Pathological Features of Mycobacterium kansasii Infection in Black Bearded Sakis (Chiropotes satanas)

Murai, Atsuko; Murakami, Tomoaki; Inoue, M.; Ueda, Hideaki; Shiihara, S.; Kimura, Junko; Hirata, Akihiko; Sakai, Hiroki; Yanai, Tokuma

doi:10.1016/j.jcpa.2012.02.006

Cited by 6 publications

(7 citation statements)

References 11 publications

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“…Subclinical cases of M. kansasii may not be identified if subtle lesions are not detected or respiratory disease is not suspected. Most of the previously reported cases of M. kansasii in non-domestic species have been those that had clinical signs of disease (Bercovier and Vincent 2001, Pressler and others 2002, Hall and others 2005, Waters and others 2006, Miller and Terrell 2011, Murai and others 2012, Rocha and others 2013). …”

Section: Discussionmentioning

confidence: 99%

Mycobacterium kansasii infection in a captive Sichuan takin (Budorcas taxicolortibetana) and a siamang (Hylobates syndactylus) at a zoological facility

Thompson

Campbell

Levens

et al. 2016

Vet Record Case Reports

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Mycobacterium kansasii is one of the most significant causes of pulmonary disease due to non-tuberculous mycobacteria in humans and has been recognised to cause disease in a wide variety of animal species. To the authors’ knowledge, this paper reports the first cases of pulmonary lesions due to M. kansasii in a siamang (Hylobates syndactylus) and a Sichuan takin (Budorcas taxicolor tibetana). In both cases, the animals had a history of a primary chronic disease that may have resulted in altered immune function and contributed to the development of secondary lesions due to M. kansasii. This report describes two cases that occurred at the same zoological facility, on different sides of the park and separated by a six-year time span.

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Section: Discussionmentioning

confidence: 99%

Mycobacterium kansasii infection in a captive Sichuan takin (Budorcas taxicolortibetana) and a siamang (Hylobates syndactylus) at a zoological facility

Thompson

Campbell

Levens

et al. 2016

Vet Record Case Reports

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“…It is considered an important pathogen causing pulmonary and cutaneous disease in people . Although there have been some reports in wild animals with disseminated M kansasii infection, there was only one report of a dog . This organism is usually not transmitted between individuals .…”

Section: Discussionmentioning

confidence: 99%

Mastitis caused byMycobacterium kansasiiinfection in a dog

Murai

Maruyama

Nagata³

et al. 2013

Veterinary Clinical Pathol

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A 2-year, 7-month-old female Chihuahua was admitted for a mammary mass measuring one cm in diameter. The dog had a history of demodicosis for 4 months and showed signs of pseudopregnancy at the time of the visit. Cytologic examination of an aspirate of the mass revealed a large number of macrophages containing nonstaining bacterial rods, which were acid-fast in a Ziehl-Neelsen stain, suggesting mycobacterial infection. Histologic examination of the mass revealed a pyogranulomatous mastitis characterized by an infiltration with macrophages containing acid-fast bacteria. Mycobacterium kansasii was subsequently cultured and identified by PCR. Surgical excision of the mass resulted in the growth of other dermal masses, but antimycobacterial treatment with rifampin and clarithromycin resolved these masses within 1 month. Three months after discontinuation of the treatment, similar organisms were found in aspirates of the enlarged bilateral inguinal lymph nodes by cytologic examination. Despite antimycobacterial treatment for another 4 months, there was no improvement and demodicosis also recurred. The dog eventually died of lymphoma 5 months after the relapse of mycobacterial infection. Although M kansasii is considered an important pathogen for pulmonary and cutaneous disease in people, there is only one report in a dog with an infection in a pleural effusion. As both adult-onset demodicosis in dogs as well as mycobacterial infection in people have been associated with T-lymphocyte deficiency, the M kansasii infection in this dog may have been associated with a condition of immune compromise.

