Pathology of eyelid tumors

Pe’er, Jacob

doi:10.4103/0301-4738.181752

Cited by 83 publications

(66 citation statements)

References 50 publications

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“…The primary factors that determine whether ambient radiation will injure the human eye outside of defined laboratory conditions are: (1) the intensity of the light, (2) the wavelength received by ocular tissues and (3) the age of the recipient . In the eye, UVR is not known to contribute to visual perception and there are strong evidences that acute high dose exposure to UVR causes photokeratitis and photoconjunctivitis, while even low dose chronic exposure to UVR is a risk factor for cataract, pterygium and squamous cell carcinoma of the cornea and conjunctiva . There is weaker evidence in relation to other, noncancer eye conditions, related with the oxidative stress (OS) induced by UVR exposure.…”

Section: Introductionmentioning

confidence: 99%

Ultraviolet radiation oxidative stress affects eye health

Ivanov

Mappes

Schaupp

et al. 2018

Journal of Biophotonics

141

132

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In the eye, ultraviolet radiation (UVR) is not known to contribute to visual perception but to mainly damage multiple structures. UVR carries higher energy than visible light and high dose exposure to UVR causes direct cellular damage, which has an important role in the development of cancer. This review provides an overview on the most recent knowledge on the role of UVR in oxidative stress (OS) in relation to noncancer ocular pathologies: various corneal pathologies, cataract, glaucoma and age-related macular degeneration. Possible OS signaling streams and mechanisms in the aging eye are discussed. Excessive exposure to UVR through live may seriously contribute to increase in OS of various eye tissues and thus lead to the advancement of serious ocular pathologies. Children are especially vulnerable to UVR because of their larger pupils and more transparent ocular media: up to 80% of a person's lifetime exposure to UVR is reached before the age of 18. Therefore, efficient everyday protection of the sensitive tissues of the eye by wearing of sunglasses, clear UVR-blocking spectacles or contact lenses should be considered from early age on. Many initiatives are taken worldwide to inform and raise the population's awareness about these possible UVR hazards to the eye.

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Section: Introductionmentioning

confidence: 99%

Ultraviolet radiation oxidative stress affects eye health

Ivanov

Mappes

Schaupp

et al. 2018

Journal of Biophotonics

141

132

View full text Add to dashboard Cite

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“…Eyelid sarcomas are also rare in species other than dog. In man, palpebral angiosarcoma, Kaposi's sarcoma and malignant peripheral nerve sheath tumor have been described (Pe'er, 2016). Palpebral lymphangiosarcomas and hemangiosarcomas have been reported in horses (Serena et al, 2006;Gerding et al, 2015), liposarcoma in guinea pigs (Quinton et al, 2013), hemangiosarcomas and peripheral nerve sheath tumors in cats (Newkirk and Rohrbach, 2009).…”

Section: Discussionmentioning

confidence: 99%

Fibrosarcoma of the eyelid in two sibling Czech wolfdogs

Nordio

Fattori²,

Giudice

2018

Open Vet J.

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Most canine tumors of the eyelid are tumors generally encountered in the skin. They are most commonly of epithelial origin and benign. In this report, we describe the cases of two sibling Czech wolfdogs presented, one year apart, with a subcutaneous mass involving the left eyelid. Both lesions were histologically consistent with a diagnosis of subcutaneous fibrosarcoma. Immunohistochemical analyses of the tumors revealed a mild positivity for vimentin and negativity for GFAP, desmin, αSMA, myoglobin, S100, PNL2 and calponin, excluding all differential diagnosis (i.e. peripheral nerve sheath tumor, melanoma, perivascular sarcoma, myofibroblastic sarcoma, rhabdomyosarcoma). To the best of authors’ knowledge, this is the first report of canine eyelid fibrosarcoma. Since this rare tumor has been observed in two full siblings, we could speculate the existence of some genetic predisposition to sarcoma, however the present data did not allow any definite conclusion on the etiopathogenesis or genetic basis of these tumors.

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“…The cases were further as poorly or well differentiated based on the degree of sebaceous differentiation and cytoplasmic vacuolation. [ 14 ] The presence of pagetoid involvement was also noted. The patients were followed up at 6-month interval after surgery for a mean period of 54 months (range: 11–88 months).…”

Section: Methodsmentioning

confidence: 99%

Immunohistochemical expression of X-linked inhibitor of apoptosis in eyelid sebaceous gland carcinoma predicts a worse prognosis

Jayaraj

Sen

Dhanaraj

et al. 2017

Indian J Ophthalmol

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Purpose:Overexpression of the inhibitors of apoptosis proteins have been demonstrated in a variety and of solid tumors including melanomas and nonmelanomas skin cancers. X-linked inhibitor of apoptosis protein (XIAP) is an inhibitor of apoptosis which prevents apoptosis by inhibiting caspases 9, 7, and 3. The prognostic value of XIAP in sebaceous gland carcinoma (SGC) remains unexplored.Methods:The immunohistochemical expression of XIAP was evaluated in 29 SGC cases.Results:The cytoplasmic overexpression of XIAP was detected in 62% SGC cases. XIAP expression was found to be significantly associated with advanced age, large tumor size, and with reduced disease-free survival (P = 0.0174). XIAP expression and advance tumor Grade III emerged as significant risk factors on univariate analysis. On stepwise multivariate analysis, both increased cytoplasmic XIAP expression and high tumor grade were found to be significantly associated with recurrence. Patients with low XIAP immunoexpression had a longer disease-specific survival than those with high expression in the 5-year follow-up.Conclusion:The present study demonstrates at the immunohistochemical level that XIAP is overexpressed in SGC and that high expression could be of biological significance in the development of eyelid SGC. Our finding suggests that up-regulation of XIAP may aggravate tumor metastasis in SGC.

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Pathology of eyelid tumors

Cited by 83 publications

References 50 publications

Ultraviolet radiation oxidative stress affects eye health

Ultraviolet radiation oxidative stress affects eye health

Fibrosarcoma of the eyelid in two sibling Czech wolfdogs

Immunohistochemical expression of X-linked inhibitor of apoptosis in eyelid sebaceous gland carcinoma predicts a worse prognosis

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