Pathology and physics of YAG-laser intraocular lens damage

Bath, Patricia E.; Boerner, Carol F.; Dang, Yadavinder

doi:10.1016/s0886-3350(87)80010-x

Cited by 43 publications

(8 citation statements)

References 4 publications

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“…100× original magnification shows that there are more or less round pits as well as pits with cracks of various sizes. This type of laser-induced damage has been described previously [4], [9], [18]. The damage of the pit in figure 3c was deemed moderate, the other examples were scored as mild.…”

Section: Resultsmentioning

confidence: 68%

Optical Scattering Measurements of Laser Induced Damage in the Intraocular Lens

Kruijt

Berg

2012

PLoS ONE

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This study optically determines whether the amount of light scatter due to laser-induced damage to the intraocular lens (IOL) is significant in relation to normal straylight values in the human eye. Two IOLs with laser-induced damage were extracted from two donor eyes. Each IOL had 15 pits and/or cracks. The surface area of each pit was measured using a microscope. For 6 pits per intraocular lens the point spread function (PSF) in terms of straylight was measured and the total straylight for all 15 pits was estimated. The damage in the IOLs was scored as mild/moderate. The total damaged surface areas, for a 3.5 mm pupil, in the two IOLs were 0.13% (0.0127 mm2) and 0.66% (0.064 mm2), respectively. The angular dependence of the straylight caused by the damage was similar to that of the normal PSF. The total average contribution to straylight was log(s) = −0.82 and −0.42, much less than the straylight value of the normal eye.The straylight due to normal levels of laser induced damage of the IOL is much lower than normal straylight values found clinically for the normal eye and may therefore be considered not significant.

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Section: Resultsmentioning

confidence: 68%

Optical Scattering Measurements of Laser Induced Damage in the Intraocular Lens

Kruijt

Berg

2012

PLoS ONE

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“…In fact, its complications include damage to the IOL, intraocular pressure elevation, cystoid macular edema, retinal detachment, IOL subluxation, and localized endophthalmitis exacerbation [28][29][30][31][32][33][34]. It follows that, because of important medical, social and economic implications, there is considerable interest in pharmacological prevention of PCO.…”

Section: Discussionmentioning

confidence: 99%

Bendazac Lysine Inhibition of Human Lens Epithelial Cell Adhesion to Polymethylmethacrylate Intraocular Lenses

Soldo¹,

Milanese²,

Pinza³

et al. 2004

Ophthalmic Res

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The aim of the present work was to evaluate the effect of bendazac lysine on the human lens epithelial cell line HLE-B3 adhesion to polymethylmethacrylate (PMMA) intraocular lenses (IOLs). After adherence to IOLs, cells were incubated in the presence of the drug for 24 h. The number of cells contained in a 6-mm² area was then counted with an inverted phase microscope and adherent cells were distinguished from detached floating cells by focusing through the medium. Results obtained show that bendazac is able to induce a linear dose-dependent inhibition of HLE-B3 adhesiveness to PMMA IOLs. In particular, treatment with bendazac 33, 100 and 300 µM resulted in a 15, 32 and 54% inhibition, respectively. Statistical analysis shows that this effect is significant at 100 µM (p < 0.05) and 300 µM (p < 0.01). The analysis of the effects of bendazac on the viability and on the proliferative capacity of HLE-B3 cells did not show any drug-related toxicity up to the concentration of 400 µM. The present study demonstrates that bendazac lysine is able to inhibit adhesion of lens epithelial cells to PMMA IOLs and suggests the potential beneficial use of this drug in preventing secondary cataract development.

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“…Nach Kapsulotomie mittels Nd:YAG-Laser kann es neben einer erhöhten Wahrscheinlichkeit, an einer Amotio retinae, an einem zystoiden Makulaödem oder einem Glaukom zu erkranken auch zu Defekten der IOL kommen [3]. Diese IOL-Beschädigung ist eine unerwünschte Komplikation, die bei stärkerer Ausprägung zu Blendung, Lichtstreuung, Visusabfall und Doppelbildwahrnehmung führen kann.…”

Section: Materialveränderungen Bei Der Neodymium:yag-kapsulotomieunclassified

Aktueller Vergleich von Intraokularlinsen - eine Übersicht

Dick¹,

Augustin²

2001

Klin Monatsbl Augenheilkd

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The wide array of intraocular lenses (IOLs) commercially available today makes it a formidable challenge to choose the most appropriate lens for the patient. Many wonder whether there truly are clinical differences among various IOLs. This update traces the evolution of IOLs in response to the widespread acceptance of phacoemulsification, and discusses the respective advantages and disadvantages of the IOLs available today based on clinical investigations.

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Pathology and physics of YAG-laser intraocular lens damage

Cited by 43 publications

References 4 publications

Optical Scattering Measurements of Laser Induced Damage in the Intraocular Lens

Optical Scattering Measurements of Laser Induced Damage in the Intraocular Lens

Bendazac Lysine Inhibition of Human Lens Epithelial Cell Adhesion to Polymethylmethacrylate Intraocular Lenses

Aktueller Vergleich von Intraokularlinsen - eine Übersicht

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