Pathology of Pulseless Disease

Nasu, Tsuyoshi

doi:10.1177/000331976301400502

Cited by 198 publications

(16 citation statements)

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“…It has been suggested that narrowing and obstruction of vasa vasorum (particularly adventitial vessels) may play a role in the development of Takayasu's aortitis (47,48). Proliferative changes in veins and arteries that are used as grafts in coronary bypass surgery may also be produced in part by interruption of vasa vasorum (49,50).…”

Section: Takayasu's Aortitis and Occlusion O F Aortocoronary Bypass Gmentioning

confidence: 99%

Role of Vasa Vasorum in Nourishment of the Aorta

Heistad

Marcus²

1979

J Vasc Res

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The media of arteries is virtually avascular. Thus, oxygen and nutrients must reach the cells of the media by diffusion from the lumen of the vessel and from adventitial vessels. The thickness of the thoracic aorta of man and dog exceeds the effective diffusion distance of oxygen, but nutrition is supplemented by vasa vasorum which enter into the outer layers of the media. Occlusion of vasa vasorum in dogs produces medial necrosis, which indicates that these vessels are essential for the nourishment of the aorta. Recently the microsphere method has been used to provide the first measurements of blood flow through vasa vasorum. There is substantial flow to the outer layers of media of the thoracic aorta in dogs, with virtually no blood flow in the inner layers. The vessels are very responsive to physiological stimuli: they dilate during infusion of adenosine and constrict during stimulation of sympathetic nerves. During acute increases in arterial pressure, blood flow to the media decreases probably from distortion of vasa vasorum. Vasa vasorum may play a role in disease states. Insufficient blood flow through vasa vasorum may contribute to medial necrosis of the aorta and to aortic atherosclerosis. A role of vasa vasorum in aortic changes in hypertension and other vascular diseases merits further study.

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Section: Takayasu's Aortitis and Occlusion O F Aortocoronary Bypass Gmentioning

confidence: 99%

Role of Vasa Vasorum in Nourishment of the Aorta

Heistad

Marcus²

1979

J Vasc Res

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“…Im Laufe der letzten Jahren, mit dem Fortschreiten der Angiographie und der Zunahme der Sektionsf/~lle, h/iufen sich die Mitteilungen, die eine Ausdehnung des Prozesses fiber den Bereich des Aortenbogens und der Pulmonalarterie hinaus beschrieben [3,6,10,20]. tIeute fassen manche Autoren in Japan die Takayasu Die Arteriitis ist vor allem durch eine Beteiligung der Vasa vasorum eharakterisiert (Abb.…”

Section: Pathologie Und _~tiologieunclassified

Chirurgische Therapie und Pathologie der Takayasu-Arteriitis

Shionoya

Ban

Nakata

et al. 1973

Langenbecks Arch Chiv

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Surgical Therapy and Pathology of Takayasu-ArteriitisSummary. The pathology of so-called Takayasu's disease is an allergic-hyperergic grannlomatous arteriitis affecting predominantly the aortic arch and its major branches in young women. The arteriitis seems to begin in the adventitia, i.d. in the vasa vasorum, with extension to the media. The restoration of the carotid artery and surgical therapy of hypertension caused by atypical coarctation of the aorta or renovascular lesions are needed, for the occlusive process of the carotid artery causes not infrequently blindness and the patients die mostly of cardiac or cerebrovascular insufficiency due to hypertension.Although the prosthetic bypass graft from the ascending aorta to the internal carotid artery is effective for the carotid-insufficiency, the problems of operative indication remain to be resolved.

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“…(6) The microscopic features of the lesions can be broadly classified into granulomatous inflammation type, diffuse productive inflammation type and fibrosis type [1,2]. The lesions are believed to progress in accordance with this course.…”

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confidence: 99%