Pathophysiological changes associated with sleep disordered breathing and supine sleep position in pregnancy

Robertson, Nicole; Turner, Jessica

doi:10.1016/j.smrv.2019.04.006

Cited by 21 publications

(12 citation statements)

References 96 publications

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“…Causes are most likely to be hormonal and physiological changes of pregnancy, including increased oxygen consumption and metabolic rate, lower overall oxygen reserve, nasopharyngeal oedema, vasomotor rhinitis, and weight gain, which contribute to narrowing of upper airway, reduced functional residual capacity due to diaphragmatic pressure by the growing fetus, and increased arousals during sleep [60,63]. These physiological changes are exacerbated as pregnancy progresses and when combined with obesity, advanced maternal age, and supine sleep position [64][65][66].…”

Section: Plos Onementioning

confidence: 99%

Associations between symptoms of sleep-disordered breathing and maternal sleep patterns with late stillbirth: Findings from an individual participant data meta-analysis

et al. 2020

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Background and objectives Sleep-disordered breathing (SDB) affects up to one third of women during late pregnancy and is associated with adverse pregnancy outcomes, including hypertension, diabetes, impaired fetal growth, and preterm birth. However, it is unclear if SDB is associated with late stillbirth (�28 weeks' gestation). The aim of this study was to investigate the relationship between self-reported symptoms of SDB and late stillbirth. Methods Data were obtained from five case-control studies (cases 851, controls 2257) from New Zealand (2 studies), Australia, the United Kingdom, and an international study. This was a secondary analysis of an individual participant data meta-analysis that investigated maternal going-to-sleep position and late stillbirth, with a one-stage approach stratified by study and site. Inclusion criteria: singleton, non-anomalous pregnancy, �28 weeks' gestation. Sleep data ('any' snoring, habitual snoring �3 nights per week, the Berlin Questionnaire [BQ], sleep quality, sleep duration, restless sleep, daytime sleepiness, and daytime naps) were collected by self-report for the month before stillbirth. Multivariable analysis adjusted for known major risk factors for stillbirth, including maternal age, body mass index (BMI kg/ m2), ethnicity, parity, education, marital status, pre-existing hypertension and diabetes, smoking, recreational drug use, baby birthweight centile, fetal movement, supine going-to-PLOS ONE

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Section: Plos Onementioning

confidence: 99%

Associations between symptoms of sleep-disordered breathing and maternal sleep patterns with late stillbirth: Findings from an individual participant data meta-analysis

et al. 2020

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“…For example, increases in beta-human chorionic gonadotropin (HCG) and progesterone change sleep patterns. While estrogen shortens the duration of rapid eye movement (REM)-sleep, progesterone stimulates sleep by balancing the duration of the REM sleep stage and non-REM (NREM) stage for the health of the mother [8]. Additionally, estrogen influences an increase of secretions, vascularity, and edema in the respiratory tract.…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic Status in Pregnant Women and Sleep Quality During Pregnancy

Silva-Perez¹,

Gonzalez-Cardenas²,

Surani³

et al. 2019

Cureus

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“…It is plausible that maternal oxygen desaturation, although very mild, contributed to the distinctive growth patterns of the offspring observed in our study. Notwithstanding such considerations, thresholds for maternal SpO 2 affecting the fetus have yet to be determined 52 .…”

Section: Discussionmentioning

confidence: 99%

Mild maternal sleep-disordered breathing during pregnancy and offspring growth and adiposity in the first 3 years of life

Brener

Lebenthal

Levy

et al. 2020

Sci Rep

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Sleep-disordered breathing (SDB) during pregnancy has been linked to adverse fetal outcomes. Since the intrauterine milieu plays a critical role in childhood growth, we explored the interactions between maternal SDB and offspring growth and adiposity patterns during infancy. Fifty-eight healthy women with uncomplicated pregnancies underwent an objective sleep study and laboratory evaluation during the third trimester, their offspring underwent a 3-year growth surveillance. The 14 (24.1%) women with SDB had a higher body mass index (BMI) (P = 0.003), elevated C-reactive protein levels (P = 0.003), and decreased HDL-cholesterol levels (P = 0.009) than the women without SDB. A general linear model evaluated the interactions between maternal SDB and offspring growth and adiposity measurements after controlling for gestational age and maternal and paternal BMIs. The offspring of mothers with SDB had a significantly smaller head circumference at birth (P = 0.004), with a distinctive pattern of catchup growth by the end of the first year of life (P = 0.018). Their growth pattern was distinguished by compromised birth weight-to-length, rapid catch-up growth, and an increase in both weight-to-length and triceps thickness by the age of three (P < 0.001 and P = 0.001, respectively). Our findings suggest that maternal SDB during pregnancy affects head circumference growth and adiposity acquisition from birth through infancy.

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Pathophysiological changes associated with sleep disordered breathing and supine sleep position in pregnancy

Abstract: changes associated with sleep disordered breathing and supine sleep position in pregnancy, Sleep Medicine Reviews,

Cited by 21 publications

References 96 publications

Associations between symptoms of sleep-disordered breathing and maternal sleep patterns with late stillbirth: Findings from an individual participant data meta-analysis

Associations between symptoms of sleep-disordered breathing and maternal sleep patterns with late stillbirth: Findings from an individual participant data meta-analysis

Socioeconomic Status in Pregnant Women and Sleep Quality During Pregnancy

Mild maternal sleep-disordered breathing during pregnancy and offspring growth and adiposity in the first 3 years of life

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