Pathology of Lymphomas, Including Hodgkin’s Disease

Tindle, Barbara H.

doi:10.1007/978-94-009-8279-6_1

Cited by 2 publications

(2 citation statements)

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“…However, in the absence of a well-defined basic architecture as in lymph nodes, to serve as a guideline for the pattern of involvement, the process in other tissues may be difficult to distinguish from neoplastic proliferations, e.g., immunoblastic sarcoma (Tindle 1981). In the tonsil we have found necrosis to be very extensive, as compared with that in lymph nodes, in infectious mononucleosis.…”

Section: Histopathologic Changes In Organs Other Than Lymph Nodesmentioning

confidence: 71%

“…It has become apparent, however, that Reed-Sternberg cells, while diagnostic for Hodgkin's disease, are not pathognomonic for that lesion and may be observed in other diseases (Harrison 1966;Symmers 1968;Lukes, Tindle, and Parker 1969;Hartsock 1968;Strum, Park, and Rappaport 1970;McMahon, Gordon, and Rosen 1970;Agliozzo and Reingold 1971;Tindle, Parker, and Lukes 1972). Infectious mononucleosis as a reactive, and therefore essentially reversible, process has been confused with Hodgkin's disease, as described by the authors cited above, as well as with other lesions in which there is marked cellular pleomorphism, including non-Hodgkin's lymphoma, especially immunoblastic sarcoma (Tindle 1981), and nonlymphoid neoplasms (Strum, Park, and Rappaport 1970). Immunoblastic reactions occur in response to a variety of etiologic agents, and it is not possible to distinguish specific etiologies on the basis of histopathology alone.…”

Section: Pathology Of Infectious Mononucleosismentioning

confidence: 95%

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Infectious Mononucleosis

1989

Clinical Topics in Infectious Disease

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Infectious mononucleosis is a clinical entity characterized by pharyngitis, cervical lymph node enlargement, fatigue and fever, which results most often from a primary Epstein-Barr virus (EBV) infection. EBV, a lymphocrytovirus and a member of the γ-herpesvirus family, infects at least 90% of the population worldwide, the majority of whom have no recognizable illness. The virus is spread by intimate oral contact among adolescents, but how preadolescents acquire the virus is not known. During the incubation period of approximately 6 weeks, viral replication first occurs in the oropharynx followed by viremia as early as 2 weeks before onset of illness. The acute illness is marked by high viral loads in both the oral cavity and blood accompanied by the production of immunoglobulin M antibodies against EBV viral capsid antigen and an extraordinary expansion of CD8 + T lymphocytes directed against EBV-infected B cells. During convalescence, CD8 + T cells return to normal levels and antibodies develop against EBV nuclear antigen-1. A typical clinical picture in an adolescent or young adult with a positive heterophile test is usually sufficient to make the diagnosis of infectious mononucleosis, but heterophile antibodies are not specific and do not develop in some patients especially young children. EBV-specific antibody profiles are the best choice for staging EBV infection. In addition to causing acute illness, long-term consequences are linked to infectious mononucleosis, especially Hodgkin lymphoma and multiple sclerosis. There is no licensed vaccine for prevention and no specific approved treatment. Future research goals are development of an EBV vaccine, understanding the risk factors for severity of the acute illness and likelihood of developing cancer or autoimmune diseases, and discovering anti-EBV drugs to treat infectious mononucleosis and other EBV-spurred diseases.

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Section: Histopathologic Changes In Organs Other Than Lymph Nodesmentioning

confidence: 71%