Pathophysiological and Genetic Aspects of the Brain–Skin Axis: The Role of Stress and Inflammation in Skin Aging

Abstract

Aging is a genetically programmed process that is influenced by a large number of external and internal factors. The most frequently discussed factor accelerating aging is UV radiation. But among other factors that accelerate aging, we should not forget about chronic stress and chronic inflammation. These factors are interrelated with each other and can mutually enhance the effect of each other. In particular, chronic stress and inflammation can also affect skin aging. So, the skin is an organ of stress factors, as well as sources of some stress factors. Since the topic of the effects of chronic stress and inflammation, and especially its genetic aspects, are quite rare in the literature, the purpose of this review was to combine the available data on the pathogenesis and genetic aspects of stress and inflammation when exposed to skin aging.