Pathological PrP is abundant in sympathetic and sensory ganglia of hamsters fed with scrapie

McBride, Patricia; Beekes, Michael

doi:10.1016/s0304-3940(99)00223-2

Cited by 123 publications

(90 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Following up on experimental pathogenesis studies in mice (16)(17)(18)(19) and sheep (20), the animal model used in this study has provided key observations on the spread of infection through the body (4,(21)(22)(23)(24) that have been confirmed in naturally occurring ovine scrapie (25), field cases of BSE (26), orally transmitted BSE in primates (27), and orally transmitted or naturally occurring CWD (28,29). Additionally, more recent reports on the involvement of the sympathetic nervous system in vCJD (30) and the deposition of PrP Sc in muscles of patients with sporadic CJD (14) have shown the relevance of our hamster model for peripheral PrP Sc routing in TSE-affected humans.…”

Section: Introductionmentioning

confidence: 99%

Preclinical deposition of pathological prion protein PrPSc in muscles of hamsters orally exposed to scrapie

Thomzig¹,

Schulz‐Schaeffer²,

Kratzel³

et al. 2004

J. Clin. Invest.

Self Cite

View full text Add to dashboard Cite

Recently, pathological prion protein PrP Sc , the putative key constituent of infectious agents causing transmissible spongiform encephalopathies (TSEs), was found in muscles of rodents experimentally infected with scrapie and in patients with Creutzfeldt-Jakob disease (CJD). For the assessment of risk scenarios originating from these findings (e.g., alimentary transmission of pathogens associated with bovine spongiform encephalopathy [BSE]

show abstract

Section: Introductionmentioning

confidence: 99%

Preclinical deposition of pathological prion protein PrPSc in muscles of hamsters orally exposed to scrapie

Thomzig¹,

Schulz‐Schaeffer²,

Kratzel³

et al. 2004

J. Clin. Invest.

Self Cite

View full text Add to dashboard Cite

show abstract

“…In contrast, sheep deliberately challenged with BSE display PrP Sc in a broad range of tissues including the lymphoid system, parts of the digestive tract and in the peripheral nervous system [29]. The distribution of infectivity in these BSE affected sheep is similar to that observed in sheep of similar PrP-genotype infected with scrapie [9, 42,62,63]. The spread of PrP Sc to the lymphoid organs is thought to be mediated by the lymphoreticular system.…”

Section: Introductionmentioning

confidence: 93%

“…The spread of PrP Sc to the lymphoid organs is thought to be mediated by the lymphoreticular system. Studies have shown that the eventual transport of PrP Sc to the CNS is mediated by axonal transport within the parasympathetic and the sympathetic nervous system [4,62,63,109,115,116].…”

Section: Introductionmentioning

confidence: 99%

The use of non-prion biomarkers for the diagnosis of Transmissible Spongiform Encephalopathies in the live animal

Parveen

Moorby²,

Allison³

et al. 2005

Vet. Res.

View full text Add to dashboard Cite

-Scrapie and bovine spongiform encephalopathy (BSE) are major global concerns and the emergence of variant Creutzfeldt-Jakob disease (vCJD) has caused turmoil for blood transfusion services and hospitals worldwide. Recent reports of iatrogenic CJD (iCJD) cases following blood transfusions from Transmissible Spongiform Encephalopathies (TSE)-infected donors have fuelled this concern. Major diagnostic tests for BSE and scrapie are conducted post-mortem from animals in late stages of the disease. Although the lymphoreticular system is involved in the earlier pathogenesis of some forms of sheep scrapie and vCJD, which presents great opportunity for diagnostic development, other TSE diseases (some strains of scrapie, sporadic CJD (sCJD) and bovine BSE) do not present such a diagnostic opportunity. Thus, there is an urgent need for premortem tests that differentiate between healthy and diseased individuals at early stages of illness, in accessible samples such as blood and urine using less invasive procedures. This review reports on the current state of progress in the development and use of prion and non-prion biomarkers in the diagnosis of TSE diseases. Some of these efforts have concentrated on improving the sensitivity of PrP Sc detection to allow in vivo diagnosis at low abundances of PrP Sc whilst others have sought to identify non-prion protein biomarkers of TSE disease, many of which are still at early stages of development. In this review we comment upon the limitations of prion based tests and review current research on the development of tests for TSE that rely on non-prion disease markers in body fluids that may allow preclinical disease diagnosis.

show abstract

“…Deux circuits de dépôt de PrP Sc ont été décrits : les circuits sympathique et parasympathique [36]. Le premier compartiment du SNP responsable de la neuro-invasion est représenté par les nerfs sympathiques comme le nerf splanchnique [25]. À la suite d'une sympathectomie, le transport de la PrP Sc des organes lymphoïdes vers la moelle épinière est retardé [26].…”

Section: Propagation De L'agent Pathogène Du Système Nerveux Périphérunclassified

Les prions exploitent les communications neuro-immunitaires

2010

View full text Add to dashboard Cite

Pathological PrP is abundant in sympathetic and sensory ganglia of hamsters fed with scrapie

Cited by 123 publications

References 16 publications

Preclinical deposition of pathological prion protein PrPSc in muscles of hamsters orally exposed to scrapie

Preclinical deposition of pathological prion protein PrPSc in muscles of hamsters orally exposed to scrapie

The use of non-prion biomarkers for the diagnosis of Transmissible Spongiform Encephalopathies in the live animal

Les prions exploitent les communications neuro-immunitaires

Contact Info

Product

Resources

About