Pathology in Practice

Stevens, Brenda J.; Montgomery, Stephanie A.; Phillips, Kathryn; Wester, Maggie W; Jennings, Sydney

doi:10.2460/javma.245.1.57

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…This review does not include the results of the study of Moberg et al which are discussed separately. A total number of 122 cases of mesothelioma, fulfilling the four inclusion criteria set in our study, were found complicated in 47 isolated case reports and 10 case series 1,6,13,17,18,22–73 . Morphological evaluation was made by repeated cytopathological examinations in one case and histopathology in every other cases.…”

Section: Discussionmentioning

confidence: 99%

“…A total number of 122 cases of mesothelioma, fulfilling the four inclusion criteria set in our study, were found complicated in 47 isolated case reports and 10 case series. 1 , 6 , 13 , 17 , 18 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ,…”

Section: Discussionmentioning

confidence: 99%

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Outcome of dogs treated with chemotherapy for mesothelioma: A retrospective clinical study on 40 cases and a literature review

Lajoinie

Chavalle

Floch

et al. 2022

Vet Comparative Oncology

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Mesothelioma is an uncommon cancer in dogs for which there is no established standard of care. Chemotherapy is often suggested despite no definitive proof of efficacy. The aim of this study was to evaluate the impact of chemotherapy on survival of dogs with mesothelioma. A retrospective multicentric study was carried out. To be included, dogs needed to present an evocative clinical evolution and a morphological diagnosis of mesothelioma. Exclusion of other cause of effusion and complete clinical follow‐up were also required. Fourty dogs were included, 27 received chemotherapy (group 1) and 13 did not (group 2). Groups were heterogeneous regarding the proportion of animals undergoing surgery as part of their treatment (16 in group 1, 2 in group 2; p = .016) and homogeneous otherwise. Univariate analysis showed that dogs from group 1 survived significantly longer than dogs from group 2 (MST: 366 vs. 74 days; p < .001). Complete resolution of effusion after the first chemotherapy administration positively correlated with survival in group 1 (MST: 415 vs. 160 days; p < .01). All other variable tested had no significant impact on survival in univariate analysis, but dogs undergoing surgery and dogs having serous membranes' modification at medical imaging tended to survive longer. Multivariate analysis confirmed that chemotherapy was the sole variable independently associated with survival in our study (odds ratio 5.57–6.12; p < .01).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Outcome of dogs treated with chemotherapy for mesothelioma: A retrospective clinical study on 40 cases and a literature review

Lajoinie

Chavalle

Floch

et al. 2022

Vet Comparative Oncology

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Diagnostic dichotomy: A question of thoracic mesothelioma

May

Fews

Tennant³

et al. 2016

Equine Veterinary Education

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Summary A 12‐year‐old Irish Sport Horse gelding was presented with a two‐day history of acute onset dyspnoea, pyrexia, tachycardia and ventral sternal oedema. A pleural effusion was identified, and thoracocentesis yielded a haemorrhagic modified transudate. Cytological examination of the fluid showed numerous red blood cells with smaller numbers of large nucleated cells that exhibited mild anisocytosis and anisokaryosis. Thoracoscopy identified adhesions between the visceral and dorsal parietal pleura, haemorrhagic effusion ventrally and haemorrhagic soft tissue plaques scattered over the diaphragm and mediastinum; biopsies of tissue on the caudal mediastinum were obtained. Histopathological examination of the biopsies identified inflammation, with a suspicion of underlying neoplasia; adenocarcinoma, haemangiosarcoma or mesothelioma were considered most likely, but could not be confirmed on the basis of these examinations. The horse was euthanased, and mesothelioma was diagnosed following post mortem examination. This case demonstrates some of the difficulties associated with the accurate premortem diagnosis of mesothelioma.

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Chemosensitivity of three patient-derived primary cultures of canine pericardial mesothelioma by single-agent and combination treatment

Nabeta,

Kanaya,

Elbadawy

et al. 2023

Front. Vet. Sci.

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IntroductionCanine mesothelioma is a rare malignant tumor that mostly affects body cavities, such as the pericardial and pleural cavities. Chemotherapy plays a crucial role in the treatment of canine mesotheliomas. We aimed to compare the antitumor effects of single-agent and combination chemotherapeutic agents on patient-derived primary cultures of canine pericardial mesothelioma established in this study. We planned to generate xenograft models for future studies.Material and methodsEffusion samples were collected from three dogs with histologically diagnosed pericardial mesothelioma and used for primary culture. Cultured cells were characterized by immunostaining for pan-cytokeratin AE1/AE3, vimentin, Wilms' tumor suppressor gene 1 (WT1), and cytokeratin 5 (CK5). To assess the tumorigenic properties of cells in the effusion and generate a xenograft model, the cell suspension was injected into a severe combined immunodeficient (SCID) mouse either subcutaneously (SC) or intraperitoneally (IP). Lastly, chemosensitivity of established primary cultures against four drugs, doxorubicin, vinorelbine, carboplatin, and gemcitabine, by single-agent treatment as well as combination treatment of carboplatin at a fixed concentration, either 10 or 100 μM, and gemcitabine at different concentrations ranging from 0–1000 μM was assessed by cell viability assay.ResultsPrimary cultures were successfully generated and characterized by dual positivity for AE1/AE3 and vimentin and positive staining for WT-1 and CK5, confirming the mesothelial origin of the cells. In the xenograft models, SC mouse developed a subcutaneous mass, whereas IP mouse developed multiple intraperitoneal nodules. The masses were histopathologically consistent with mesotheliomas. The chemosensitivity assay revealed that carboplatin had the highest anti-tumor effects among the four tested single-agent treatments. Furthermore, carboplatin at 100 μM combined with gemcitabine at clinically relevant doses demonstrated the augmented anti-tumor effects compared to single-agent treatment.Discussion and conclusionPrimary cultures and xenograft models generated in this study could be useful tools for in vitro and in vivo studies of canine mesothelioma. Carboplatin is a highly effective chemotherapeutic agent against canine mesothelioma when used as a sole agent and in combination with gemcitabine.

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Pathology in Practice

Cited by 3 publications

References 13 publications

Outcome of dogs treated with chemotherapy for mesothelioma: A retrospective clinical study on 40 cases and a literature review

Outcome of dogs treated with chemotherapy for mesothelioma: A retrospective clinical study on 40 cases and a literature review

Diagnostic dichotomy: A question of thoracic mesothelioma

Chemosensitivity of three patient-derived primary cultures of canine pericardial mesothelioma by single-agent and combination treatment

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