Pathological prognostic factors in the second British Stomach Cancer Group trial of adjuvant therapy in resectable gastric cancer

Yu, Cheng‐Ju; Levison, David A.; Dunn, Janet A.; Ward, LC; Demonakou, Maria; Allum, William; Hallisey, M. T.

doi:10.1038/bjc.1995.214

Cited by 56 publications

(40 citation statements)

References 18 publications

(9 reference statements)

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“…While the prognostic significance of poorly differentiated histology in gastric cancer is controversial, several studies have demonstrated that mixed type in Lauren's classification is associated with poor prognosis and other factors suggesting aggressive biologic behavior such as lymph node metastasis and advanced stage (Shiu et al, 1989;Kim et al, 1992;Carneiro et al, 1995;Macdonald et al, 1995;Yu et al, 1995;Setälä et al, 1996;Stelzner and Emmrich, 1997). Unlike the present results, other studies with gastric cancer tissue have failed to show any relationship between TS expression and tumour differentiation or Lauren's classification (Kuniyasu et al, 1998;Yeh et al, 1998;Suda et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Expression of thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection

Lim

Nam

et al. 2001

Br J Cancer

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SummaryWe evaluated the expression of thymidylate synthase (TS) in locally advanced gastric cancer patients treated with adjuvant chemotherapy after curative resection and investigated the association between TS expression and clinicopathologic characteristics including prognosis of the patients. TS expression was evaluated by immunohistochemical staining using TS106 monoclonal antibody in 103 locally advanced gastric cancer patients (stage IB-IV) who underwent 5-fluorouracil (5-FU) and doxorubicin-based adjuvant chemotherapy after curative resection. 65 patients (63%) had primary tumours with high TS expression (≥ 25% of tumour cells positive), and 38 patients (37%) demonstrated low TS expression (< 25% of tumour cells positive or no staining). High TS expression was associated with male gender (P = 0.002), poorly differentiated histology (P = 0.015), and mixed type in Lauren's classification (P = 0.027). There were no statistically significant differences in 4-year disease-free survival (60.0% vs 57.2%, P = 0.548) and overall survival (59.6% vs 59.3%, P = 0.792) between high-TS group and low-TS group. In conclusion, although high TS expression was associated with poorly differentiated histology and mixed type in Lauren's classification, it did not predict poor disease-free and overall survival in gastric cancer patients treated with 5-FU and doxorubicin-based adjuvant chemotherapy after curative resection. Further prospective studies including the evaluation of other biological markers associated with the resistance to 5-FU and doxorubicin are necessary. 186-192 © 2001 Cancer Research Campaign doi: 10.1054/ bjoc.2000.1553, available online at http://www.idealibrary.com on http://www.bjcancer.com based adjuvant chemotherapy after curative surgical resection at Ajou University Medical Center in Suwon, Korea, between July 1994 and October 1996. All patients had a postsurgical pathologic stage ranging from IB to IV without evidence of distant metastasis according to the American Joint Committee on Cancer TNM classification (American Joint Committee on Cancer, 1997). Curative resection was defined by the General Rules for the Gastric Cancer Study in Surgery and Pathology of the Japanese Research Society for Gastric Cancer as: no involvement of surgical stumps; sufficient lymphatic dissection (R number ≥ N number); no distant metastasis; removal of involved adjacent organs and structures by combined en-bloc resection; and no gross residual disease (Japanese Research Society for Gastric Cancer, 1981). None of these patients received chemotherapy prior to surgery.Although all patients received 5-FU and doxorubicin-based adjuvant chemotherapy, the regimens were not uniform. The most commonly administered regimen was FA (5-FU, doxorubicin) with OK-432 (51 patients), followed by FAM (5-FU, doxorubicin, mitomycin-C) (33 patients), FA (11 patients), and FA with lentinan (eight patients). Chemotherapy was usually started 2-3 weeks after surgery. In the FA regimen with or without immunotherapy (OK-432 or lentinan), 5-FU (...

