Pathology and bio markers of prostate cancer

Sakr, W. A.; Mk, Brawer; Jw, Mason; Donohue, Robert E.; Schulman, C

doi:10.1038/sj.pcan.4500277

Cited by 6 publications

(4 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histologically, the atypia observed in HGPIN is virtually indistinguishable from that of prostate cancer except that in HGPIN the basal membrane is still intact (Sakr et al, 1999). As HGPIN progresses, the likelihood of basal cell layer disruption increases.…”

Section: Similarities Between Pin and Prostate Cancermentioning

confidence: 79%

See 1 more Smart Citation

Prostate Cancer Precursor Diseases

Papatsoris¹,

Kostopoulos²,

Migdalis³

et al. 2012

Intraepithelial Neoplasia

View full text Add to dashboard Cite

Section: Similarities Between Pin and Prostate Cancermentioning

confidence: 79%

“…Allelic loss is common in PIN and prostate cancer (Sakr et al, 1999). The frequent 8p12-21 allelic loss commonly found in prostate cancer is also found in microdissected PIN.…”

Section: Similarities Between Pin and Prostate Cancermentioning

confidence: 97%

Prostate Cancer Precursor Diseases

Papatsoris¹,

Kostopoulos²,

Migdalis³

et al. 2012

Intraepithelial Neoplasia

View full text Add to dashboard Cite

“…Several genetic changes encountered in prostate cancer cells can be found in PIN lesions . Allelic loss is common in PIN and prostate cancer (Sakr et al, 1999 (Baltaci et al, 2000). As in prostate cancer, there is also evidence of aneuploidy and an increase in microinvascular density, both frequently regarded as evidence of aggressiveness in PIN (Montironi et al, 1993).…”

Section: Similarities Between Pin and Prostate Cancermentioning

confidence: 99%

Intraepithelial Neoplasia

2009

View full text Add to dashboard Cite

She attended medical school in India (Meerut, UP) and graduated in 2001. She then specialized in Pathology at King Georges' Medical University, Lucknow (UP), receiving her postgraduate medical degree (MD) in 2007. As a medical student she received various recognitions in academic circles. For more than three years, she has been actively engaged in research at the National University of Singapore. Her areas of research include identifying biomarkers in patients at high risk of gastric cancer, prognostic biomarkers in hepatocellular carcinoma and cervical carcinoma and identifying the origin of Barrett's Oesophagus. She is also involved in research projects involving confocal laser endomicroscopy of the gastrointestinal tract and Laser Capture Microdissection, and has been an author and co-author in various papers on topics within her research interest. ContentsPreface XIII Part Intraepithelial Neoplasia of Oral Cavity 1

show abstract

“…Additionally, with prostate tumors usually showing multifocal growth behavior [14], a significant number of cancer foci remains undetected during prostate biopsies, and tumor aggressiveness is often underestimated [14,15].…”

Section: Introductionmentioning

confidence: 99%

Ex Vivo High-Resolution Magic Angle Spinning (HRMAS) 1H NMR Spectroscopy for Early Prostate Cancer Detection

Steiner

Schmidt

Fellmann

et al. 2022

Cancers

View full text Add to dashboard Cite

The aim of our study was to assess ex vivo HRMAS (high-resolution magic angle spinning) 1H NMR spectroscopy as a diagnostic tool for early PCa detection by testing whether metabolomic alterations in prostate biopsy samples can predict future PCa diagnosis. In a primary prospective study (04/2006–10/2018), fresh biopsy samples of 351 prostate biopsy patients were NMR spectroscopically analyzed (Bruker 14.1 Tesla, Billerica, MA, USA) and histopathologically evaluated. Three groups of 16 patients were compared: group 1 and 2 represented patients whose NMR scanned biopsy was histobenign, but patients in group 1 were diagnosed with cancer before the end of the study period, whereas patients in group 2 remained histobenign. Group 3 included cancer patients. Single-metabolite concentrations and metabolomic profiles were not only able to separate histobenign and malignant prostate tissue but also to differentiate between samples of histobenign patients who received a PCa diagnosis in the following years and those who remained histobenign. Our results support the hypothesis that metabolomic alterations significantly precede histologically visible changes, making metabolomic information highly beneficial for early PCa detection. Thanks to its predictive power, metabolomic information can be very valuable for the individualization of PCa active surveillance strategies.

show abstract

Pathology and bio markers of prostate cancer

Cited by 6 publications

References 51 publications

Prostate Cancer Precursor Diseases

Prostate Cancer Precursor Diseases

Intraepithelial Neoplasia

Ex Vivo High-Resolution Magic Angle Spinning (HRMAS) 1H NMR Spectroscopy for Early Prostate Cancer Detection

Contact Info

Product

Resources

About