Pathology of the Lung

Spencer, Herbert R.; Pratt, Philip C.

doi:10.1097/00000658-198007000-00035

Cited by 76 publications

(26 citation statements)

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“…[31][32][33] Pathophysiologically, viral bronchiolitis is an infectious inflammation of the whole respiratory mucosal epithelium, although more pronounced in small bronchioles. 34 This leads to tissue edema and mucus production resulting in thick mucus plaques within the airway lumen and increase in intraluminal DNA concentration due to lysis of inflammatory and sloughed respiratory epithelial cells. 19,34 Taking this into consideration, the exact contribution and importance of each of these possible mechanisms waits to be documented in viral bronchiolitis in animal or in vitro studies.…”

Section: Discussionmentioning

confidence: 99%

“…34 This leads to tissue edema and mucus production resulting in thick mucus plaques within the airway lumen and increase in intraluminal DNA concentration due to lysis of inflammatory and sloughed respiratory epithelial cells. 19,34 Taking this into consideration, the exact contribution and importance of each of these possible mechanisms waits to be documented in viral bronchiolitis in animal or in vitro studies. It is possible that in our study, an improvement in mucociliary transport and a better elimination of intracellular debris may have reduced viral load and decreased ongoing inflammation within the airways.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nebulized 3% Hypertonic Saline Solution Treatment in Hospitalized Infants With Viral Bronchiolitis*

Mandelberg

Tal

Witzling

et al. 2003

Chest

150

207

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nebulized 3% Hypertonic Saline Solution Treatment in Hospitalized Infants With Viral Bronchiolitis*

Mandelberg

Tal

Witzling

et al. 2003

Chest

150

207

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“…The site selectivity of metastases was thought by Ewing (1928) to be determined by haemodynamic considerations of the arterial blood supply, which could be the case in our observations, as the pleura is more invested with the bronchial arterial supply than the parenchyma (Spencer, 1985). However, the soil/seed hypothesis (Murphy et al, 1988), which emphasises the importance of the microenvironment around the metastatic cell, seems attractive since the metastatic mesothelial cells are preferentially localising at a site from which they originated, the pleura, where they ought to have the best microenvironment for continued growth.…”

Section: Discussionmentioning

confidence: 65%

Phenotypic stability and metastatic behaviour of serially xenografted rat mesotheliomas

Edwards

Hill²,

Brown³

et al. 1990

Br J Cancer

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Summary Mesotheliomas induced in rats by intrapleural injection of the fibrous zeolite, erionite, were serially transplanted in nude mice for up to ten generations. The cell phenotypes (epithelial or sarcomatous) were well maintained during passaging, as determined morphologically and by the expression of the cytokeratin markers demonstrated in normal mesothelial cells. Some of the tumours occasionally produced metastasis in nude mice. In contrast, a cloned epithelial cell mesothelioma and sarcomatous cell mesothelioma, the original cells of which were isolated in tissue culture, both produced regular multiple metastases when passaged in nude mice. These metastases were frequently found on the visceral pleura, rather than in the lung parenchyma, in nude mice. The high metastatic rate of the xenograph mesotheliomas derived by in vitro isolation of cells from mesotheliomas is atypical of the usual behaviour of xenografts of mesotheliomas.The fibrous zeolite, erionite, has been shown to be particularly carcinogenic by inhalation both in man (Baris et al., 1979) and animals (Wagner, 1983) and by intrapleural inoculation into rats (Hill et al., 1990).Previously mesotheliomas induced by crocidolite asbestos have been serially transplanted (Wagner et al., 1982) in syngeneic rats with success. However, during passaging it was found that the tumour phenotype changed with passage number, often alternating between epithelial and sarcomatous cell type within a relatively short number of passages. One explanation of this behaviour would be the existence of a stem cell population within the tumour which has the capacity to differentiate into epithelial or sarcomatous cells, possibly due to the various local stimuli (Wagner et al., 1982; Johnson et al., 1984). There is certainly no doubt that the erionite-induced mesotheliomas can have the appearance of producing histological elements, such as bone, which are more fully differentiated forms of tissue than the more simple epithelial or sarcomatous forms (Johnson et al., 1984).One way of resolving whether pluripotential stem cells really do exist in mesotheliomas is to clone the cells derived from them and to grow them in culture before injecting them into a suitable host for tumour production. If cloned mesothelioma cells will produce the same pattern of mixed cell tumours with differentiated tissue elements, such as bone, when passaged in animals, then there can be little doubt as to the existence of a pluripotential stem cell responsible for this. Previous attempts to examine the morphological pattern of the mesotheliomas induced by asbestos using in vitro as well as in vivo techniques have shown that the in vitro cell cultures did not correspond well with the morphology of the original tumours (Gormley et al., 1980). Only one cell line of the uncloned cell lines established produced a tumour resembling a typical mesothelioma in vivo, although tumours were produced from the cell lines established. The selection of malignant elements using soft agar cloning methods (Brown et ...

