Pathology of Endosulfan

Özmen, Özlem

doi:10.5772/17318

Cited by 5 publications

(2 citation statements)

References 51 publications

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“…The observed increase in infertility in male and female mice was consistent with the epidemiological studies from the affected region ( Jayadevan et al, 2005 ; Kanthila and Shenoy, 2012 ; Satheesh, 2017 ; Badiger et al, 2019 ). It has been shown that ES affects testicular functions due to its effects on reproductive hormones, leading to abnormal spermatozoa and decreased sperm count and sperm motility ( Ozmen, 2011 ; Sebastian and Raghavan, 2015a ; Sengupta and Banerjee, 2013 ). Although there exists a limited amount of human data on the effect of ES, a cohort study by Saiyed et al (2003) among school children (10–19 years old) showed delayed male sexual maturity and interference with male sex-hormone synthesis due to exposure to ES ( Saiyed et al, 2003 ).…”

Section: Discussionmentioning

confidence: 99%

Exposure to endosulfan can cause long term effects on general biology, including the reproductive system of mice

et al. 2022

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Increased infertility in humans is attributed to the increased use of environmental chemicals in the last several decades. Various studies have identified pesticides as one of the causes of reproductive toxicity. In a previous study, infertility was observed in male mice due to testicular atrophy and decreased sperm count when a sublethal dose of endosulfan (3 mg/kg) with a serum concentration of 23 μg/L was used. However, the serum concentration of endosulfan was much higher (up to 500 μg/L) in people living in endosulfan-exposed areas compared to the one used in the investigation. To mimic the situation in an experimental setup, mice were exposed to 5 mg/kg body weight of endosulfan, and reproductive toxicity and long-term impact on the general biology of animals were examined. HPLC analysis revealed a serum concentration of ∼50 μg/L of endosulfan after 24 h endosulfan exposure affected the normal physiology of mice. Histopathological studies suggest a persistent, severe effect on reproductive organs where vacuole degeneration of basal germinal epithelial cells and degradation of the interstitial matrix were observed in testes. Ovaries showed a reduction in the number of mature Graafian follicles. At the same time, mild vacuolation in liver hepatocytes and changes in the architecture of the lungs were observed. Endosulfan exposure induced DNA damage and mutations in germ cells at the molecular level. Interestingly, even after 8 months of endosulfan exposure, we observed increased DNA breaks in reproductive tissues. An increased DNA Ligase III expression was also observed, consistent with reported elevated levels of MMEJ-mediated repair. Further, we observed the generation of tumors in a few of the treated mice with time. Thus, the study not only explores the changes in the general biology of the mice upon exposure to endosulfan but also describes the molecular mechanism of its long-term effects.

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Section: Discussionmentioning

confidence: 99%

Exposure to endosulfan can cause long term effects on general biology, including the reproductive system of mice

et al. 2022

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“…Endosulfan contamination in blood, fat, milk, vegetables, cashew leaves, soil and water has been reported from Padre village of Kasargod district of Kerala, India [2,3]. It causes toxic effect on almost all the organs of both humans and animals including the liver, lung, central nervous system, genital system, pancreas etc [4]. Endosulfan acts as an endocrine disruptor, causing reproductive and developmental damage; and has also been reported to cause immune suppression and cancer in experimental animals [1,[5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Combined toxicity of endosulfan and ochratoxin-A in rats: histopathological changes

Kumar¹,

Bastia²,

Telang³

et al. 2015

J Histol Histopathol

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The aim of this study was to examine and compare the toxic effects of endosulfan and ochratoxin-A (OTA), individually and in combination, in adult male rats with respect to histopathological changes over 30 days of treatment. Adult male Wistar rats were randomly allotted to four groups (individual treatments, combination and control) of 10 rats each and fed OTA @ 4 ppm in feed (Group-I), endosulfan @ 5 mg/kg BW in corn oil by oral gavage (Group-II), and endosulfan with OTA in combination (Group-III) daily for 30 days. Group IV was kept as control and fed toxin free feed. After 30 days of treatment, tissues were collected in 10% buffered formalin for histopathological studies. The hematoxylin and eosin stained paraffin sections showed varying degree of degenerative and necrotic changes in kidneys and liver which were more severe in OTA treated rats in comparison to endosulfan fed group. However, the changes observed in group III rats, which received both OTA and endosulfan were even more pronounced than those observed in rats fed OTA or endosulfan alone. The present findings suggest that OTA and endosulfan had additive effects which may play an important role in pathogenesis.

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Molecular interaction studies of endosulfan with the cholinergic pathway targets – An insilico approach

Dilna

Prasanth

Kanade

2018

Computational Toxicology

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Pathology of Endosulfan

Cited by 5 publications

References 51 publications

Exposure to endosulfan can cause long term effects on general biology, including the reproductive system of mice

Exposure to endosulfan can cause long term effects on general biology, including the reproductive system of mice

Combined toxicity of endosulfan and ochratoxin-A in rats: histopathological changes

Molecular interaction studies of endosulfan with the cholinergic pathway targets – An insilico approach

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