R

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Objective To determine the anaerobic power and muscle strength of preadolescents with human immunodeficiency virus (HIV). Design Cross-sectional design. Setting Human performance laboratory at the University District Hospital at the Puerto Rico Medical Center. Participants Fifteen preadolescents (8 girls and 7 boys) with a classification of HIV A and B attending an investigational treatment program at the University Pediatric Hospital. Fifteen seronegative control subjects matched by age and gender also were included. Main Outcome Measures The power of the lower extremities was measured with use of the Wingate Anaerobic Power Test on a MONARK cycle ergometer (mean power in watts). Local muscle strength of the dominant knee extensors (peak torque/body weight × 100) was tested with an isokinetic dynamometer set at 60 deg/s. Statistical analysis was performed with the Wilcoxon signed-rank test, and statistical significance was accepted at an α level of <.05. Results No significant differences between the control group and study group were detected on muscle strength testing. The study group presented a lower anaerobic power (mean power) compared with control subjects (P = .04). Conclusions This exploratory study suggests that HIV-infected preadolescents present lower anaerobic power compared with uninfected control subjects. Our findings of impaired anaerobic capacity can have clinical implications in this population because most of the activities of daily living, such as play, leisure, and sport activities, are short term and high intensity (anaerobic) in nature.

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“…Chronically ill children, including those with CF, may suffer from exercise intolerancethese children have poor fitness, spend less time exercising, and are often deconditioned [14,15]. Many chronic illnesses place a greater energy demand on childrenwalking and other tasks may require more energy expenditure [15][16][17]-which leads to fatigue, lower physical function, and ultimately lower social participation and reduced quality of life. Accordingly, most youth with CF are less active than healthy age-matched peers and activity levels diminish further during adolescence [18].…”

Section: The Role Of Physical Activity In Cfmentioning

confidence: 99%

"CF chatters": the development of a theoretically informed physical activity intervention for youth with cystic fibrosis

Moola

Faulkner²,

Schneiderman³

2011

OJPM

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Despite the benefits of physical activity for youth living with cystic fibrosis (CF), the majority of patients are insufficiently active to meet physical activity recommendations. Existing physical activity interventions are atheoretical and tend to prescribe standardized exercise regimes which are often not appealing for children and compromise long term adherence. Following recent calls for counselling based physical activity approaches in the CF population, this study describes the development of a theoretically informed, parent-mediated, behavioural counselling intervention for CF youth-"CF Chatters". We first a) describe the development of a grounded theory of physical activity in youth with CF; b) explain how this theory informed the development and implementation of the CF Chatters program and c) reflect on the findings of our pilot intervention using a case study research design. CF Chatters participants demonstrated self reported increases in physical activity and quality of life. While further development and more robust objective measures are needed to extend this investigative pilot work, our findings suggest that behavioural counselling is an effective modality for enhancing physical activity participation and quality of life in this life limited group of children and youth.

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Pathophysiological Factors which Determine the Exercise Intolerance in Patients with Juvenile Dermatomyositis

Cited by 11 publications

References 59 publications

Validation of Accelerometer Prediction Equations in Children with Chronic Disease

Validation of Accelerometer Prediction Equations in Children with Chronic Disease

Anaerobic Power and Muscle Strength in Human Immunodeficiency Virus–Positive Preadolescents

"CF chatters": the development of a theoretically informed physical activity intervention for youth with cystic fibrosis

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Pathophysiological Factors which Determine the Exercise Intolerance in Patients with Juvenile Dermatomyositis

Cited by 11 publications

References 59 publications

Validation of Accelerometer Prediction Equations in Children with Chronic Disease

Validation of Accelerometer Prediction Equations in Children with Chronic Disease

Anaerobic Power and Muscle Strength in Human Immunodeficiency Virus–Positive Preadolescents

&quot;CF chatters&quot;: the development of a theoretically informed physical activity intervention for youth with cystic fibrosis

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"CF chatters": the development of a theoretically informed physical activity intervention for youth with cystic fibrosis