Pathology of silicone leakage from breast implants.

Diest, Paul J. van; Beekman, Werner H.; Hage, J. Joris

doi:10.1136/jcp.51.7.493

Cited by 103 publications

(64 citation statements)

References 26 publications

(25 reference statements)

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“…Silicone granulomas ("siliconomas") usually occur after direct injection of silicone into the breast tissue or after extracapsular rupture of an implant [32]. Foreign body granulomatous response associated with multinucleated giant cells surround silicone.…”

Section: Foreign Body Reactionsmentioning

confidence: 99%

Benign Breast Diseases: Classification, Diagnosis, and Management

2006

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Section: Foreign Body Reactionsmentioning

confidence: 99%

Benign Breast Diseases: Classification, Diagnosis, and Management

2006

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“…It is well documented that silicone gel diffuses from implant devices (referred to as 'silicone bleed') and that SBIs rupture in a timedependent manner [1,10,30,53,54]. In either case, it is not uncommon for the body to be exposed to free silicone gel for extended periods of time.…”

Section: Discussionmentioning

confidence: 97%

Restricted and Shared Patterns of TCR β-chain Gene Expression in Silicone Breast Implant Capsules and Remote Sites of Tissue Inflammation

O’Hanlon

Lawless²,

Katzin

et al. 2000

Journal of Autoimmunity

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“…Conversely, other materials appear to be completely biocompatible. The extent of an adverse reaction depends upon the individual patient and the particular foreign material but can range from mild inflammation to serious tissue fibrosis (3)(4)(5)(6).…”

mentioning

confidence: 99%

Forensic visualization of foreign matter in human tissue by near‐infrared spectral imaging: Methodology and data mining strategies

et al. 2006

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Background:Rapidity of data acquisition, high image fidelity and large field of view are of tremendous value when looking for chemical contaminants or for the proverbial “needle in the haystack” – in this case foreign inclusions in histologic sections of biopsy or autopsy tissues. Near infrared chemical imaging is one of three chemical imaging techniques (NIR, MIR and Raman) based on vibrational spectroscopy, and provides distinct technical advantages for this application.Methods:We have chosen to utilize and evaluate near infrared (NIR) imaging for studies of foreign materials in tissue because the experimental configuration is relatively simple, data collection is rapid, and large sample areas can be screened with high image fidelity and spatial resolution.Results:We have shown that NIR imaging can readily find and identify silicone gel inclusions in biological tissue samples. Additionally, preliminary results indicate that spectral signatures in the data set are also potentially sensitive to structural changes in the surrounding tissue that may be induced by the foreign body.Conclusions:NIR chemical imaging is a powerful, non‐destructive tool for localization and identifying foreign contaminants in biological tissue. Preliminary results indicate that NIR imaging is also sensitive enough to differentiate tissue types (perhaps based on collagen structural differences), and provide data on the spatial localization of these components. © 2006 International Society for Analytical Cytology

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Pathology of silicone leakage from breast implants.

Cited by 103 publications

References 26 publications

Benign Breast Diseases: Classification, Diagnosis, and Management

Benign Breast Diseases: Classification, Diagnosis, and Management

Restricted and Shared Patterns of TCR β-chain Gene Expression in Silicone Breast Implant Capsules and Remote Sites of Tissue Inflammation

Forensic visualization of foreign matter in human tissue by near‐infrared spectral imaging: Methodology and data mining strategies

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