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“…Mycobacteria incorporate > 180 species of aerobic microorganisms, including those within the Mycobacterium tuberculosis complex (MTC), which can cause pulmonary, disseminated, or cutaneous disease in humans and animals. 4,10 Broad classification of mycobacteria includes > 100 species of non-tuberculosis mycobacteria (NTM) that are ubiquitous in the environment and are found in soil, water, dust, and feed material. 4 Many of these NTM are opportunistic pathogens capable of causing clinical disease indistinguishable from tuberculosis-like disease, necessitating identification through bacterial culture or molecular testing.…”

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confidence: 99%

“…5 Other species in which clinical disease associated with M. kansasii infection has been reported include: domestic (Sus scrofa domesticus) and feral (S. scrofa) swine, cattle (Bos taurus), camels (Camelus dromedarius), a domestic cat (Felis catus), 2 dogs (Canis lupus familiaris), a llama (Lama glama), an alpaca (Vicugna pacos), 2 bonteboks (Damaliscus pygargus dorcas), a goat (Capra hircus), Florida manatees (Trichechus manatus latirostris), rhesus macaques (Macaca mulatta), squirrel monkeys (Saimiri sciureus), ring-tailed coatis (Nasua nasua), and 2 black-bearded sakis (Chiropotes satanas). [1][2][3][4][5][6]8,10,12,13 Immunosuppression with or without identification of a primary cause of disease was often suspected or confirmed in these affected animals. Consistently documented lesions in these cases were granulomas in the pulmonary parenchyma or thoracic wall.…”

mentioning

confidence: 99%

“…This is demonstrated in a report of disseminated granulomas in 2 black-bearded sakis in a zoologic park with no histologic evidence of acid-fast bacteria; identification of M. kansasii was made solely through PCR. 10 Bacterial culture is another appropriate way to determine species of Mycobacterium; however, in time-sensitive cases, molecular testing is preferred. This is particularly important in cases for which a bacterium within the MTC is a possible differential diagnosis, based on the potential threat to the health of agricultural animals or humans.…”

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confidence: 99%

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Disseminated Mycobacterium kansasii infection in a white-tailed deer and implications for public and livestock health

et al. 2019

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We document a case of Mycobacterium kansasii, a rare, zoonotic bacterium, in a white-tailed deer (WTD; Odocoileus virginianus) in East Baton Rouge Parish, Louisiana. Grossly, the deer had fibrinous pleuropneumonia with yellow, mineralized nodules scattered throughout the lungs and extending to the pleura. The kidneys were enlarged and had numerous pale foci in the cortex. Microscopically, the pulmonary architecture was replaced by variably sized, multifocal-to-coalescing granulomas with peripheral histiocytes and fewer multinucleate giant cells, and necrotic centers with mineralization and hemorrhage. The latter rarely contained one to a few acid-fast, slender, 7-µm long bacteria, for which beaded morphology was sometimes evident. Similar acid-fast bacteria were also within histiocytes in the kidney. PCR assay of fresh lung sample and subsequent sequencing revealed a non-tuberculosis mycobacterium, M. kansasii. These lesions were similar to those that result from infection with M. bovis in WTD. Both M. bovis and M. kansasii are zoonotic. WTD are a reservoir of M. bovis, which is a major concern in regions in which WTD and cattle can come into close contact.

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Pathological Features of Mycobacterium kansasii Infection in Black Bearded Sakis (Chiropotes satanas)

Cited by 6 publications

References 11 publications

Mycobacterium kansasii infection in a captive Sichuan takin (Budorcas taxicolortibetana) and a siamang (Hylobates syndactylus) at a zoological facility

Mycobacterium kansasii infection in a captive Sichuan takin (Budorcas taxicolortibetana) and a siamang (Hylobates syndactylus) at a zoological facility

Mastitis caused byMycobacterium kansasiiinfection in a dog

Disseminated Mycobacterium kansasii infection in a white-tailed deer and implications for public and livestock health

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