Pathology of benign prostatic hyperplasia

Roehrborn, Claus G.

doi:10.1038/ijir.2008.55

Cited by 312 publications

(266 citation statements)

References 34 publications

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“…Results were expressed as Means ± Standard BPH is a truly hyperplasic process resulting in growth of glandular epithelial and stroma/muscular tissues in prostate, leading to often measurable growth, taking on different shapes and configuration which may impact symptoms such as difficulty in micturation [16].In the present study, PSA level was significantly increased. A raised PSA level can be a sign of prostate cancer (Pca).…”

Section: Resultssupporting

confidence: 58%

Effects of Methanolic Extract of Trichosanthes Cucumerina Seed on Experimentally-Induced Prostatic Hyperplasia

Adefule

Adewole

Arayombo

et al. 2018

ijcrr

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Abstract:Benign prostatic hyperplasia, a non-cancerous condition of unknown cause, is the most common prostate disease in men globally. The present study investigated the possible ameliorative effects of methanolic extract of Trichosanthes cucumerina seeds (METCS) on experimentally-induced prostatic hyperplasia in Wistar rats.Twenty adult, male Wistar rats weighing 150-250 g were randomly divided into four groups of five animals each. Group I, normal control, was given corn oil only; Group II, hormone-treated control (HTC), Groups III and IV, hormone-and extract-treated, received continuous doses of 300 μg and 80 μg of testosterone and estradiol, respectively, on alternate days for three weeks subcutaneously in the inguinal region; while the extract-treated rats received additional 400 mg/kg b.w. (low dose) and 800 mg/kg b.w. (high dose) of METCS orally for another three weeks. Immediately after induction of benign prostatic hypertrophy, some animals were randomly selected and sacrificed for gross inspection of prostate enlargement, prostate specific Page | 20397 antigen analysis (PSA) and sperm count evaluation. These procedures were repeated again after three weeks of extract treatment. The prostates were harvested and processed routinely for paraffin embedding, and stained with hematoxylin and eosin (H&E).Results obtained showed significant (P<0.05) reduction in PSA levels following high doses of METCS and also a reversal of histological hyperplasic changes.

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Section: Resultssupporting

confidence: 58%

Effects of Methanolic Extract of Trichosanthes Cucumerina Seed on Experimentally-Induced Prostatic Hyperplasia

Adefule

Adewole

Arayombo

et al. 2018

ijcrr

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“…In contrast to the pubertal growth phase that involves the entire gland, in about 75% of men, during the fifth decade of life, there is a second growth phase selectively involving one of the three anatomically distinct prostate zones, the periuretral one. Conversely, the peripheral and central zones, which represent up to 95% of the total prostate volume, are usually unaffected (Roehrborn, 2008). BPH can cause LUTS because of compression of the prostatic urethra, which, in the earliest stages, is relatively compensated by the hypertrophy of the bladder smooth muscle.…”

Section: Introductionmentioning

confidence: 99%

Hypovitaminosis D is associated with lower urinary tract symptoms and benign prostate hyperplasia in type 2 diabetes

et al. 2015

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SUMMARYLower urinary tract symptoms (LUTS) may develop more commonly in men with type 2 diabetes mellitus (T2DM). LUTS are often associated with benign prostate hyperplasia (BPH), in general population. An association between LUTS and hypovitaminosis D, and between hypovitaminosis D and type 2 diabetes (T2DM), has also been suggested. Thus, we aim to evaluate possible relationships between hypovitaminosis D, LUTS, and BPH in T2DM men. In this prospective observational study, 67 T2DM males (57.9 AE 9.28 years) underwent medical history collection, International Prostate Symptom Score (IPSS) questionnaire, that allows the identification and grading of LUTS, physical examination, biochemical/hormonal blood tests (fasting plasma glucose, glycated haemoglobin, total cholesterol, high-density lipoprotein cholesterol, triglycerides, creatinine, LH, total testosterone, estradiol (E 2 ), 25-OH-vitamin D, PTH, calcium, phosphate, and PSA) and ultrasound transrectal prostate examination. Subdividing patients into three groups, on the base of 25-OH-vitamin D concentration (sufficiency ≥50; insufficiency >25 < 50; and deficiency ≤25 nM), a significant progressive increase of prostate volume (p = 0.037), IPSS score (p = 0.019), diastolic blood pressure (p = 0.018), and a significant decrease in HDL cholesterol (p = 0.038) were observed. 25-OH-Vitamin D levels were inversely correlated with both IPSS (R = À0.333; p = 0.006) and prostate volume (R = À0.311; p = 0.011). At multivariate analysis, hypovitaminosis D remained an independent predictor of both IPSS and prostate volume. In conclusion, we showed, for the first time, an association between 25-OH-vitamin D deficiency, LUTS, and BPH in T2DM men.

