Pathology of Retinoblastoma: An Update

Pathologic evidence of retinoblastoma seeds supported by field emission scanning electron microscopy and Raman spectroscopy

“…Retinoblastoma (RB) is the most common primary intraocular malignancy in children accounting for 3% of all childhood cancers. [ 1 2 3 4 5 6 7 8 9 10 11 12 13 ] RB seedings had been studied clinically and pathologically in the past. [ 4 10 12 13 ] They have a lot of significance in the spreading of RB to the adjoining areas and extraocularly.…”

“…[ 1 2 3 4 5 6 7 8 9 10 11 12 13 ] RB seedings had been studied clinically and pathologically in the past. [ 4 10 12 13 ] They have a lot of significance in the spreading of RB to the adjoining areas and extraocularly. [ 4 10 12 13 ] Vitreous seeds had been classified earlier by Munier[ 12 ] in 2013 as dusts, clouds, spheres, and mixed types.…”

“…[ 4 10 12 13 ] They have a lot of significance in the spreading of RB to the adjoining areas and extraocularly. [ 4 10 12 13 ] Vitreous seeds had been classified earlier by Munier[ 12 ] in 2013 as dusts, clouds, spheres, and mixed types. [ 12 ] Seeds were further grouped as prehyaloids, subhyaloids, epiretinal, intraretinal, and subretinal seeds.…”

“…[ 12 ] Seeds were further grouped as prehyaloids, subhyaloids, epiretinal, intraretinal, and subretinal seeds. [ 12 13 ] Anterior chamber seeds could be depository or infiltrative. [ 12 13 ] We studied the pathological significance of RB seeds with histopathological risk factors.…”

“…[ 12 13 ] Anterior chamber seeds could be depository or infiltrative. [ 12 13 ] We studied the pathological significance of RB seeds with histopathological risk factors. Field emission scanning electron microscopy (FESEM) for seeds, calcifications,[ 14 15 16 ] and Raman spectroscopy [ 17 18 19 20 ] were studied in an index case in the cohort with interesting observations.…”