Pathological nature of renal tumors - does size matter?

Kurban, Lutfi; Vosough, Alireza; Jacob, Preman; Prasad, Deepak; Lam, Thomas; Scott, Norman; Somani, Bhaskar K.

doi:10.4103/ua.ua_17_17

Cited by 15 publications

(10 citation statements)

References 23 publications

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“…The role of a percutaneous needle biopsy appears also promising in the management of SRM. If the biopsy confirms the presence of a non-malignant lesion, surgical intervention or even a follow-up could be potentially avoided [8]. A common outcome is that the lesion is not a tumor at all.…”

Section: Active Surveillancementioning

confidence: 99%

Active surveillance and focal ablation for small renal masses: a better solution for comorbid patients

Wośkowiak

Lewicka

Bureta

et al. 2020

aoms

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The natural history of small renal masses (SRM) is still not well understood and they are frequently incidentally diagnosed in elderly patients. Therefore, there is a need for less invasive options sparing the patient from the side-effects related to conventional surgical treatment. PubMed and Medline database search was performed to look for new findings on active surveillance and focal therapy for SRM. Sixty-one articles published between 2002 and 2018 were selected for the purpose of the review. There is growing evidence confirming the safety of active surveillance in patients at surgical risk and there appears to be a satisfactory intermediate-term outcome of focal treatment of SRM. In the group of elderly patients with a decreased life expectancy active surveillance appears to be the most appropriate approach. The future of minimally invasive therapy appears bright, especially with the improvement of new imaging modalities.

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Section: Active Surveillancementioning

confidence: 99%

Active surveillance and focal ablation for small renal masses: a better solution for comorbid patients

Wośkowiak

Lewicka

Bureta

et al. 2020

aoms

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“…Lastly, by equating the same powers of ϵ 2 in (19)(20)(21)(22) and accounting for ansätze (27) and (28), we obtain…”

Section: Differential Conditions For ϵ 2 and The Resulting Darcy's Ty...mentioning

confidence: 99%

“…[cm] R = 0.5 − 5 [33], [38], [39], [21] Hydraulic conductivity [cm 2 /s/mmHg] K 0 = 2.5 × 10 Charge density constant [A/cm 2 ] c = 0.0004 − 0.25 [37], [3] Electric őeld [V /cm] E = 140 − 1000 [20], [9], [26], [7] Table 1. Parameter values exploited for modelling…”

Section: Hydraulic Conductivitymentioning

confidence: 99%

Multiscale modelling of fluid transport in vascular tumours subjected to electrophoresis anti-cancer therapies

Fülöp,

Penta,

Ramírez-Torres

2023

Preprint

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Electrophoresis facilitated cancer treatment has demonstrated experimental efficacy in enhancing drug delivery within vascularised tumours. However, the lack of realistic mathematical models with direct measurements in the context of eletrochemotheraphy poses a challenge. We investigate the impact of an applied electric potential on the flow of Darcian-type fluid occurring in two distinct phases: the tumour and healthy regions. We employ the asymptotic homogenisation technique, assuming that the macroscale of the tumour domain is larger than the microscale characterised by vessel heterogenities. We retain information about the microstructure by encoding information in the homogenised coefficients. We take into account both vascularisation and the microscale variations of the leading order and fine scale electric potential. The resulting effective differential problem reads as a Darcy-type system of PDEs, where the flow is driven by an effective source. The novel model can be used to predict the effect of an applied electric field on cancerous biological tissues, paving a new way of improving current electrochemotherapy protocols.

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“…Renal masses ≥4 cm are much more often malignant than the smaller ones and more often a high-grade RCC [18]. This may justify the entirely different management of larger renal masses – they are in majority qualified to surgical intervention without previous biopsy.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-Guided Renal Mass Biopsy and Its Clinical Utility: A Single-Centre Experience

Jasiński¹,

Siekiera²,

Tworkiewicz³

2022

Urol Int

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Introduction: Renal mass biopsy (RMB) is still underutilized, partially because many urologists argue that it does not substantially influence the management of renal masses. We sought to evaluate the influence of RMB on the management of renal tumours in our institution. Materials and Methods: A total of 387 RMBs performed at our institution from January 2016 to June 2020 were included. Patient demographics, mass size, biopsy result, and subsequent clinical management were retrospectively reviewed. Results: The mean mass size was 47.8 mm. Fifty-six percentage of tumours ≤40 mm (247) and 8% of tumours >40 mm (64) were biopsied. Seventy-six RMBs of disseminated tumours were performed. 14.9% of RMBs were non-diagnostic, and 27.1% of RMBs of tumours ≤40 mm were benign. The majority of tumours with first non-diagnostic RMB followed by histopathological verification were found to be malignant. There was significantly more conservative management and no radical nephrectomies in the benign biopsy group. One case of Clavien-Dindo grade ≥2 complication occurred. Conclusions: RMB result affects treatment decisions. Ultrasound-guided RMB is a safe procedure, and performing biopsies of tumours ≤40 mm may reduce the number of unnecessary interventions. Non-diagnostic RMBs should be repeated or treated as malignant.

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Pathological nature of renal tumors - does size matter?

Cited by 15 publications

References 23 publications

Active surveillance and focal ablation for small renal masses: a better solution for comorbid patients

Active surveillance and focal ablation for small renal masses: a better solution for comorbid patients

Multiscale modelling of fluid transport in vascular tumours subjected to electrophoresis anti-cancer therapies

Ultrasound-Guided Renal Mass Biopsy and Its Clinical Utility: A Single-Centre Experience

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