Pathology of ochratoxicosis A in young broiler chicks

Dwivedi, P.; Burns, R.B.

doi:10.1016/s0034-5288(18)32009-5

Cited by 106 publications

(36 citation statements)

References 25 publications

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“…In agreement with the results of Dwivedi and Burns (1984) marked alterations were observed in the eggs. Twelve eggs in group #4 presented thinning of wide areas of the shell.…”

Section: Visible Alteration Of Eggssupporting

confidence: 91%

“…4). These lesions appeared more marked when compared with the picture observed in the animals of #1, #2 and control groups and are similar to OA-induced lesions described previously (Dwivedi & Burns, 1984;Kozaczynski, 1994;Lee, Beery, & Chu, 1984). At necropsy the liver surface appeared diffusely yellowish, suggesting fatty infiltration of hepatocytes.…”

Section: Gross and Histological Lesionssupporting

confidence: 87%

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Determination of ochratoxin A in eggs and target tissues of experimentally drugged hens using HPLC–FLD

et al. 2011

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“…In agreement with the results of Dwivedi and Burns (1984) marked alterations were observed in the eggs. Twelve eggs in group #4 presented thinning of wide areas of the shell.…”

Section: Visible Alteration Of Eggssupporting

confidence: 91%

Section: Gross and Histological Lesionssupporting

confidence: 87%

Determination of ochratoxin A in eggs and target tissues of experimentally drugged hens using HPLC–FLD

et al. 2011

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“…Tubulonephrosis has been as- sociated with OA consumption. Tubular dilatation and hypertrophy, swelling of tubular epithelial cells, and desquamation of the tubular basament membrane has been described in young broiler chickens, with the changes usually affecting the proximal convoluted tubules but not being evident in the distal convoluted tubules [19].…”

Section: Resultsmentioning

confidence: 99%

Ochratoxin A in Laying Hens: High-Performance Liquid Chromatography Detection and Cytological and Histological Analysis of Target Tissues

Bozzo

Ceci

Bonerba

et al. 2008

Journal of Applied Poultry Research

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Ochratoxins are fungal secondary metabolites that contaminate grains, legumes, coffee, dried fruits, beer, wine, and meat. Ochratoxins are considered powerful nephrotoxins, carcinogens, teratogens, and immunotoxins in rats and likely in humans. In 2006 during a pilot program of Hazard Analysis Critical Control Point in the Apulian region, Southern Italy, ochratoxin A (OA) was detected in commercial feed for laying hens in 2 farms. The OA-contaminated feed had been administered to animals for at least 2 mo. Analysis by HPLC with fluorometric detection of the tissues of 4 layer hens that displayed gross and microscopical lesions identified OA in the kidney (8.7 to 16.9 g/ kg, average 13.65 ± 3.58 g/kg) and liver (3.7 to 5.1 g/kg, average 4.43 ± 0.64 g/kg) but not in the other tissues.

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“…Ochratoxin A is a mycotoxin produced by certain species of Penicillium and Aspergillus. This toxin has been reported to produce a depletion of lymphocytes in broiler lymphoid organs (Dwivedi and Burns, 1984). In addition, Chang and Hamilton (1980) reported that ingestion of ochratoxin in feed resulted in impaired mobility and function of chicken granulocytes.…”

Section: Environmental Contaminants and Immunosuppressionmentioning

confidence: 99%

Environment-Immune Interactions

1994

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The need for effective immune function for the maintenance of health has been clearly established in both agriculturally significant animal species and humans. Intensive agricultural practices present production species with numerous disease challenges during the rearing period. Environmental factors represent a ubiquitous, yet frequently manageable, category of immunomodulators that can influence immune performance and ultimately disease susceptibility or resistance. However, strategies for assessing overall immune potential have not been widely implemented for agricultural species. This is in contrast to the use of immune evaluation for human health considerations. Immune assessment relative to environmental-immune interactions can produce benefits in two areas. First, the efficiency of the production operation can be enhanced. Second, the welfare of the animals during the production cycle can be optimized. This paper presents an overview of environmental factors known to influence the immune function of poultry and the opportunities to manage environmental factors to benefit the health of the animals. In addition, the paper discusses the status of immunological assessment for humans and laboratory animals and proposes potential immune assessment panels that could serve as a tool to optimize the environmental management of poultry populations.

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Pathology of ochratoxicosis A in young broiler chicks

Cited by 106 publications

References 25 publications

Determination of ochratoxin A in eggs and target tissues of experimentally drugged hens using HPLC–FLD

Determination of ochratoxin A in eggs and target tissues of experimentally drugged hens using HPLC–FLD

Ochratoxin A in Laying Hens: High-Performance Liquid Chromatography Detection and Cytological and Histological Analysis of Target Tissues

Environment-Immune Interactions

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