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“…Evidências que apóiam essa hipótese incluem a alta freqüência de envolvimento do brônquio lobar superior esquerdo, uma área de reconhecida instabilidade no desenvolvimento embrionário tardio. Isto, entretanto, não explica os casos em que não há vestígios de conexão no segmento atré-sico e a presença de anomalias associadas, como os cistos broncogênicos, que se desenvolvem precocemente, quando surgem os brotos brônquicos, sendo proposta uma lesão isquêmica entre a 5ª e a 15ª semanas de vida intra-uterina (11,20,21) . Uma vez que o sítio da atresia pode apresentar vários graus de restos vestigiais, é razoável supor que o insulto vascular possa ocorrer em diferentes momentos, entre a 5ª semana de gestação até o desenvolvimento da árvore brônquica estar completo.…”

Section: Casounclassified

Aspectos radiológicos da atresia brônquica: relato de três casos e revisão da literatura

et al. 2003

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Neu AS et al. Radiol Bras 2003;36(1):47-51 47 INTRODUÇÃOA atresia brônquica congênita é uma malformação incomum do aparelho respiratório caracterizada pela obliteração focal da luz brônquica, mais comumente de um brônquio segmentar (1) . No brônquio atrésico, por não haver comunicação com a árvore central, há acúmulo de secreções, levando ao desenvolvimento da mucocele (2) . Caracteristicamente, há hiperinsuflação segmentar ou lobar adjacente , devido à ventilação pelos canais colaterais.Observa-se, ainda, redução da vascularização no segmento ou lobo envolvido.A maioria dos pacientes é assintomática e os achados ao exame físico são mínimos. As características aos estudos de imagem são altamente sugestivas do diagnóstico. A tomografia computadorizada (TC) é o mé-todo de escolha para o diagnóstico. RELATO DOS CASOS Caso 1Paciente de 45 anos de idade, sexo feminino, casada, branca, procurou o serviço médico por apresentar febre e falta de ar, sem outras queixas. Negava tabagismo ou uso de drogas. Relatou um episódio de pneumonia há 16 anos. Realizou-se radiografia de tórax, que demonstrou volumosa opacidade justa-hilar esquerda, acompanhada de redução da trama vascular pulmonar (Figura 1). Foram solicitados os exames anteriores e uma TC.A TC evidenciou lesão expansiva de aproximadamente 12,0 × 8,0 × 6,0 cm, de Relato de Casos contornos lisos, precisos e lobulados, com densidade máxima de 50 unidades Hounsfield (UH), que não se impregnou pelo meio de contraste intravenoso (Figuras 2 e 3). Havia aprisionamento de ar com hiperinsuflação distal.A análise retrospectiva da radiografia de tórax e da tomografia linear, realizadas em agosto de 1984, permitiu a identificação de brônquios segmentares e subsegmentares distendidos por muco, com aspecto digitiforme, que na ocasião foram considerados como vasos dilatados (Figuras 4 e 5).A paciente foi submetida a segmentectomia ápico-posterior do lobo superior esquerdo. Macroscopicamente, foi identificada cavidade com paredes de 1,0 a 3,0 mm de espessura, parcialmente septada, com alguns pequenos recessos, provavelmente brônquios periféricos obstruídos. A atresia brônquica é uma anomalia congênita rara que usualmente produz massa justa-hilar com hipertransparência distal à radiografia simples. A maioria dos pacientes é jovem e não apresenta sintomas. A tomografia computadorizada confirma o diagnóstico, permitindo o manejo conservador nos casos assintomáti-cos. Os autores relatam três casos de atresia brônquica. Um caso, de particular interesse, estava associado a volumosa broncocele em paciente do sexo feminino, de 45 anos de idade, que apresentou quadro sintomático de infecção respiratória. O diagnóstico foi estabelecido por meio dos achados da radiologia convencional, da tomografia computadorizada e da comparação com radiografias convencionais e tomografia linear prévios, que já demonstravam alterações. Realizou-se uma revisão sobre os achados clínicos e radiológicos dessa malformação. Unitermos: Atresia brônquica; Broncocele; Mucocele brônquica. Caso 2Radiological aspects of ...

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Pathology of the Lung

Cited by 76 publications

References 0 publications

Nebulized 3% Hypertonic Saline Solution Treatment in Hospitalized Infants With Viral Bronchiolitis*

Nebulized 3% Hypertonic Saline Solution Treatment in Hospitalized Infants With Viral Bronchiolitis*

Phenotypic stability and metastatic behaviour of serially xenografted rat mesotheliomas

Aspectos radiológicos da atresia brônquica: relato de três casos e revisão da literatura

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