Pathologie der Papilla Vateri

Fischer, Hans‐Peter; Zhou, Hui

doi:10.1007/978-3-642-57036-0_25

Cited by 8 publications

(10 citation statements)

References 117 publications

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“…In very young patients13 and in ampullary carcinomas in twins,14 a genetic predisposition has to be supposed. Ampullary carcinomas are not infrequently associated with other primary malignant tumors, especially carcinomas of the gastrointestinal tract 1,5. Neurofibromatosis type I seems to be a predisposition not only for somatostatinomas of the papilla of Vater but also for ampullary carcinomas 16.…”

Section: Carcinoma Of the Papilla Of Vatermentioning

confidence: 99%

“…Many ampullary carcinomas develop from preexisting adenomas or flat preneoplastic lesions. Residual adenomatous areas can be found in 30% to 91% of ampullary carcinomas, 5 The great frequency range of carcinoma-associated adenomatous lesions reflects the difficulties in the morphologic analysis of ampullary mucosal proliferations, especially from biopsies.…”

Section: Precursor Lesions Of Ampullary Carcinomamentioning

confidence: 99%

“…Cigarette smoke is discussed to be a peristatic risk factor. Chronic infection by liver fluke is an important predisposition for this tumor type (for review, see reference 5 ). In very young patients 13 and in ampullary carcinomas in twins, 14 a genetic predisposition has to be supposed.…”

Section: Predisposition and Incidencementioning

confidence: 99%

“…Ampullary carcinomas are not infrequently associated with other primary malignant tumors, especially carcinomas of the gastrointestinal tract. 1,5 Neurofibromatosis type I seems to be a predisposition not only for somatostatinomas of the papilla of Vater but also for ampullary carcinomas. 16 The finding of two ampullary carcinomas in 205 reported cases of Muir-Torre syndrome, a condition characterized by the association of multiple sebaceous tumors and kerato-acanthomas with internal malignancies, suggests a higher prevalence in this syndrome than in the general population.…”

Section: Predisposition and Incidencementioning

confidence: 99%

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Pathogenesis of carcinoma of the papilla of Vater

Fischer

Zhou

2004

J Hepatobiliary Pancreat Surg

179

125

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Most adenomas and carcinomas of the small intestine and extrahepatic bile ducts arise in the region of the papilla of Vater. In familial adenomatous polyposis (FAP) it is the main location for carcinomas after proctocolectomy. In many cases symptoms due to stenosis lead to diagnosis at an early tumor stage. In about 80%, curative intended resection is possible. Operability is the most relevant prognostic factor. Most ampullary carcinomas resp. carcinomas of the papilla of Vater develop from adenomatous or flat dysplastic precursor lesions. They can be sited in the ampulloduodenal part of the papilla of Vater, which is lined by intestinal mucosa. They also can develop in deeper parts of the ampulla, which are lined by pancreaticobiliary duct mucosa. Intestinal-type adenocarcinoma and pancreaticobiliary-type adenocarcinoma represent the main histological types of ampullary carcinoma. Furthermore, there exist unusual types and undifferentiated carcinomas. Many carcinomas of intestinal type express the immunohistochemical marker profile of intestinal mucosa (keratin 7-, keratin 20+, MUC2+). Carcinomas of pancreaticobiliary type usually show the immunohistochemical profile of pancreaticobiliary duct mucosa (keratin 7+, keratin 20-, MUC2-). Even poorly differentiated carcinomas, as well as unusual histological types, may conserve the marker profile of the mucosa they developed from. These findings underline the concept of histogenetically different carcinomas of the papilla of Vater which develop either from intestinal- or from pancreaticobiliary-type mucosa of the papilla of Vater. Molecular alterations in ampullary carcinomas are similar to those of colorectal as well as pancreatic carcinomas, although they appear at different frequencies. In future studies, molecular alterations in ampullary carcinomas should be correlated closely with the different histologic tumor types. Consequently, the histologic classification should reflect the histogenesis of ampullary tumors from the two different types of papillary mucosa.

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Section: Carcinoma Of the Papilla Of Vatermentioning

confidence: 99%

Section: Precursor Lesions Of Ampullary Carcinomamentioning

confidence: 99%

Section: Predisposition and Incidencementioning

confidence: 99%

Section: Predisposition and Incidencementioning

confidence: 99%

See 2 more Smart Citations

Pathogenesis of carcinoma of the papilla of Vater

Fischer

Zhou

2004

J Hepatobiliary Pancreat Surg

179

125

View full text Add to dashboard Cite

show abstract

“…This is the most frequent site of adenomas and malignant tumors of the whole small intestine. In the same way, as in the colon, most ampullary carcinomas originate from preexisting adenomas with chromosomal instability, and develop through the process of carcinogenesis known as "adenoma-carcinoma" sequence [11].…”

Section: Carcinoma Of Ampulla Of Vater: Carcinogenesis and Immunophenmentioning

confidence: 99%