Pathophysiological consequences and treatment strategy of obstructive jaundice

Liu, Junjian; Sun, Yimeng; Xu, Yan; Mei, Heng; Guo, Wei; Li, Zhong‐Lian

doi:10.4240/wjgs.v15.i7.1262

Cited by 3 publications

(1 citation statement)

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“…In obstructive jaundice, Bile drainage, surgery, and endoscopic intervention are potential treatment options, depending on the patient's condition. 3 The WHO defines surgery as "an essential component of healthcare worldwide, and often the only treatment option that can alleviate disability and reduce the risk of death from the condition". 4 Postoperative complications are also one of the health problems that cause about 3-12 million deaths yearly.…”

Section: Introductionmentioning

confidence: 99%

Post Operative Management in Intensive Care of Obstructive Jaundice caused by Choledocholithiasis: A Case Report

Kahar,

Wiwi Monika Sari

2023

Ina J Rheum

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Introduction: Gallstones are a very common problem in the global population. 10%-25% of affected people may have specific symptoms, and 1%-2% of them may experience major complications. Case presentation: 83-year-old female patient complained of yellow in her eyes and skin. Patients also felt pain in the right upper abdomen. Laboratory examination revealed increased bilirubin serum. Abdominal Ultrasound examination showed Obstruction of the Bilier Ductus caused by a stone at ductus sisticus and sludge of the gallbladder. The patient was diagnosed with Jaundice obstruction caused by obstruction of the bile ducts due to a stone at the ductus sisticus with a history of nephrectomy, Hypertension, and type 2 diabetes. The patient underwent Laparoscopic cholecystectomy, ERCP, and stent biller, After the procedure, the patient was admitted to the intensive care unit. Conclusion: Understanding the patient's comprehensive medical and surgical history is fundamental in understanding the postoperative patient in the intensive care unit. Adequate resuscitation is necessary for good clinical perfusion and physiological stability of the patient.

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Section: Introductionmentioning

confidence: 99%

Post Operative Management in Intensive Care of Obstructive Jaundice caused by Choledocholithiasis: A Case Report

Kahar,

Wiwi Monika Sari

2023

Ina J Rheum

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The effect of a new magnesium-containing compound on the dynamics of apoptosis and proliferation of hepatocytes in reversible cholestasis in rats in an experiment

Morozov,

Blinova,

Dаvydkin

et al. 2024

jour

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Objective – to study the effect and effectiveness of a derivative of LBK-527on the dynamics of apoptosis and regenerative potential of hepatocytes in reversible cholestasis in rats in an experiment. Material and methods. Reversible occlusion of the choledochus was formed in 130 white non-linear male laboratory rats by fixing the common bile duct to the inner surface of the anterior abdominal wall using a latex tourniquet. After 5 days, the passage of bile was restored, followed by intravenous administration of LBK-527 and a comparison drug (ademethionine) in medium therapeutic doses. The animals were removed from the experiment on 1, 3, 7, 14, 21 days after the restoration of the bile passage, followed by liver extraction for immunohistochemical study of the expression of markers of proliferation and apoptosis of liver cells. Results. It was found that intravenous administration of the substance under study and the comparison drug from the 3rd day leads to a significant decrease in the expression of caspase-3, followed by the restoration of its level to normal values by the end of the experiment. In addition, when studying the expression level of Ki-67, a marked increase in this indicator was observed from the 1st day after the restoration of the bile passage, which indicates the activation of the proliferative potential of hepatocytes. Conclusion. When studying the molecular and cellular mechanisms of action of LBK-527, it was found that it has a pronounced hepatoprotective effect and consists in reducing the severity of apoptosis and intensification of regenerative processes in the liver.

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Lemmel Syndrome: A Surgical Enigma

Ali,

Shetty,

Shetty

2024

Cureus

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A periampullary diverticulum (PAD) is the most common type of duodenal diverticula found in patients undergoing upper gastrointestinal tract assessments. Even while PAD typically does not manifest any symptoms, it can nevertheless be a source of obstructive jaundice in the absence of a tumor or choledocholithiasis, a condition known as Lemmel's syndrome. We report a case of a 60-year-old woman who presented with abdominal discomfort and multiple episodes of vomiting. After comprehensive clinical examination and investigations, a provisional diagnosis of Lemmel's syndrome was made, leading to initial conservative management for diverticulitis, followed by an exploratory procedure. This case underscores the importance of recognizing Lemmel's syndrome as a differential diagnosis for obstructive jaundice when duodenal diverticula are present, to prevent misdiagnosis and ensure timely, appropriate treatment.

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Pathophysiological consequences and treatment strategy of obstructive jaundice

Cited by 3 publications

References 124 publications

Post Operative Management in Intensive Care of Obstructive Jaundice caused by Choledocholithiasis: A Case Report

Post Operative Management in Intensive Care of Obstructive Jaundice caused by Choledocholithiasis: A Case Report

The effect of a new magnesium-containing compound on the dynamics of apoptosis and proliferation of hepatocytes in reversible cholestasis in rats in an experiment

Lemmel Syndrome: A Surgical Enigma

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