Pathology of congenital Zika syndrome in Brazil: a case series

Martines, Roosecelis B; Bhatnagar, Julu; Ramos, Ana Maria de Oliveira; Davi, Helaine Pompeia Freire; Iglezias, Silvia D’Andretta; Kanamura, Cristina Takami; Keating, M. Kelly; Hale, Gillian; Silva‐Flannery, Luciana; Muehlenbachs, Atis; Ritter, Jana M.; Gary, Joy; Rollin, Dominique; Goldsmith, Cynthia S.; Reagan‐Steiner, Sarah; Ermias, Yokabed; Suzuki, Tadaki; Luz, Kléber Giovanni; Oliveira, Wanderson Kleber de; Lanciotti, Robert S.; Lambert, Amy J.; Shieh, Wun‐Ju; Zaki, Sherif R.

doi:10.1016/s0140-6736(16)30883-2

Cited by 296 publications

(306 citation statements)

References 32 publications

(35 reference statements)

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“…A causal link between ZIKV and these defects was established when the ZIKV genome was identified in the amniotic fluid of women whose fetuses had microcephaly detected during fetal ultrasound (125-127, 132, 133, 135). Researchers also identified ZIKV in placentas from miscarriages and IUGR pregnancies, suggesting that ZIKV also affects placental function and could increase the risk of several pregnancy complications (126,132,136). There is now a global push to understand how ZIKV affects pregnancy and fetal brain development.…”

Section: Zikv and Pregnancymentioning

confidence: 99%

Risks associated with viral infections during pregnancy

Racicot¹,

Mor

2017

Journal of Clinical Investigation

227

204

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Section: Zikv and Pregnancymentioning

confidence: 99%

Risks associated with viral infections during pregnancy

Racicot¹,

Mor

2017

Journal of Clinical Investigation

227

204

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“…Preliminary reports have now estimated as many as 1.3 million cases of infection in this widespread epidemic [2]. Initially it was thought that the ZIKV only causes mild symptoms such as fever, myalgia, and rash; recent studies have revealed that ZIKV can also cause severe neurological pathologies such as neonatal microcephaly and Guillain-Barre syndrome [3]. In response to the spreading epidemic of ZIKV infection, the World Health Organization has declared a Public Health Emergency of International Concern [4].…”

mentioning

confidence: 99%

Mechanisms of activation and inhibition of Zika virus NS2B-NS3 protease

Chen

Yang

et al. 2016

Cell Res

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“…Other studies evidenced the link between ZIKV infection during pregnancy and congenital cerebral malformations in newborns as microcephaly and other dysfunctions (Besnard et al, 2016;Driggers et al, 2016), and this was experimentally supported (Cugola et al, 2016). Moreover, the infection consequences in newborns can cause a range of different pathologies, which were described as the congenital Zika syndrome (Martines et al, 2016). ZIKV may additionally be associated with other neurological complications affecting adults, such as Guillain-Barré Syndrome (Dos Santos et al, 2016).…”

Section: Zika Virus Infectionmentioning

confidence: 84%

Abbreviations and acronyms

2018

Safety Assessment of Transgenic Organisms in the Environment, Volume 8

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This work is published under the responsibility of the Secretary-General of the OECD. The opinions expressed and arguments employed herein do not necessarily reflect the official views of OECD member countries.This document, as well as any data and any map included herein, are without prejudice to the status of or sovereignty over any territory, to the delimitation of international frontiers and boundaries and to the name of any territory, city or area.Please cite this publication as: OECD (2018) The statistical data for Israel are supplied by and under the responsibility of the relevant Israeli authorities. The use of such data by the OECD is without prejudice to the status of the Golan Heights, East Jerusalem and Israeli settlements in the West Bank under the terms of international law.Photo credits: Cover © Maks Ershov.Corrigenda to OECD publications may be found on line at: www.oecd.org/about/publishing/corrigenda.htm. © OECD 2018You can copy, download or print OECD content for your own use, and you can include excerpts from OECD publications, databases and multimedia products in your own documents, presentations, blogs, websites and teaching materials, provided that suitable acknowledgment of the source and copyright owner(s) is given. All requests for public or commercial use and translation rights should be submitted to rights@oecd.org. Requests for permission to photocopy portions of this material for public or commercial use shall be addressed directly to the Copyright Clearance Center (CCC) at info@copyright.com or the Centre francais d'exploitation du droit de copie (CFC) at contact@cfcopies.com. FOREWORD │ 3SAFETY ASSESSMENTOF TRANSGENIC ORGANISMSIN THE ENVIRONMENT, VOLUME 8 © OECD 2018 ForewordModern biotechnologies are applied to plants species (crops, flowers, trees), animals and micro-organisms. The safety of the resulting transgenic organisms when released in the environment for their use in agriculture, forestry, the food and feed industry or for other applications represents a challenging issue. Genetically engineered products are rigorously assessed by their developers during their elaboration, and by governments when ready for release, to ensure high safety standards. This remains essential with new biotechnology developments using insects to fight against disease outbreaks: engineered mosquitoes need to be evaluated through a scientifically sound approach to risk/safety assessment that will inform biosafety regulators and support the decision concerning the release of these novel organisms in the environment.The OECD offers a long-standing recognised expertise in biosafety and contributes to facilitating an harmonised approach. The OECD's Working Group on Harmonisation of Regulatory Oversight in Biotechnology (WG-HROB) was established in 1995. The WG-HROB gathers national authorities responsible for the environmental risk/safety assessment of products of modern biotechnology in OECD countries and other economies. International organisations and experts involved in biosafety activities are a...

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Pathology of congenital Zika syndrome in Brazil: a case series

Abstract: None.

Cited by 296 publications

References 32 publications

Risks associated with viral infections during pregnancy

Risks associated with viral infections during pregnancy

Mechanisms of activation and inhibition of Zika virus NS2B-NS3 protease

Abbreviations and acronyms

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