Pathology of a new Toxic Syndrome caused by ingestion of adulterated oil in Spain

Martínez‐Tello, Francisco J.; Navas‐Palacios, José J.; Ricoy, José Ramón; Gil-Martin, Ricardo; Conde-Zurita, Jose M.; Delgado, Flores; Tellez, I.; Cabello, Ana; Madero-García, S

doi:10.1007/bf00496569

Cited by 117 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A careful medical history should identify fi brosis caused by exposure to bleomycin or radiation or by graft-versus-host disease. The eosinophilia-myalgia syndrome and Spanish toxic oil syndrome are historical entities associated with consumption of contaminated L-tryptophan [ 35 ] or rape seed cooking oil [ 36 ], respectively.…”

Section: Diagnosis and Differential Diagnosis Of Gasfmentioning

confidence: 99%

Nephrogenic systemic fibrosis: An epidemic of gadolinium toxicity

Todd

Kay

2008

Curr Rheumatol Rep

View full text Add to dashboard Cite

Nephrogenic systemic fibrosis is a devastating systemic fibrosing disorder that afflicts patients with renal dysfunction. Growing evidence supports the hypothesis that gadolinium-containing contrast agents (GCCAs) trigger the development of nephrogenic systemic fibrosis. Hence, this condition is most appropriately called gadolinium---associated systemic fibrosis (GASF). In this report, we review the history of GASF, its association with prior GCCA exposure, its clinicopathologic features, the relevant pharmacology of GCCAs, the likely role of GCCAs in its pathogenesis, and potential treatments.

show abstract

Section: Diagnosis and Differential Diagnosis Of Gasfmentioning

confidence: 99%

Nephrogenic systemic fibrosis: An epidemic of gadolinium toxicity

Todd

Kay

2008

Curr Rheumatol Rep

View full text Add to dashboard Cite

show abstract

“…We have also observed pancellular toxicity in the lungs of guinea pigs ingesting oleylanilide (42). SOD protects lungs from vascular injury, and the activity of SOD is decreased in the lungs due to anilides ingestion.…”

Section: Sod Gsh-px and Catalase Activities Of Lungmentioning

confidence: 78%

Toxic effects of fatty acid anilides on the oxygen defense systems of guinea pig lungs and erythrocytes

Mukherjee

Ghos

Rodgers

et al. 1994

J. Biochem. Toxicol.

View full text Add to dashboard Cite

Toxic oil syndrome (TOS) is caused by ingestion of denatured edible oils. Even though the etiology and pathogenesis of this disease are not fully known, it is quite clear that generation of free radicals caused by ingestion of fatty acid anilides is responsible for the pathogenetic mechanism in many TOS patients. Fatty acid anilides may also alter the free radical status of lungs and erythrocytes; this possibility may shed some light on understanding toxic oil syndrome. The present study describes the effects of oral administration of fatty acid anilides on the activities of major enzymes involved in the oxygen defense systems of lungs and erythrocytes. Feeding fatty acid anilides caused an increase in the superoxide dismutase (SOD) activity in erythrocytes, whereas it caused a decrease in the SOD activity in lungs. GSH-Px activity was not significantly changed in erythrocytes but was decreased in lungs. Although the activity of catalase was increased only by a higher dose in the erythrocytes, it was not affected in the lung at any dosage. Even though the ingestion of fatty acid anilides caused an increase in the SOD activity in the erythrocytes and a decrease in the SOD activity in the lungs, there was an increase in the lipid peroxidation in both cases. The increase in lipid peroxidation in erythrocytes is probably caused by the accumulation of H2O2, and that in the lungs is due to the accumulation of superoxide anion.

show abstract

“…Microscopic vascular lesions were found consistently in all organs and in all phases of TOS, affecting arterioles, veins and capillaries (28,40). Initially, they consisted of swelling, cytoplasmic vacuolation and necrosis of the endothelial cells.…”

Section: Discussionmentioning

confidence: 96%

Nodular regenerative hyperplasia of the liver associated with the toxic oil syndrome: Report of five cases

Solı́s-Herruzo¹,

Vidal²,

Colina³

et al. 1986

Hepatology

View full text Add to dashboard Cite

Nodular regenerative hyperplasia of the liver developed in five patients who had the toxic oil syndrome caused by ingestion of adulterated cooking oil. This hepatic complication was detected from 19 to 37 months (mean-2.5 years) after the onset of the toxic oil syndrome. Nodular regenerative hyperplasia was asymptomatic, although all patients had persistently abnormal liver function. Hepatomegaly was present in four cases, mild jaundice in three and signs of portal hypertension in two. Pathogenesis of nodular regenerative hyperplasia in toxic oil syndrome is unknown, but probably microcirculatory disturbances within the liver might have played a role. Fibrosis in Zone 3, sinusoidal dilatation and occasionally intralobular hemorrhage were seen in three cases; in one of them, characteristic lesions of veno-occlusive disease were also present. In another case, endarteritis changes of hepatic arterioles were evident.

show abstract

Pathology of a new Toxic Syndrome caused by ingestion of adulterated oil in Spain

Cited by 117 publications

References 29 publications

Nephrogenic systemic fibrosis: An epidemic of gadolinium toxicity

Nephrogenic systemic fibrosis: An epidemic of gadolinium toxicity

Toxic effects of fatty acid anilides on the oxygen defense systems of guinea pig lungs and erythrocytes

Nodular regenerative hyperplasia of the liver associated with the toxic oil syndrome: Report of five cases

Contact Info

Product

Resources

About