Pathological findings in cornea tissue of patients with penetrating keratoplasty.

Kostelná, Helga; Rosocha, Ján; Paulíková, E; Kozak, Igor; Antalová, Mária; Mahel, Martin; Harvanová, Denisa; Petrovicová, J; Bobak, L

doi:10.2478/v10042-010-0002-6

Cited by 2 publications

(2 citation statements)

References 14 publications

(16 reference statements)

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“…36,37 Immune infiltrates are usually seen along multiple suture tracks, along the host side of the graft-host interface, and have no overlying epithelial defect compared with infectious infiltrates. 38 The treatment of suture-related infections begins with removal and culture of the suture. Running sutures pose a particular challenge as premature removal of the suture prior to proper would healing can lead to wound dehiscence.…”

Section: Suture-related Complicationsmentioning

confidence: 99%

Early Complications After Penetrating Keratoplasty

Haidara¹,

Jeng²

2016

US Ophthalmic Review

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Although endothelial keratoplasty has gained increasing popularity over the last decade in the US, penetrating keratoplasty (PK) continues to have a role in the treatment of corneal diseases. This is especially true in developing nations where endothelial keratoplasty has not been popularized, and where isolated endothelial disease is much less common. In these situations, PK is still indicated. As with any surgical procedure, PK carries with it complications that can threaten the success of the procedure, including wound-related issues, ocular surface disease, infections, and suture-related complications. This article will review the various aspects of early complications after PK occurring within the first 2 months of surgery, along with management techniques. A review of the current literature was performed via a Medline search using the keywords “penetrating keratoplasty,” “complications,” “cornea,” and “transplant.” All articles containing descriptions of early postoperative complications after PK were reviewed, and the more commonly encountered complications are discussed in this article.

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Section: Suture-related Complicationsmentioning

confidence: 99%

Early Complications After Penetrating Keratoplasty

Haidara¹,

Jeng²

2016

US Ophthalmic Review

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“…Early diagnosis of corneal graft rejection and/or failure has been a challenge for many researchers, and histological in vivo and ex vivo studies have demonstrated progress on this issue [6–10]. However, studies regarding the Descemet's membrane (DM, the true basal membrane of the cornea) remain scarce.…”

Section: Introductionmentioning

confidence: 99%

The Use of Digital Microscopy to Compare the Thicknesses of Normal Corneas and Ex Vivo Rejected Corneal Grafts with a Focus on the Descemet’s Membrane

Tognon

Bergeron

Mastromonaco

et al. 2019

Journal of Ophthalmology

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Objective To compare the thickness of corneal layers, specifically the Descemet's membrane (DM), in normal corneas and in failed grafts due to rejection (FGRs) using the digital histopathology and to propose a model for the measurement of corneal layers using this method. Methods This is a prospective, cross-sectional study performed at the MUHC-McGill University Ocular Pathology & Translational Research Laboratory (McGill University, Montreal, Canada). Histopathological sections of 25 normal human corneas and 40 FGRs were fully digitalized and examined. Inclusion criteria: samples diagnosed as normal corneas or FGRs, from patients older than 18 years of age. Exclusion criteria: histopathological sections without adequate tissue or missing epidemiological information. For each sample, the thicknesses of the epithelium, stroma, and DM were acquired. From a perpendicular plane of reference, two central measurements and two nasal and two temporal peripheral measurements were obtained. Results There were differences between the normal and FGR groups in the mean central thickness of the epithelium (p < 0.001), the nasal and temporal stromal regions (p < 0.001), and of the DM in the nasal and temporal regions (p < 0.001). Compared with the extremities of the sample (nasal and temporal), the mean thickness of the DM in normal corneas was lower in the central region (p < 0.001), and this difference was not found in the FGR group. Conclusions Normal corneas have a thinner epithelium in the central region than the FGR group. In addition, the stroma and DM thicknesses of the nasal and temporal periphery were significantly higher in normal corneas than in those from the FGR group. The digital microscopy protocol applied in this study may be useful for further research studies regarding cornea and other tissues.

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Pathological findings in cornea tissue of patients with penetrating keratoplasty.

Cited by 2 publications

References 14 publications

Early Complications After Penetrating Keratoplasty

Early Complications After Penetrating Keratoplasty

The Use of Digital Microscopy to Compare the Thicknesses of Normal Corneas and Ex Vivo Rejected Corneal Grafts with a Focus on the Descemet’s Membrane

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