Pathology of chemically induced chronic active hepatitis in mice

Kitamura, Kazuyuki; Iwasaki, Hitoshi; Yasoshima, Akira; Yoshikawa, Haruhisa; Yoshikawa, Takashi; Okaniwa, Azusa

doi:10.1016/0014-4800(92)90007-x

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…A specific form of necrosis, ''piecemeal necrosis,'' is characterized by necrosis of the limiting plate of the portal tract at the interface of hepatocytes and connective tissue of the portal tract, usually accompanied by inflammation, can be immunemediated, and is seen in mice with resemblance to chronic active hepatitis in man (Kitamura et al 1992;Nonomura et al 1991;Kuriki et al 1983).…”

Section: Differential Diagnosismentioning

confidence: 99%

Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

Thoolen¹,

Maronpot

Harada³

et al. 2010

Toxicol Pathol

509

433

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The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the hepatobiliary system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the hepatobiliary system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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Section: Differential Diagnosismentioning

confidence: 99%

Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

Thoolen¹,

Maronpot

Harada³

et al. 2010

Toxicol Pathol

509

433

View full text Add to dashboard Cite

show abstract

“…Only the negative control group had abnormal ALT values (43.1 ± 2.85 U/L). According to Kitamura [ 60 ] and Huang [ 61 ], typical ALT values are between 5 and 35 U/L in teleosts. All groups treated with LxHs had average values within the healthy range and were statistically different from the negative control group ( p < 0.001; ANOVA with Dunnett’s post hoc test; Figure 12 ), and the lowest values were observed with 1000 and 1500 mg/kg (24.2 ± 5.88, 31.3 ± 2.17 U/L).…”

Section: Resultsmentioning

confidence: 99%

Hypoglycemic Activity of Aqueous Extract of Latex from Hancornia speciosa Gomes: A Study in Zebrafish and In Silico

et al. 2021

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Hancornia speciosa Gomes is a tree native to Brazil and has therapeutic potential for several diseases. Ethnopharmacological surveys have reported that the plant is used as a hypoglycemic agent and to lose weight. This study aimed to evaluate the effects of the aqueous extract from H. speciosa latex (LxHs) in a zebrafish model of diabetes. The extract was evaluated through high-performance thin-layer chromatography (HTPLC), nuclear magnetic resonance (NMR), and Fourier-transform infrared spectroscopy (FT-IR). We then tested treatments with LxHs (500, 1000, and 1500 mg/kg) by assessing blood glucose levels in alloxan-induced diabetic animals, and metformin was used as a control. The toxicity was evaluated through histopathology of the pancreas and biochemical assessment of serum levels of AST, ALT, creatinine, and urea. The extract was also assessed for acute toxicity through several parameters in embryos and adult animals. Finally, we performed in silico analysis through the SEA server and docking using the software GOLD. The phytochemical study showed the compounds cornoside, dihydrocornoide, and 1-O-methyl-myoinositol (bornesitol). The treatment with all doses of LxHs significantly decreased alloxan-induced hyperglycemia without any significant histological or biochemical abnormalities. No significant frequency of teratogenesis was observed in the embryos exposed to the extract, and no significant behavioral changes or deaths were observed in adult animals. In silico, the results showed a potential interaction between inositol and enzymes involved in carbohydrates’ metabolism. Overall, the results show a hypoglycemic activity of the extract in vivo, with no apparent toxicity. The computational studies suggest this could be at least partially due to the presence of bornesitol, since inositols can interact with carbohydrates’ enzymes.

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Toxicologic Pathology

Meador

Cheville²

2009

Ultrastructural Pathology the Comparative Cellular Basis of Disease

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Pathology of chemically induced chronic active hepatitis in mice

Cited by 3 publications

References 22 publications

Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

Hypoglycemic Activity of Aqueous Extract of Latex from Hancornia speciosa Gomes: A Study in Zebrafish and In Silico

Toxicologic Pathology

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