Pathomorphological findings in thyroid cancers of children from the Republic of Belarus: a study of 86 cases occurring between 1986 (‘post‐Chernobyl’) and 1991

Furmanchuk, A.W.; Averkin, J.I.; Egloff, B; Ruchti, C; Abelin, Theodor; Schäppi, W.; Korotkevich, E.A.

doi:10.1111/j.1365-2559.1992.tb00423.x

Cited by 101 publications

(46 citation statements)

References 23 publications

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“…The solid variant is most commonly seen in children and has been reported in 430% of patients with papillary carcinoma after the Chernobyl nuclear accident. 64,65 The nuclear features are those of papillary carcinoma, although the nuclei tend to be more rounded than oval.…”

Section: Solid Variantmentioning

confidence: 99%

Papillary thyroid carcinoma: an update

2011

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The past two decades have seen numerous developments in the understanding of the origins and biology of papillary thyroid carcinoma. Advances in molecular biology, clinicopathologic studies of new entities, facility with fine-needle aspiration biopsy, and new radiologic imaging techniques have allowed for earlier diagnosis of these tumors. However, these advances have also caused controversies in cytologic and histopathologic diagnoses as well as therapy decisions. This paper will focus on several pathologic aspects of papillary carcinoma, which impact on its biology and prognosis.

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Section: Solid Variantmentioning

confidence: 99%

Papillary thyroid carcinoma: an update

2011

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“…In Belarus, Northern Ukraine and parts of the Russian Federation, about 2000 cases of thyroid carcinoma can be attributed to exposure to fallout; nearly all are papillary carcinomas, and together they form the largest number of cases of cancer of a single type due to a known cause on a known date that have ever occurred (Williams, 2002). The cases vary in their age at exposure and latency; although over 95% of the cancers are classified as papillary carcinomas, they vary also in their morphology, ranging from a solid immature phenotype, lacking typical architectural differentiation and with limited thyroglobulin content, to welldifferentiated tumours dominated by either papillary or follicular architecture (Furmanchuk et al, 1992;Nikiforov and Gnepp, 1994;Bogdanova et al, 1995;Williams, 1996;Tronko et al, 1999). Many tumours contain a mixture of different patterns.…”

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confidence: 99%

Thyroid carcinoma after Chernobyl latent period, morphology and aggressiveness

et al. 2004

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The large numbers of papillary thyroid carcinomas that have occurred in those exposed to high levels of short-lived isotopes in fallout after Chernobyl provide a unique opportunity to correlate latency and tumour biology. We show that short latency is associated with tumours with a phenotype that is significantly less structurally differentiated, shows significantly less peritumour fibrosis, and significantly more invasive spread when compared to tumours with a longer latent period. In contrast, the type of differentiation (papillary or follicular architecture) is associated with age at exposure. These findings suggest that the initial mutation at the time of exposure played a major role in tumour latency and aggressiveness. We and others have shown that RET-PTC3 rearrangements are associated with the solid morphology seen in these short latency tumours, while classical papillary carcinomas more often show RET-PTC1 rearrangements. Studies in transgenic mice show similar findings, and in vitro studies show that RET-PTC3 induces more rapid growth than RET-PTC1. We therefore suggest that the solid morphology, high frequency of RET-PTC3 rearrangements and aggressive behaviour noted in early investigations of post-Chernobyl tumours were characteristic of short latency rather than the nature of the mutagen, and that successive overlapping waves of papillary carcinoma with differing latency, differing patterns of mutations and differing clinical behaviour are occurring in those exposed to Chernobyl fallout.

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“…Papillary thyroid carcinomas (PTC), including solid and follicular variants, predominate (Furmanchuk et al, 1992;Nikiforov and Gnepp, 1994). In adult thyroid carcinomas, genetic changes have been reported, e.g.…”

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confidence: 99%

Absence of RAS and p53 mutations in thyroid carcinomas of children after Chernobyl in contrast to adult thyroid tumours

Suchy

Waldmann²,

Klugbauer³

et al. 1998

Br J Cancer

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Summary Thyroid carcinomas of an additional series of 34 children exposed to radioactive fall-out after the Chernobyl reactor accident were analysed for mutations in the H-, K-and N-RAS and the p53 gene. Allele-specific oligonucleotide hybridization, single-strand conformation polymorphism (SSCP) and direct sequencing did not disclose mutations in codons 12, 13 and 61 of RAS genes nor mutations in exons 5, 7 and 8 of p53. Considering the recently reported high prevalence of RET rearrangements of the PTC3 type in childhood tumours after Chernobyl (Klugbauer et al, 1995, Oncogene 11: 2459-2467, it follows that RET rearrangements are the most relevant molecular aberration in these radiation-induced tumours. RAS or p53 mutations do not play a role in childhood thyroid carcinogenesis after Chernobyl.

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Pathomorphological findings in thyroid cancers of children from the Republic of Belarus: a study of 86 cases occurring between 1986 (‘post‐Chernobyl’) and 1991

Cited by 101 publications

References 23 publications

Papillary thyroid carcinoma: an update

Papillary thyroid carcinoma: an update

Thyroid carcinoma after Chernobyl latent period, morphology and aggressiveness

Absence of RAS and p53 mutations in thyroid carcinomas of children after Chernobyl in contrast to adult thyroid tumours

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