Pathology of the Pancreas

Klöppel, Günter; Schlüter, E.

doi:10.1007/978-3-642-58380-3_4

Cited by 18 publications

(4 citation statements)

References 156 publications

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“…In recent years, researchers studying the pathogenesis of this disease have turned their attention to the desmoplastic/stromal reaction, a characteristic feature of the majority of pancreatic cancers (5,6). This reaction consists of abundant fibrous tissue composed of extracellular matrix (ECM) proteins, new blood vessels, and stromal cells (7). It is possible that interactions between stromal cells and tumor cells influence the progression of the disease.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

et al. 2008

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Pancreatic stellate cells (PSC) produce the stromal reaction in pancreatic cancer, but their role in cancer progression is not fully elucidated. We examined the influence of PSCs on pancreatic cancer growth using (a) an orthotopic model of pancreatic cancer and (b) cultured human PSCs (hPSC) and human pancreatic cancer cell lines MiaPaCa-2 and Panc-1. Athymic mice received an intrapancreatic injection of saline, hPSCs, MiaPaCa-2 cells, or hPSCs + MiaPaCa-2. After 7 weeks, tumor size, metastases, and tumor histology were assessed. In vitro studies assessed the effect of cancer cell secretions on PSC migration and the effect of hPSC secretions on cancer cell proliferation, apoptosis, and migration. Possible mediators of the effects of hPSC secretions on cancer cell proliferation were examined using neutralizing antibodies. Compared with mice receiving MiaPaCa-2 cells alone, mice injected with hPSCs + MiaPaCa-2 exhibited (a) increased tumor size and regional and distant metastasis, (b) fibrotic bands (desmoplasia) containing activated PSCs within tumors, and (c) increased tumor cell numbers. In vitro studies showed that, in the presence of pancreatic cancer cells, PSC migration was significantly increased. Furthermore, hPSC secretions induced the proliferation and migration, but inhibited the apoptosis, of MiaPaCa-2 and Panc-1 cells. The proliferative effect of hPSC secretions on pancreatic cancer cells was inhibited in the presence of neutralizing antibody to platelet-derived growth factor. Our studies indicate a significant interaction between pancreatic cancer cells and stromal cells (PSCs) and imply that pancreatic cancer cells recruit stromal cells to establish an environment that promotes cancer progression.

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Section: Introductionmentioning

confidence: 99%

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

et al. 2008

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“…The correct identification of the CEUS pattern is compulsory for an immediate prognostic evaluation [76]. In fact, association between intratumoral microvessel density and tumor aggressiveness has already been proved [76,77]: markedly hypovascular lesions, usually owing to the presence of necrotic degeneration, are undifferentiated at pathology and are characterized by a worse prognosis [78]. Moreover, CEUS examination confirms the results obtained at Doppler study regarding the relationship between tumor and adjacent vessels, crucial to define the resectability or unresectability of the pancreatic lesion [79], together with the liver study during the late phase, to exclude the presence of metastases [74].…”

Section: Contrast-enhanced Usmentioning

confidence: 99%

Imaging techniques in pancreatic tumors

D’Onofrio¹,

Gallotti

Mucelli

2010

Expert Review of Medical Devices

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Conventional ultrasonography represents the first diagnostic imaging modality for the study of pancreatic tumors. Contrast-enhanced ultrasound has significantly improved the accuracy of first-line examination and may influence the choice of second-line investigations: multidetector computed tomography is considered the gold standard for studying pancreatic solid lesions and tumor staging, while MRI with magnetic resonance cholangiopancreatography allows better study of pancreatic cystic lesions and the ductal system. To definitely diagnose a pancreatic lesion, image-guided fine-needle-aspiration or biopsy are very often required. PET with 18-fluorodeoxyglucose, endoscopic ultrasound and intraoperative ultrasonography remain techniques often employed in the third line. This article reviews the imaging techniques generally used for diagnosing the main pancreatic tumors, and a work-up algorithm is finally proposed.

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“…This pattern is present in approximately 90% of cases [2,20,26]. Moreover, CEUS enables a better visualization and staging of ductal adenocarcinoma by allowing a better delineation as well as assessment of vascular invasion [23,[27][28][29]. Also CEUS enables liver assessment in the late vascular phases, thus allowing visualization of eventual metastases, with a better accuracy than standard US.…”

Section: Ductal Adenocarcinomamentioning

confidence: 99%

Contrast‐Enhanced Ultrasound for the Assessment of Pancreatic Lesions

Şirli¹,

Popescu²

2017

Challenges in Pancreatic Pathology

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Transabdominal ultrasound (US) is the first-line imaging method used to diagnose pancreatic lesions, but contrast techniques are needed to differentiate among inflammatory and malignant lesions, as well as between pseudocysts and cystic tumors. Contrast-enhanced (CE) ultrasonography has been proven to be a useful tool in this regard with performance similar to contrast-enhanced computer tomography/magnetic resonance imaging (CT/MRI), being also safer and nonirradiant. According to the EFSUMB guidelines on the nonhepatic use of contrast-enhanced ultrasound (CEUS), this method is useful to improve characterization of ductal adenocarcinoma; to differentiate between pseudocysts and cystic tumors; to differentiate vascular (solid) from avascular (liquid/necrotic) components of a lesion; to better define the dimensions and margins of a lesion, including its relationship with adjacent vessels; and to help the choice for a next imaging technique.

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Pathology of the Pancreas

Cited by 18 publications

References 156 publications

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

Imaging techniques in pancreatic tumors

Contrast‐Enhanced Ultrasound for the Assessment of Pancreatic Lesions

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