Abstract:Background: High grade prostatic intraepithelial neoplasia (HGPIN) is the only established precursor for prostate cancer (PCa), with high predictive value as a marker for PCa. About 2% of contemporary needle biopsies contain collections of small acini suspicious for PCa but which fall below the diagnostic threshold. These cases are reported as atypical small acinar proliferation suspicious for but not diagnostic of malignancy (ASAP). Identification of HGPIN, ASAP, or both, warrant repeat biopsy for concurrent … Show more
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