Pathology of Terrien's Disease

Presence of Circulating Immune Complexes in Patients With Peripheral Corneal Disease

“…Histopathologically, the changes include epithelial and endothelial degeneration, loss of Bowman's membrane, histiocytelike cells and capillaries in a thin, fragmented corneal stroma, and a dis¬ tinct lack of inflammatory cells. 18 Patients with peripheral corneal disease and collagen vascular disor¬ ders were differentiated from the oth¬ er two groups by their systemic symp¬ toms and laboratory findings. Al¬ though these patients complained of pain and had frank corneal ulcers almost invariably associated with adjacent scleritis, the ulcers could be differentiated from Mooren's ulcer by an absence of central undermined edges, lack of central progression, and less circumferential involvement.…”

In Vivo Confocal Microscopy in Terrien Marginal Corneal Degeneration: A Case Report

“…2 Its occurrence is confined primarily to men (3:1) mostly between 20 and 40 years of age. [1][2][3][4][5][6] A variant form with prominent inflammatory signs occurring in a younger population has been observed. 3 In the medical literature, visual acuity, slit-lamp examination, keratometry, cornea topography, histopathology, and ultrasound biomicroscopy have been reported as a criteria to establish the diagnosis of TMD.…”

“…3 In the medical literature, visual acuity, slit-lamp examination, keratometry, cornea topography, histopathology, and ultrasound biomicroscopy have been reported as a criteria to establish the diagnosis of TMD. 1,[4][5][6] In vivo confocal microscopy has been used for observation of the human cornea, at the cellular level, under normal [7][8][9] and pathological conditions, [10][11][12] such as corneal dystrophies. 13 A recent report described corneal microstructural modifications in an early case of TMD by means of laser scanning in vivo corneal confocal microscopy.…”

Visual outcome on Fitting Rose-K2 XL lens in a case with Terrien’s marginal degeneration

“…3 Histologically epithelium may be normal, thickened, and the thinned Bowman's layer and the lamellae may be split or fibrillated. [13][14] The inflammation depends on the form of the disease. Lipid is found consistently.…”