Pathologie de l’oreille

Wassef, Michel

doi:10.1016/j.annpat.2009.07.003

Cited by 5 publications

(1 citation statement)

References 73 publications

(61 reference statements)

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“…Our patient with progressive hearing loss was also type 2, which was consistent with a previous report. Other reports have also suggested that WS type 2 involves progressive HL [ 15 , 16 ]. Pingault et al stated that the genetic findings in WS 2 and 4 are more complex than those in WS 1 and 3, and that WS 2 and 4 are genetically heterogeneous [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

The Hearing Outcomes of Cochlear Implantation in Waardenburg Syndrome

Koyama

Kashio

Sakata

et al. 2016

BioMed Research International

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Objectives. This study aimed to determine the feasibility of cochlear implantation for sensorineural hearing loss in patients with Waardenburg syndrome. Method. A retrospective chart review was performed on patients who underwent cochlear implantation at the University of Tokyo Hospital. Clinical classification, genetic mutation, clinical course, preoperative hearing threshold, high-resolution computed tomography of the temporal bone, and postoperative hearing outcome were assessed. Result. Five children with Waardenburg syndrome underwent cochlear implantation. The average age at implantation was 2 years 11 months (ranging from 1 year 9 months to 6 years 3 months). Four patients had congenital profound hearing loss and one patient had progressive hearing loss. Two patients had an inner ear malformation of cochlear incomplete partition type 2. No surgical complication or difficulty was seen in any patient. All patients showed good hearing outcome postoperatively. Conclusion. Cochlear implantation could be a good treatment option for Waardenburg syndrome.

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Section: Discussionmentioning

confidence: 99%

The Hearing Outcomes of Cochlear Implantation in Waardenburg Syndrome

Koyama

Kashio

Sakata

et al. 2016

BioMed Research International

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Sex-specific association of RANTES gene −403 variant in Meniere’s disease

Yazdani

Mojbafan

Taleba

et al. 2014

Eur Arch Otorhinolaryngol

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Several studies have shown the correlation between RANTES gene and inflammatory disorders; the aim of the present study was to investigate the association between RANTES promoter gene polymorphism and Meniere's disease (MD) in an Iranian population. In this study patients with MD comprising definite MD (N = 56) and probable MD (N = 15) were selected according to diagnostic criteria of AAO-HNS. The control group (N = 101) were healthy normal subjects who did not have a history of ear disease and vertigo. PCR-RFLP for RANTES -403G>A has been performed. We found a protective role for RANTES -403A allele in male group in our population. None of the male patients with MD were carrier of allele A which was significantly different from the presence of allele A in the male control group (AA+GA vs. GG: p = 0.0004, OR 0.05, 95 % CI 0.001-0.39). This difference was not significant in female group. There was no significant association between RANTES gene polymorphism and the level of hearing loss. our results showed a sex-specific association between RANTES gene polymorphism and MD but more studies are necessary to further assess this association.

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