Pathophysiological and clinical aspects of comorbidity of coronavirus disease and chronic generalized periodontitis (literature review)

Abstract

The purpose of the literature review was to conduct a general analysis of the literature data on the study of comorbidity between coronavirus disease and inflammatory periodontal diseases. Studies have found that periodontitis is significantly associated with a higher risk of complications from COVID-19, including intensive care unit hospitalization, the need for assisted ventilation and death, as well as increased blood levels of markers associated with worse COVID-19 outcome. 19, such as D-dimer, serum leukocyte level and CRP concentration. The article describes the mechanisms of penetration of the SARS-CoV-2 virus into the human body, the common links of pathogenesis between COVID-19 and periodontitis, the importance of oral hygiene for patients with COVID-19, and considers the clinical and general immunological aspects of inflammation in COVID-19 and periodontitis. Currently, most research is focused on whether the presence of periodontal disease affects the outcome of coronavirus disease. The possibility of cross-talk between SARS-CoV-2 and the oral microbiome, which may affect the subsequent course of periodontitis at the post-covid stage, presents the scientific interest.