Pathological laughter in a patient with Rathke cleft cyst

Cao, Zhikai; Liu, Jianping; Ding, Zhengbin; Du, Hong

doi:10.1016/j.jocn.2007.08.030

Cited by 8 publications

(3 citation statements)

References 24 publications

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“…Furthermore, precocious puberty, occurring in 8%‐35% of patients, is another characteristic endocrine manifestation in the paediatric‐adolescent population, whereas DI (3%‐26%) and hyperprolactinemia (2%‐20%) are less frequent 192,193,197‐205 . Rare presenting manifestations in adolescents include seizures, 192,197,198,203 syncope, 197,206 weight gain, 192,198 aseptic meningitis, 192 pathological laughter, 207 ataxia, 207 dizziness 197 and tinnitus 197 …”

Section: Rathke Cleft Cystmentioning

confidence: 99%

A clinical approach to parasellar lesions in the transition age

Sbardella

Puliani

Feola

et al. 2021

J Neuroendocrinology

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Many reviews have summarised the pathology and management of the parasellar region in adult patients, although an analysis of these aspects in the transition years, from puberty onset to the age of peak bone mass, has been lacking. A comprehensive search of English‐language original articles, published from 2000 to 2020, was conducted in the MEDLINE database (December 2019 to March 2020). We selected all studies regarding epidemiology, diagnosis and management of the following parasellar lesions: germinoma, craniopharyngioma, Langerhans cell histiocytosis, optic glioma, hypothalamic hamartoma, tuber cinereum hamartoma, cranial chordoma, Rathke cleft cyst, hypophysitis and hypothalamitis during the transition age from childhood to adulthood. In the present review, we provide an overview of the principal parasellar lesions occurring in the transition age. Symptoms are usually a result of the mass effect of the lesions on nearby structures, as well as anterior pituitary deficits. Diabetes insipidus occurs frequently in these patients. In this age group, pubertal developmental disorders may be more evident compared to other stages of life. Parasellar lesions in the transition age mostly include neoplastic lesions such as germinomas, hamartomas, optic gliomas, craniopharyngiomas Langerhans cell histiocytosis and chordomas, and rarely inflammatory lesions (hypophysitis, hypothalamitis). There are limited data on the management of parasellar lesions in the transition age. Endocrine evaluation is crucial for identifying conditions that require hormonal treatment so that they can be treated early to improve the quality of life of the individual patient in this complex age range. The clinical approach to parasellar lesions involves a multidisciplinary effort.

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Section: Rathke Cleft Cystmentioning

confidence: 99%

A clinical approach to parasellar lesions in the transition age

Sbardella

Puliani

Feola

et al. 2021

J Neuroendocrinology

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“…25 Aseptic meningitis followed by visual loss has been rarely reported in adults 5,22 and children 21 and is attributed to rupture of the cystic content into the subarachnoid space or to extension of the inflammation into surrounding structures. 22 Other rarely described presenting manifestations include sphenoid sinusitis, syncope, seizures, 5,16 ataxia, 57 mood disturbance 16,57 and precocious puberty.…”

Section: Presenting Manifestationsmentioning

confidence: 99%

Rathke’s cleft cysts

Trifănescu

Ansorge

Wass

et al. 2012

Clinical Endocrinology

138

120

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SummaryRathke's cleft cysts (RCCs) are benign, sellar and/or suprasellar lesions originating from the remnants of Rathke's pouch. Although a common finding in routine autopsies (12-33% of normal pituitary glands), symptomatic cases are rare and comprise 5-15% of all surgically resected sellar lesions. Small, asymptomatic RCC do not require surgical intervention, and their natural history is not clear. In series of nonoperated presumed RCCs, 26-94% did not progress during follow-up periods up to 9 years. In symptomatic ones, surgery is indicated, aiming to drain the cyst content and safely remove as much of the capsule as possible. Following surgical intervention, headaches and visual field defects improve or resolve in a significant number of patients (40-100% and 33-100%, respectively) and partial hypopituitarism recovers in 14-50%. Data on relapse rates published in the last 15 years are based on variable follow-up periods and show wide variation (between 0% and 33%). The lowest relapse rates have been described in reports with relatively short mean observation periods (<3 years), whereas in those with longer follow-up the relapse rates increase. Most of the relapses occur within 5-6 years, suggesting that follow-up is required for at least 5 years after surgery. Risk factors for relapse include the presence of squamous metaplasia in the cyst wall, cyst size and the presence of inflammation. Long-term sufficiently powered studies aiming to clarify the natural history of asymptomatic RCCs and of those relapsing postoperatively are required.

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“…The occurrence of PBA has been reported in a multitude of neurologic illnesses including, but not limited to, ALS, [15][16][17][18][19] PD and other movement disorders, 13,[20][21][22] MS, [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] stroke, [38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] various types of dementia and other neurodegenerative disorders, 55-62 traumatic brain injury (TBI), 63-66 central nervous system tumors, [67][68][69][70][71][72][73][74]...…”

Section: Epidemiologymentioning

confidence: 99%

The epidemiology and pathophysiology of pseudobulbar affect and its association with neurodegeneration

King¹,

Reiss²

2013

DNND

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Pseudobulbar affect is a disorder resulting from neurologic damage manifesting as sudden, stereotyped affective outbursts that are not reflective of internal emotion. A literature review was completed to examine the current understanding of the epidemiology, characterization, diagnosis, pathophysiology, and treatment of pseudobulbar affect. This review revealed that it is common in neurodegenerative disorders but is poorly recognized, placing significant impacts on patients and their families. The disorder appears to result from a disruption of the cortico-limbicsubcortical-thalamic-pontocerebellar network involved in emotional expression and regulation with resulting disruptions of neurotransmitter systems. Effective treatment is available with agents such as selective serotonin reuptake inhibitors and dextromethorphan combined with quinidine, but further well-designed comparative studies are needed. Advances in technology such as neuroimaging may enhance knowledge about the pathophysiology of this disorder, and help guide future interventions.

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Pathological laughter in a patient with Rathke cleft cyst

Cited by 8 publications

References 24 publications

A clinical approach to parasellar lesions in the transition age

A clinical approach to parasellar lesions in the transition age

Rathke’s cleft cysts

The epidemiology and pathophysiology of pseudobulbar affect and its association with neurodegeneration

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