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Section: Discussionmentioning

confidence: 99%

Expression of thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection

Lim

Nam

et al. 2001

Br J Cancer

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“…The commonest pattern of disease failure among patients who underwent curative D2 dissection in the Far East is peritoneal carcinomatosis [2,3]. Attempts to improve the outcome of patients who have this morbid condition remain a significant challenge, and the development of novel therapeutic modalities and approaches is urgently required.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of plasma treatment on gastric cancer cells

et al. 2014

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Background Treatment of peritoneal carcinomatosis arising from gastric cancer remains a considerable challenge. In recent years, the anticancer effect of nonequilibrium atmospheric pressure plasma (NEAPP) has been reported in several cancer cell lines. Use of NEAPP may develop into a new class of anticancer therapy that augments surgery, chemotherapy, and radiotherapy. Method Gastric cancer cells were assessed for changes in cell morphology and rate of proliferation after treatment with NEAPP-exposed medium (PAM). To explore the functional mechanism, caspase 3/7, annexin V, and uptake of reactive oxygen species (ROS) were evaluated, along with the effect of the ROS scavenger N-acetylcysteine (NAC). Results PAM treatment for 24 h affected cell morphology, suggestive of induction of apoptosis. PAM cytotoxicity was influenced by the time of exposure to PAM, the type of cell line, and the number of cells seeded. Cells treated with PAM for 2 h demonstrated activated caspase 3/7 and an increased proportion of annexin V-positive cells compared with untreated cells. Additionally, ROS uptake was observed in PAM-treated cells, whereas NAC reduced the cytotoxicity induced by PAM presumably through reduction of ROS uptake. Furthermore, CD44 variant 9, which reportedly leads to glutathione synthesis and suppresses stress signaling of ROS, was overexpressed in PAM-resistant cells. Conclusions PAM treatment induced apoptosis of gastric cancer cells through generation and uptake of ROS. Local administration of PAM could develop into an option to treat peritoneal carcinomatosis.

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“…Dockerty [19] reported that the 5-year survival was 100% for tumor invasion just to the mucous membrane, 61% for tumors passing through the mucous membrane, 44% for tumors invading the entire stomach wall, and 15% for tumors with nodal distribution. The British Study Group analysed the tumor site, gross appearance of the tumor, the number of involved lymph nodes, depth of tumor invasion, the nodal stage, and the tumor grade, and concluded that depth of tumor invasion, lymph node involvement, and positive surgery borders were prognostic factors [20]. According to the univariate analysis of our patients, the increased depth of tumor invasion has an adverse effect on survival.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors that Affect the Survival of Gastric Cancer

Yücel¹,

Kılıçkap²,

Okur³

et al. 2012

CMJ

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Aims. The purpose of this study is to review the factors that affect the survival and clinicopathological characteristics of gastric cancer cases monitored and treated at our centre. Method. 112 gastric cancer patients who admitted to the Radiation Oncology Department of Cumhuriyet University Medical Faculty Research and Application Hospital between 2006 and 2010 were included in the study. The demographic, clinical, and histopathology data of the patients were obtained from the patient files and the hospital records. Results. This study analysed data of 112 patients of whom 90 (80%) were men, and 22 (20%) were women. The factors that determined survival were stage of the cancer, T and N stages, high grade, performance status, presence of anemia and hypoalbuminemia, presence of metastasis, extravascular invasion, weight loss, metastatic lymph node ratio (>50%) and a high level of serum CEA and CA19-9. The stage, performance status, anemia at the time of diagnosis were determined as independent prognostic factors that affect survival after performing multivariate analysis. Conclusion. Many studies have defined numerous prognostic factors for gastric cancer. In concordance with the literature, this study sets forth that the most important factors in terms of prognosis are the stage, the performance status, and the presence of anemia at diagnosis the time of diagnosis.

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Pathological prognostic factors in the second British Stomach Cancer Group trial of adjuvant therapy in resectable gastric cancer

Cited by 56 publications

References 18 publications

Expression of thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection

Expression of thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection

Effectiveness of plasma treatment on gastric cancer cells

Prognostic Factors that Affect the Survival of Gastric Cancer

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