Pathological <sup>99m</sup>Tc-sestamibi myocardial perfusion scintigraphy is independently associated with emerging cardiac events in elderly patients with known or suspected coronary artery disease

Bucerius, Jan; Joe, Alexius; Herder, Ellen; Brockmann, Holger; Biermann, Kim; Palmedo, Holger; Tiemann, Klaus; Biersack, H. J.

doi:10.1258/ar.2010.090482

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…Also, higher SSS was linked to lower event-free survival rate [18]. Moreover, Bucerius et al had reported that higher SSS is independently associated with cardiac events and lower incidence of cardiac event-free survival in the elderly [19]. However, in patients with severe left ventricular (LV) systolic dysfunction (LV ejection fraction ≤35%), Gimelli et al showed that SSS is less predictive of outcome compared to patients with better preserved systolic dysfunction [20].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Prognostic Value of Automated Measurements in Nuclear Cardiology: Comparisons with Expert Scoring

Angelidis,

Giannakou,

Valotassiou

et al. 2023

Medicina

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Background and Objectives: Automated methods for the analysis of myocardial perfusion studies have been incorporated into clinical practice, but they are currently used as adjuncts to the visual interpretation. We aimed to investigate the role of automated measurements of summed stress score (SSS), summed rest score (SRS), and summed difference score (SDS) as long-term prognostic markers of morbidity and mortality, in comparison to the prognostic value of expert reading. Materials and Methods: The study was conducted at the Nuclear Medicine Laboratory of the University of Thessaly, in Larissa, Greece. A total of 378 consecutive patients with known or suspected coronary artery disease were enrolled in the study. All participants were referred to our laboratory for the performance of stress/rest myocardial perfusion single photon emission computed tomography. Automated measurements of SSS, SRS, and SDS were obtained by Emory Cardiac Toolbox (ECTb (Version 3.0), Emory University, Atlanta, GA, USA), Myovation (MYO, Xeleris version 3.05, GE Healthcare, Chicago, IL, USA), and Quantitative Perfusion SPECT (QPS (Version 4.0), Cedars-Sinai Medical Center, Los Angeles, CA, USA) software packages. Follow-up data were recorded after phone contacts, as well as through review of hospital records. Results: Expert scoring of SSS and SDS had significantly greater prognostic ability in comparison to all software packages (p < 0.001 for all comparisons). Similarly, ECTb-obtained SRS measurements had significantly lower prognostic ability in comparison to expert scoring (p < 0.001), while expert scoring of SRS showed significantly higher prognostic ability compared to MYO (p = 0.018) and QPS (p < 0.001). Conclusions: Despite the useful contribution of automated analyses in the interpretation of myocardial perfusion studies, expert reading should continue to have a crucial role, not only in clinical decision making, but also in the assessment of prognosis.

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Section: Discussionmentioning

confidence: 99%

Long-Term Prognostic Value of Automated Measurements in Nuclear Cardiology: Comparisons with Expert Scoring

Angelidis,

Giannakou,

Valotassiou

et al. 2023

Medicina

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Resultados de SPECT miocárdico y eventos cardiovasculares en dos servicios de Medicina nuclear de Bogotá durante 2011 a 2012

Garcia

2014

Revista Colombiana de Cardiología

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Pathological ^99mTc-sestamibi myocardial perfusion scintigraphy is independently associated with emerging cardiac events in elderly patients with known or suspected coronary artery disease

Abstract: Pathological MPS is independently associated with emerging cardiac events predicting a significantly lower incidence of cardiac event-free survival in patients aged ≥70 years.

Cited by 2 publications

References 21 publications

Long-Term Prognostic Value of Automated Measurements in Nuclear Cardiology: Comparisons with Expert Scoring

Long-Term Prognostic Value of Automated Measurements in Nuclear Cardiology: Comparisons with Expert Scoring

Resultados de SPECT miocárdico y eventos cardiovasculares en dos servicios de Medicina nuclear de Bogotá durante 2011 a 2012

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Pathological 99mTc-sestamibi myocardial perfusion scintigraphy is independently associated with emerging cardiac events in elderly patients with known or suspected coronary artery disease

Abstract: Pathological MPS is independently associated with emerging cardiac events predicting a significantly lower incidence of cardiac event-free survival in patients aged ≥70 years.

Cited by 2 publications

References 21 publications

Long-Term Prognostic Value of Automated Measurements in Nuclear Cardiology: Comparisons with Expert Scoring

Long-Term Prognostic Value of Automated Measurements in Nuclear Cardiology: Comparisons with Expert Scoring

Resultados de SPECT miocárdico y eventos cardiovasculares en dos servicios de Medicina nuclear de Bogotá durante 2011 a 2012

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Pathological ^99mTc-sestamibi myocardial perfusion scintigraphy is independently associated with emerging cardiac events in elderly patients with known or suspected coronary artery disease