Pathophysiological Aspects of Aging in Venous Thromboembolism: An Update

Akrivou, Dimitra; Perlepe, Garyfallia; Kirgou, Paraskevi; Gourgoulianis, Konstantinos; Malli, Foteini

doi:10.3390/medicina58081078

Cited by 12 publications

(10 citation statements)

References 145 publications

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“…In combination with previous studies claiming that testosterone levels in men reach their highest level at approximately 30 years of age and then gradually decrease at a rate of 1% to 2% per year ( Herring et al, 2013 ). Age is an acquired thrombogenic factor that is closely associated with pathological and physiological changes ( Akrivou et al, 2022 ). Biased correlation analysis after controlling for age suggested that as testosterone decreased in men with diabetes, K values decreased and Angle, MA values, and CL values increased.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Sex Hormones, Insulin Dosage, and Risk Factors Associated With Male Diabetic Patients

Chen

2024

Am J Mens Health

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The purpose of this study is to assess the influence of sex hormones and other indicators on risk factors for hypercoagulable states in male patients with type 2 diabetes mellitus. Ninety-two diabetic patients were divided into two groups based on testosterone levels: T1 group (testosterone <12 mmol/L) and T2 group (testosterone >12 mmol/L). Fifty-four non-diabetic patients were used as the control group. Sex hormone index, glucose, insulin, C-peptide, 24-h urinary free cortisol, thromboelastography, and insulin resistance index were measured by radioimmunoassay. Testosterone was lower in the diabetic men than in the control group (12.02 vs 14.77, p < .05), and was inversely related to blood coagulation status, blood glucose level, and cortisol level. Body mass index was positively correlated with estradiol and insulin resistance index. Testosterone was independently associated with the clotting process after controlling for age. Low testosterone is a risk factor for hypercoagulable state in diabetic men. Elevated estradiol and insulin resistance are influential factors for increased body mass index.

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Section: Discussionmentioning

confidence: 99%

Analysis of Sex Hormones, Insulin Dosage, and Risk Factors Associated With Male Diabetic Patients

Chen

2024

Am J Mens Health

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“…A retrospective analysis of a nationwide Swedish registry denoted a skewed distribution for VTE with respect to advancing age [11]. Analysis of the cohorts in the Cardiovascular Health Study and the Atherosclerosis Risk in Communities study revealed an 8% remaining lifetime risk of VTE in adults aged 45-64 years [12] with risk and incidence rates for VTE increasing significantly in subsequent decades [13][14][15][16]. While these distributions clearly demonstrate which age groups bear the major burden of VTE [11,16,17], etiology is not unifactorial.…”

Section: Epidemiology Of Venous Thromboembolismmentioning

confidence: 99%

“…Analysis of the cohorts in the Cardiovascular Health Study and the Atherosclerosis Risk in Communities study revealed an 8% remaining lifetime risk of VTE in adults aged 45-64 years [12] with risk and incidence rates for VTE increasing significantly in subsequent decades [13][14][15][16]. While these distributions clearly demonstrate which age groups bear the major burden of VTE [11,16,17], etiology is not unifactorial. Multiple risk factors are often identified in patients presenting with VTE in the clinic.…”

Section: Epidemiology Of Venous Thromboembolismmentioning

confidence: 99%

Venous thromboembolism: diagnostic advances and unaddressed challenges in management

Mathews,

Hinds,

Nguyen

2024

Current Opinion in Hematology

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Purpose of review This review summarizes recent advances in developing targeted diagnostics for venous thromboembolism (VTE) and unaddressed knowledge gaps in patient management. Without addressing these critical data needs, the morbidity in VTE patients will persist. Recent findings Recent studies investigating plasma protein profiles in VTE patients have identified key diagnostic targets to address the currently unmet need for low-cost, confirmatory, point-of-care VTE diagnostics. These studies and a growing body of evidence from animal model studies have revealed the importance of inflammatory and vascular pathology in driving VTE, which are currently unaddressed targets for VTE therapy. To enhance the translation of preclinical animal studies, clinical quantification of thrombus burden and comparative component analyses between modeled VTE and clinical VTE are necessary. Summary Lead candidates from protein profiling of VTE patients’ plasma offer a promising outlook in developing low cost, confirmatory, point-of-care testing for VTE. Additionally, addressing the critical knowledge gap of quantitatively measuring clinical thrombi will allow for an array of benefits in VTE management and informing the translatability of experimental therapeutics.

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“…CVI is common among geriatric patients due to structural changes that occur in venous valves and walls with age, and CVI has been associated with a three-fold elevated risk of venous thrombosis and pulmonary embolism [ 130 ]. Treating venous thromboembolism in geriatric patients is complex since they have a higher likelihood of thrombosis and bleeding.…”

Section: Reviewmentioning

confidence: 99%

“…Treating venous thromboembolism in geriatric patients is complex since they have a higher likelihood of thrombosis and bleeding. Thus, if there are no contraindications, anticoagulant therapy may be prescribed [ 130 , 131 ].…”

Section: Reviewmentioning

confidence: 99%

Chronic Venous Insufficiency With Emphasis on the Geriatric Population

Mayrovitz¹,

Aoki²,

Colón³

2023

Cureus

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The underpinning of Chronic Venous Insufficiency (CVI) is valvular dysfunction, which manifests on a spectrum depending on the severity of insufficiency and duration of the disease. The mainstay of treatment relies on compression therapy of a proper type and intensity. In older adults, special consideration must be taken during the patient encounter to account for age-related factors. This review discusses the clinical presentation, diagnosis, and mimicking of CVI, focusing mainly on older adults. The epidemiology, risk factors, disease burden, and grave complications -such as thrombosis and ulceration, are reviewed. The physiological impacts of CVI are described, providing the background for treatment strategies, including non-invasive, medical, and surgical therapies. The findings show advanced age to be an important risk factor contributing to CVI and that other age-related factors add to the risk of severe complications. Clinical assessments combined with objective measurements that assess localized skin water using tissue dielectric constant values or whole limb assessments may aid in the differential diagnosis. Furthermore, understanding the mechanism of action of compression therapy, the mainstay of CVI treatment, and its physiological impacts, allows for its informed use in geriatric patients with increased risks of potential compression-related side effects.

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Pathophysiological Aspects of Aging in Venous Thromboembolism: An Update

Cited by 12 publications

References 145 publications

Analysis of Sex Hormones, Insulin Dosage, and Risk Factors Associated With Male Diabetic Patients

Analysis of Sex Hormones, Insulin Dosage, and Risk Factors Associated With Male Diabetic Patients

Venous thromboembolism: diagnostic advances and unaddressed challenges in management

Chronic Venous Insufficiency With Emphasis on the Geriatric Population

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