Pathology of Indolent B-Cell Neoplasms Other than Follicular Lymphoma

Sakata, Seiji; Tsuyama, Naoko; Takeuchi, Kengo

doi:10.3960/jslrt.54.11

Cited by 10 publications

(9 citation statements)

References 71 publications

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“…10 They later described one additional case (case 5). 11 To better understand this entity, we review all 5 cases and summarize the clinical and laboratory information in Table 1. The median age for the 4 cases is 64 years, with a male predominance.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it has been proposed that this rare entity be termed "prolymphocytic/paraimmunoblast lymphoma." 11 Bromodomain and extra-terminal domain (BET) family proteins function as epigenetic readers and facilitate transcription through interaction with acetylated histones and recruitment of transcriptional regulators to specific genomic locations. 12 Bromodomain containing protein 4 (BRD4), 1 of the 4 BET family proteins, plays a dual role in cancer by exerting a tumor-promoting role in hematopoietic malignancies and a tumor-protective role in some solid tumors.…”

Section: Discussionmentioning

confidence: 99%

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Primary Low-Grade B-Cell Lymphoma of Skull With Translocation Between Immunoglobulin and Interferon Regulatory Factor 4 Genes

et al. 2019

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Low-grade B-cell lymphoma with immunoglobulin ( IG) and interferon regulatory factor 4 ( IRF4) gene rearrangement is extremely rare, with only 4 cases being previously reported. In this article, we report one additional case that arises from the skull and review the literature. The patient was a 69-year-old man who presented with recurrent and disabling vertigo and was found to have a 5.0 × 1.7 cm lesion within the left posterior parietal bone. Histological examination revealed a bone lesion with diffuse lymphoid infiltrate comprising of mostly small lymphocytes with scant cytoplasm, slightly irregular nuclei and inconspicuous nucleoli, and scattered larger cells resembling prolymphocytes and paraimmunoblasts. Immunohistochemical studies showed that the neoplastic cells were positive for CD20, CD79a, PAX5, CD23, CD43, BCL-2, BCL-6, MUM-1, LEF-1, and IgM and negative for CD5, CD10, cyclinD1, SOX11, and IgD. Flow cytometric analysis identified CD5 negative and CD10 negative monoclonal B cells with lambda light chain restriction. Fluorescence in situ hybridization analysis revealed del(13q) abnormality, but was negative for IGH/BCL2, IGH/CCND1, and BIRC3/MALT1 translocations. Next-generation sequencing identified IGK-IRF4 rearrangement and BRD4 E1113 del abnormalities. Given a low clinical stage (IE) of the disease, the patient did not receive additional treatments and was free of disease at 1 year after the diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary Low-Grade B-Cell Lymphoma of Skull With Translocation Between Immunoglobulin and Interferon Regulatory Factor 4 Genes

et al. 2019

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“…The authors of the third case considered the composite tumor as transformation of CLL into plasmacytoma. Notably, CLL/SLL with paraimmunoblastic transformation has been reported previously (12), and has been retained as a provisional entity of low-grade B-cell lymphoma (13).…”

Section: Discussionmentioning

confidence: 99%

Composite Nasopharyngeal plasmacytoma with nodal paraimmunoblastic variant of small lymphocytic lymphoma: A case report

et al. 2017

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Abstract.A 78-year-old male who presented with severe shortness of breath and bilateral nasal congestion was shown to exhibit ta mass localized in the nasopharynx. The tumor was diagnosed as an extramedullary plasmacytoma. Peripheral blood eosinophilia had been persistently noted in the preceding 12 years. The plasmacytoma exhibited a predominance of κ-light chain monotypic Mott cells and was admixed with numerous eosinophils. No history of allergic rhinitis, asthma or aspirin sensitivity was elicited. An axillary lymph node was excised two weeks after the nasopharyngeal biopsy, and it exhibited a paraimmunoblastic transformation of small lymphocytic lymphoma. A review of the literature identified few occurrences of such simultaneous tumors in individual patients.

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“…Cases of unclassified low‐grade B cell lymphoma with IRF4 rearrangement are extremely rare, with four such cases having been reported to date exhibiting IRF4‐IGK translocations, and one case showed IRF4‐IGL translocation. In these cases, tumor cells were diffuse, with effaced lymph node architecture and scattered large prolymphocyte‐ or paraimmunoblast‐like cells 11–13 …”

Section: Introductionmentioning

confidence: 99%

B cell lymphoma with IRF4 rearrangement: A clinicopathological study of 13 cases

Zhou

Gu²,

Shen

et al. 2021

Pathology International

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Interferon regulatory factor 4 (IRF4) rearrangement is commonly detected in patients with a range of lymphoproliferative malignancies, including myelomas, large B cell lymphomas and low‐grade B cell neoplasms. However, IRF4 rearrangement is generally a relatively rare finding in these latter two cancer types. In the present article, we describe and summarize the clinicopathological and genetic features of 13 cases of B cell lymphoma with IRF4 rearrangement, including 12 cases of large B cell lymphoma and one case of low‐grade lymphoma exhibiting such rearrangement. These cases were detected in six females and seven males between 14 and 71 years of age. From a morphological perspective, large B cell lymphoma tumors included in this analysis exhibited large neoplastic cells in diffuse or follicular patterns, while the case of low‐grade lymphoma mainly composed of small lymphocytes. All analyzed cases exhibited a split in the IRF4 gene consistent with IRF4 translocation. Three of six analyzed large B cell lymphoma cases harbored IGLL5 mutations. Mutations in SAMHD1 were detected in the low‐grade lymphoma with IRF4 rearrangement case. In summary, our results offer further insight into the morphological and molecular heterogeneity of cases of B cell lymphoma exhibiting IRF4 rearrangements.

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Pathology of Indolent B-Cell Neoplasms Other than Follicular Lymphoma

Cited by 10 publications

References 71 publications

Primary Low-Grade B-Cell Lymphoma of Skull With Translocation Between Immunoglobulin and Interferon Regulatory Factor 4 Genes

Primary Low-Grade B-Cell Lymphoma of Skull With Translocation Between Immunoglobulin and Interferon Regulatory Factor 4 Genes

Composite Nasopharyngeal plasmacytoma with nodal paraimmunoblastic variant of small lymphocytic lymphoma: A case report

B cell lymphoma with IRF4 rearrangement: A clinicopathological study of 13 cases

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