Pathology of Renal Diseases in the Tropics

Boonpucknavig, Vijitr; Soontornniyomkij, Virawudh

doi:10.1053/snep.2003.50008

Cited by 41 publications

(36 citation statements)

References 99 publications

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“…Fulminant hepatic failure, splenic rupture, acute renal failure or neurological manifestations including intracranial bleeding, seizures and myelitis. [9][10][11][12][13][14] During outbreaks of dengue in India, a good clinical history is still very important so that other common causes of fever like upper respiratory tract infection/urinary tract infection are not overlooked.…”

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confidence: 99%

Clinical profile and outcome of dengue fever in a paediatric tertiary care centre

Moinuddin

Devadas

2017

Int J Contemp Pediatr

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INTRODUCTIONDengue fever is a viral infection caused by one of the four serotype of dengue viruses belongs to flaviviridiae family.1 It has 4 serotypes DENV1, DENV2, DENV3 and DENV4. Dengue virus believed to be originated in Africa about 300year ago.2 Aedes aegypti is the principal vector dengue for fever. DENV is maintained in a humanmosquito-human cycle.3 Incidence of dengue fever and dengue hemorrhagic fever increased thirty folds globally over the last few decades. India first major outbreak was in 1996 at Delhi where more than 10,000 cases and 400 deaths were repored. 4,5 In last decade, dengue has assumed pan India proportions. Outbreak and deaths reported from all over India. In fact, the case fatality rate has been above 1% over the last 10 year. Clinical featuresDengue fever (DF) an acute viral disease manifesting with myalgias, headache, Retro-orbital pain, vomiting maculopapular rash, leucopenia and thrombocytopenia.ABSTRACT Background: A study of different presentation and outcome of dengue fever in tertiary care centre. Methods: The observational cross sectional study was carried out from June to October 2016 in Bowring and Lady Curzon hospital attached to Bangalore Medical College and Research Institute. Included patients from 1 to 18 years of age who presented with febrile illness. WHO classification and definitions were used to classify disease as dengue fever (DF), dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). Clinically, haematological and biochemical findings were recorded till discharge. Results: During study period,142 patients presented with typical features of dengue fever, male being 86 (60%) and female being 56 (40%). Among 142 cases 64 cases were probable dengue, 50 cases were dengue with warning signs and 28 cases were had severe dengue. Fever (100%) was the most common clinical presentation followed by vomiting (70%), body ache (43%), abdominal pain (23%), headache (12%) and rashes (5%). Laboratory findings included thrombocytopenia, leucopenia and elevated liver enzymes. 126 (88%) cases were discharged in clinical stable conditions, (8%) were died during course of treatment and 8 cases left against medical advice. Conclusions: Fever with vomiting and thrombocytopenia were most common presentation of dengue fever, appropriate clinical diagnosis and management is relatively simple, inexpensive and very effective in saving lives as long as long correct and timely interventions instituted.

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Clinical profile and outcome of dengue fever in a paediatric tertiary care centre

Moinuddin

Devadas

2017

Int J Contemp Pediatr

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“…These renal complications can be classified on the basis of their clinical and pathologic characteristics into acute transient reversible glomerulonephritis, chronic progressive irreversible glomerulonephritis, and amyloidosis. [1] In the most severe cases, the acute renal failure (ARF) can be seen. [1] However there are only a few reports concerning its magnitude.…”

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Letter to the Editor: Acute Renal Failure in the Fatal Cases of Dengue Hemorrhagic Fever, a Summary in Thai Death Cases

Wiwanitkit

2005

Renal Failure

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“…The kidneys are consistently recognized among target organs for the virus. Findings include inflammatory changes of and presence of DENV-specific antigen or genome in renal tissues of fatal cases [19][20][21][22][23].…”

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confidence: 99%

Time course of concurrent infection with dengue virus serotypes 2 and 4 detected in urine

et al. 2015

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Background:In hyperendemic areas, concurrent multiserotype dengue virus (DENV) infections commonly occur in both humans and in mosquito vectors. Previous studies have focused on single blood specimens. Objectives: To illustrate and characterize the time course of mixed infection with DENV serotypes 2 (DENV2) and 4 (DENV4) in a single case. Materials and methods: Plasma, saliva, and urine were collected from a patient diagnosed with dengue hemorrhagic fever grade II and secondary DENV infection on days 7, 18, and 31 of his illness. DENV RNA detection was performed using 2 DENV-specific reverse transcriptase-polymerase chain reaction protocols. Cloning and sequencing were performed to quantify the major and minor viral populations in dual-serotype-infected specimen(s). Genotypes of both DENV serotypes were characterized. Results: DENV genome was detected in plasma and saliva only at the first time point (day 7 of illness), but in urine at both the first and second time points (days 7 and 18 of illness). DENV4 serotype was found in all DENV genome-positive specimens. DENV2 serotype was unexpectedly also detected in the first urine specimen. DENV4 as the major and DENV2 as the minor population. The DENV2 serotype was clustered in genotype Asian I and DENV4 serotype in genotype I. Conclusion: To our knowledge, this is the first report of concurrent multiserotype DENV infection detected solely in urine. Prospective noninvasive investigations may determine the prevalence of this phenomenon. Clinical and public health implications of this finding need to be explored.

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Pathology of Renal Diseases in the Tropics

Cited by 41 publications

References 99 publications

Clinical profile and outcome of dengue fever in a paediatric tertiary care centre

Clinical profile and outcome of dengue fever in a paediatric tertiary care centre

Letter to the Editor: Acute Renal Failure in the Fatal Cases of Dengue Hemorrhagic Fever, a Summary in Thai Death Cases

Time course of concurrent infection with dengue virus serotypes 2 and 4 detected in urine

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