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“…3 Although age remains the best-recognized risk factor for LUTS, LUTS may reflect other systemic derangements. 4 Emerging data indicate nowadays that a spectrum of age-related disorders, such as metabolic syndrome (MetS), type 2 diabetes, cardiovascular disease, hypogonadism or a combination thereof, have a heretofore unrecognized, negative impact on LUTS.…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and lower urinary tract symptoms: the role of inflammation

Gacci

Vignozzi

Sebastianelli

et al. 2012

Prostate Cancer Prostatic Dis

141

137

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BACKGROUND: Epidemiological data indicate that lower urinary tract symptoms (LUTS)/BPH can be associated with metabolic syndrome (MetS). Chronic inflammation has been proposed as a candidate mechanism at the crossroad between these two clinical entities. Aim of study is to examine the correlation among pre-operatory LUTS/BPH severity, MetS features and inflammatory infiltrates in prostatectomy specimens. METHODS: A total of 271 consecutive men treated with simple prostatectomy were retrospectively selected for this study in two tertiary referral centers for LUTS/BPH. Prostate diameters and volume were measured by transrectal ultrasound, LUTS scored by International Prostate Symptom Score (IPSS) and obstruction by uroflowmetry. The International Diabetes Federation and American Heart Association and the National Heart, Lung and Blood Institute was used to define MetS. The inflammatory infiltrate was investigated combining anatomic location, grade and extent of flogosis into the overall inflammatory score (IS); the glandular disruption (GD) was used as a further marker. RESULTS: Eighty-six (31.7%) men were affected by MetS. Prostatic volume and anterior-posterior (AP) diameter were positively associated to the number of MetS components. Among MetS determinants, only dyslipidaemia (increased serum triglycerides and reduced serum high-density lipoprotein) was associated with an increased risk of having a prostatic volume 460 cm 3 (hazard ratio (HR) ¼ 3.268, Po0.001). A significant positive correlation between the presence of MetS and the IS was observed. MetS patients presented lower uroflowmetric parameters as compared with those without MetS (Maximum flow rate (Q max ): 8.6 vs 10.1, P ¼ 0.008 and average flow rate (Q ave ): 4.6 vs 5.3, P ¼ 0.033, respectively), and higher obstructive urinary symptoms score (P ¼ 0.064). A positive correlation among both IS-GD and IPSS Score was also observed (adjusted r ¼ 0.172, P ¼ 0.008 and adjusted r ¼ 0.128, P ¼ 0.050). CONCLUSIONS: MetS is associated with prostate volume, prostatic AP diameter and intraprostatic IS. The significantly positive association between MetS and prostatic AP diameter could support the observation that MetS patients presented lower uroflowmetric parameters. In conclusion, MetS can be regarded as a new determinant of prostate inflammation and BPH progression.

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Pathology of benign prostatic hyperplasia

Cited by 312 publications

References 34 publications

Effects of Methanolic Extract of Trichosanthes Cucumerina Seed on Experimentally-Induced Prostatic Hyperplasia

Effects of Methanolic Extract of Trichosanthes Cucumerina Seed on Experimentally-Induced Prostatic Hyperplasia

Hypovitaminosis D is associated with lower urinary tract symptoms and benign prostate hyperplasia in type 2 diabetes

Metabolic syndrome and lower urinary tract symptoms: the role of inflammation

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