Pathologies in functional connectivity, feedback control and robustness: a global workspace perspective on autism spectrum disorders

Glazebrook, James F.; Wallace, Rodrick

doi:10.1007/s10339-014-0636-y

Cited by 12 publications

(9 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A later fMRI study of the EFT found not only reduced activation of the same visuospatial network, but also reduced connectivity between frontal areas and visuospatial areas (Damarla et al, 2010). A consistent finding in neuroimaging work in ASD research is indeed changes in connectivity, with many studies showing reduced long range connectivity in individuals with ASD (Glazebrook and Wallace, 2015; Kikuchi et al, 2015). This further supports the role of connectivity in atypical perceptual processing in ASD.…”

Section: Theories Of Altered Sensory and Cognitive Functioning In Asdsupporting

confidence: 52%

Behavioral, perceptual, and neural alterations in sensory and multisensory function in autism spectrum disorder

Baum

Stevenson

Wallace

2015

Progress in Neurobiology

299

267

View full text Add to dashboard Cite

Although sensory processing challenges have been noted since the first clinical descriptions of autism, it has taken until the release of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) in 2013 for sensory problems to be included as part of the core symptoms of autism spectrum disorder (ASD) in the diagnostic profile. Because sensory information forms the building blocks for higher-order social and cognitive functions, we argue that sensory processing is not only an additional piece of the puzzle, but rather a critical cornerstone for characterizing and understanding ASD. In this review we discuss what is currently known about sensory processing in ASD, how sensory function fits within contemporary models of ASD, and what is understood about the differences in the underlying neural processing of sensory and social communication observed between individuals with and without ASD. In addition to highlighting the sensory features associated with ASD, we also emphasize the importance of multisensory processing in building perceptual and cognitive representations, and how deficits in multisensory integration may also be a core characteristic of ASD.

show abstract

Section: Theories Of Altered Sensory and Cognitive Functioning In Asdsupporting

confidence: 52%

Behavioral, perceptual, and neural alterations in sensory and multisensory function in autism spectrum disorder

Baum

Stevenson

Wallace

2015

Progress in Neurobiology

299

267

View full text Add to dashboard Cite

show abstract

“…Specifically, high clustering coefficients suggest overconnectivity, which may not be functional. Instead, this pattern of overconnectivity may result in diffuse processing and recruitment of nonspecialized neural mechanisms (Glazebrook & Wallace, 2015). The increased energetic cost required to transmit signals across a diffuse processing system may in turn decrease efficiency of processing (Bullmore & Sporns, 2009).…”

Section: Resultsmentioning

confidence: 99%

Behavioral comparisons in Autism Spectrum Disorder and Developmental Coordination Disorder: A systematic literature review

Caçola

Miller

Williamson

2017

Research in Autism Spectrum Disorders

View full text Add to dashboard Cite

Background Autism Spectrum Disorder (ASD) and Developmental Coordination Disorder (DCD) are developmental disorders that, since the DSM-5, can be diagnosed as co-occurring conditions. While some recent studies suggest that ASD and DCD have similar traits, others show clear behavioral distinctions between the two conditions. By gathering all studies that included (1) an ASD group and a DCD group, (2) an ASD+DCD group and a DCD group, or (3) ASD, ASD+DCD, and DCD groups, we aimed to identify similarities and differences in behaviors between the two disorders. Method We used a systematic search of PubMed (1946 –), Scopus (1970 –), PsycINFO (via EBSCO, 1600 –), CINAHL (via EBSCO, 1937 –), SportDiscus (via EBSCO, 1985 –), and WorldCat (via FirstSearch) in addition to reference list and author name searching PubMed, Scopus, PsycINFO, CINAHL, SportDiscus, and WorldCat to identify original studies that met the following criteria: (1) an ASD group and a DCD group, (2) an ASD+DCD group and a DCD group, or (3) ASD, ASD+DCD, and DCD groups. Results From the 1,598 articles screened, 11 were included in the qualitative analysis. The articles included reported more differences than similarities in individuals with ASD and DCD, with clear distinctions for working memory ability, gestural performance, grip selection, and cortical thickness. Only two studies reported similarities in face processing abilities and perceived competence, and the interventional studies showed group similarities in behavior improvement, such as intelligence and attention. Conclusions Based on the articles reviewed, we conclude that while DCD and ASD share some behavioral symptoms, the symptom profiles of each disorder are unique and separable. We recommend that the evaluation of potential DCD in individuals with ASD be performed systematically and thoroughly, so as to distinguish this co-occurring condition from sensorimotor symptoms associated with ASD.

show abstract

“…Glazebrook and Wallace ( 2014 ), associate lesions to global connectivity with autism spectrum disorders. It is highly intriguing that some autism spectrum patients appear to share some of the characteristics with Kim Peek (and some other split-brain patients), even though clearly not autistic, including an seeming inability to deal with non-literal speech, prodigious attention to detail, and savant syndrome.…”

Section: Dynamical Representationsmentioning

confidence: 99%

“…The hubs and their interconnections may qualify as the architecture of the global workspace, whereas the modules they connect can be regarded as their client systems (see also Glazebrook and Wallace, 2014 for a similar proposal).…”

Section: Dynamical Representationsmentioning

confidence: 99%

What makes you think you are conscious? An agnosticist manifesto

Leeuwen

2015

Front. Hum. Neurosci.

View full text Add to dashboard Cite

The qualitative character of consciousness, its “what-it-is-likeness”, is a contested issue, both in philosophy and psychology. I argue that, rather than by conceptual analyses, the status of “what-it-is-likeness” has to be decided by empirical investigation. Pending the outcome, we should maintain an agnostic stance, in order to remove the bias in favor of fictionalism from our study of consciousness,. I illustrate this with the notion of “ownership unity”. People adhere to the belief of a single, unified self as the owner of their experiences, in spite of abundant dis-unities in the informational content of their experience. On one reading, this supports the notion that the unity of experience is no more than a convenient fiction, based on an illusory experience of unity. Cognitive neuroscience is slanted in favor of such understanding, insofar it emphasizes functional specialization and localization. To restore the balance, I present a complementary perspective: the view that the experience of unity is afforded by the intrinsic, multiscale brain dynamics. This approach offers a biological substrate for unity of experience as a regular scenario within certain boundary conditions, as well mechanisms that may let it go astray.

show abstract

Pathologies in functional connectivity, feedback control and robustness: a global workspace perspective on autism spectrum disorders

Cited by 12 publications

References 78 publications

Behavioral, perceptual, and neural alterations in sensory and multisensory function in autism spectrum disorder

Behavioral, perceptual, and neural alterations in sensory and multisensory function in autism spectrum disorder

Behavioral comparisons in Autism Spectrum Disorder and Developmental Coordination Disorder: A systematic literature review

What makes you think you are conscious? An agnosticist manifesto

Contact Info

Product

Resources

About