Pathology of malignant skin tumours

Beesley, Matthew F.; Biswas, Asok

doi:10.1016/j.mpsur.2014.06.007

Cited by 2 publications

(2 citation statements)

References 12 publications

(9 reference statements)

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“…Basal cell carcinoma is a basal cell-derived malignant neoplasm, which usually appears without lesions that are precursors [1]. It is the most common type of malignant tumor occurring on the skin parts that are exposed to sunlight, which its name is derived from its similarity in terms of histological characteristics to the normal epidermal basal cells [3]. It appears as a red nodule with telanglectasia that has slow growth rate but frequent ulceration occurs.…”

Section: Skin Cancer Cellsmentioning

confidence: 99%

“…Skin cancer is currently one of the most common types of cancers, which is found in almost every types of society worldwide [1], particularly in western nations that majority of citizens have light-colored skin, such as United Kingdom [2,3], United States of America [4], and Australia [5]. The incidence of malignant melanoma had been quadrupled between 1982-2012, with the riskiest group is in patients at the age of equal to or above 65 years old [2,3]. Despite representing only 4% of all skin cancer cases, malignant melanoma is the cause of 65% of all deaths related to skin cancer [1].…”

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confidence: 99%

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Effects of Curcumin-Loaded Bacterial Cellulose Films on Cancer Cells

Subtaweesin

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In this study, a curcumin-loaded bacterial cellulose films were developed. Bacterial cellulose films were prepared by culturing Gluconacetobacter xylinus in coconut water-based medium. Curcumin, an active substance found in turmeric (Curcuma longa Linn), was then absorbed into never-dried bacterial cellulose pellicles by immersion in 0.5 and 1.0 mg/ml curcumin solutions, with absolute ethanol as solvent, for 24 hours. The curcumin-loaded bacterial cellulose pellicles were then air-dried. Controlled release of curcumin was achieved in buffer solutions containing Tween 80 and methanol additives, at pH 5.5 and 7.4. Curcumin-loaded bacterial cellulose films prepared with curcumin solutions at concentrations of 0.5 and 1.0 mg/ml demonstrated anticancer activity against A375 human malignant melanoma cells, HT29 human colon cancer cells, and MCF7 human breast cancer cells. On normal cells, specifically human keratinocytes and human dermal fibroblasts, along with Vero kidney epithelial cells, no significant cytotoxic effect was observed. These developed films have properties that would be beneficial in biomedical applications.

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Section: Skin Cancer Cellsmentioning

confidence: 99%