Pathophysiological and pharmacological modulation of melatonergic system

Priyadarshini, Rekha; Raj, Gerard Marshall; Shewade, Deepak Gopal

doi:10.18203/2319-2003.ijbcp20150363

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…It is well-known that there is a close relationship between the plasma pro les of melatonin and the activity of the pineal gland because the indolamine is not stored there [12,22]. Recently, we reported that removing the pineal gland caused abolished circadian uctuations of melatonin levels in plasma [23],…”

Section: Discussionmentioning

confidence: 86%

“…Aging is associated with a decline in melatonin synthesis and an impaired circadian rhythm of hormonal production, making the organism vulnerable to neurodegenerative diseases, cancer, or metabolic syndrome [10,11]. Clinical data showed that plasma melatonin levels drop more than twice with aging [12]. Pinealectomy, known to disrupt melatonin production as a hormone, accelerates aging [13,14].…”

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confidence: 99%

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The role of melatonin deficiency induced by pinealectomy on motor activity and anxiety responses in young adult, middle-aged and old rats

Tchekalarova,

Krushovlieva,

Ivanova

et al. 2023

Preprint

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Background Aging affects anxiety levels in rats while the pineal gland, via its hormone melatonin, could modulate their inherited life “clock.” The present study aimed to explore the impact of plasma melatonin deficiency on anxiety responses and the possible involvement of the hypothalamic-pituitary-adrenocortical (HPA) axis and heat shock proteins (Hsp) 70 and 90 in the frontal cortex (FC) and the hippocampus in young adult, middle-aged and elderly rats with pinealectomy. Results Melatonin deficiency induced at different life stages did not affect the lifespan of rats. Pinealectomy abolished the circadian rhythm of motor activity, measured for 48 h in the actimeter, in young adult but not in middle-aged rats. Both 18-month-old sham- and rats with pinealectomy exhibited impaired circadian variations of motor activity. The same generations (3- and 18-month-old rats with pinealectomy) had lower anxiety levels than the matched sham groups, measured in three tests: elevated-plus maze, light-dark test, and novelty suppressing feeding test. While the activity of the HPA axis remained intact in young adult and middle-aged rats with melatonin deficiency, high baseline corticosterone level and blunted stress-induced mechanism of its release was detected in the oldest rats. Age-associated reduced Hsp 70 and 90 levels in the FC but not in the hippocampus were detected. Pinealectomy diminished the expression of Hsp 70 in the FC of middle-aged rats compared to the matched sham rats. Conclusions Our results suggest that while melatonin hormonal dysfunction impaired the circadian variations of motor activity and emotional behavior in young adult and elderly rats, the underlying pathogenic mechanism in these generations might be different and needs further verification.

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Section: Discussionmentioning

confidence: 86%

mentioning

confidence: 99%

The role of melatonin deficiency induced by pinealectomy on motor activity and anxiety responses in young adult, middle-aged and old rats

Tchekalarova,

Krushovlieva,

Ivanova

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

The role of melatonin deficiency induced by pinealectomy on motor activity and anxiety responses in young adult, middle-aged and old rats

Tchekalarova,

Krushovlieva,

Ivanova

et al. 2024

Behav Brain Funct

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Background Aging affects anxiety levels in rats while the pineal gland, via its hormone melatonin, could modulate their inherited life “clock.” The present study aimed to explore the impact of plasma melatonin deficiency on anxiety responses and the possible involvement of the hypothalamic-pituitary-adrenocortical (HPA) axis and heat shock proteins (Hsp) 70 and 90 in the frontal cortex (FC) and the hippocampus in young adult, middle-aged and elderly rats with pinealectomy. Results Melatonin deficiency induced at different life stages did not affect the lifespan of rats. Pinealectomy abolished the circadian rhythm of motor activity, measured for 48 h in the actimeter, in young adult but not in middle-aged rats. Pinealectomy reduced the motor activity of the young adult rats during the dark phase and impaired the diurnal activity variations of old rats. The same generations (3- and 18 month-old rats with pinealectomy) had lower anxiety levels than the matched sham groups, measured in three tests: elevated-plus maze, light–dark test, and novelty-suppressed feeding test. While the activity of the HPA axis remained intact in young adult and middle-aged rats with melatonin deficiency, a high baseline corticosterone level and blunted stress-induced mechanism of its release were detected in the oldest rats. Age-associated reduced Hsp 70 and 90 levels in the FC but not in the hippocampus were detected. Pinealectomy diminished the expression of Hsp 70 in the FC of middle-aged rats compared to the matched sham rats. Conclusions Our results suggest that while melatonin hormonal dysfunction impaired the motor activity in the actimeter and emotional behavior in young adult and elderly rats, the underlying pathogenic mechanism in these generations might be different and needs further verification.

show abstract

Pathophysiological and pharmacological modulation of melatonergic system

Cited by 2 publications

References 16 publications

The role of melatonin deficiency induced by pinealectomy on motor activity and anxiety responses in young adult, middle-aged and old rats

The role of melatonin deficiency induced by pinealectomy on motor activity and anxiety responses in young adult, middle-aged and old rats

The role of melatonin deficiency induced by pinealectomy on motor activity and anxiety responses in young adult, middle-aged and old rats

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