Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan

Liu, Shih–An; Wang, Chen‐Chi; Jiang, Rong–San; Lee, Fang-Yi; Lin, Wen-Dar; Lin, Jin‐Ching

doi:10.1038/s41598-017-08022-w

Cited by 62 publications

(54 citation statements)

References 30 publications

(46 reference statements)

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“…Retrospective studies have posited PNI as a predictor or higher rates of occult cervical metastases and regional failure in multivariate analyses incorporating tumor thickness, but not DOI . In addition, PNI has been associated with worse DSS for stage I/II oral tongue SCC on multivariate analysis in a model which did not incorporate tumor thickness or DOI . In a recent multivariate analysis, PNI was associated with worse OS, which incorporated AJCC 8th edition T staging into the model (which therefore did necessarily stratify by DOI).…”

Section: Discussionmentioning

confidence: 99%

Beyond Depth of Invasion: Adverse Pathologic Tumor Features in Early Oral Tongue Squamous Cell Carcinoma

et al. 2019

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Objective In small (≤2 cm) oral tongue squamous cell carcinoma (OTSCC), we sought to clarify the contribution of pathologic features including perineural invasion (PNI), lymphovascular invasion (LVI), and worst pattern of invasion‐5 (WPOI‐5) to clinical outcomes relative to tumor depth of invasion (DOI) of > or ≤ 4 mm. Methods Cases of ≤2 cm OTSCC treated surgically between 2000 and 2017 at an academic cancer center were reviewed, with retrospective pathologic slide review of DOI, LVI, PNI, and WPOI‐5. Primary outcome measures included occult nodal positivity, 2‐year locoregional recurrence (LRR), disease‐specific survival (DSS), and overall survival (OS). Results One hundred tumors were included in analyses; 50 had DOI ≤ 4 mm, while 50 had DOI > 4 mm. When DOI was ≤4 mm, the presence of PNI, LVI, or WPOI‐5 was not associated with higher rates of occult cervical metastasis, LRR, or OS. When DOI was >4 mm, there was no difference in rates of occult cervical metastasis or LRR with each feature. On multivariate analysis, only the presence of two or more adverse features was associated with higher LRR (OR 5.7, P = .01) and worse DSS (HR 6.5, P = .02). Conclusion The rate of occult cervical metastases in small (≤2 cm) OTSCC when DOI is ≤4 mm is very low even when PNI, LVI, or WPOI‐5 is present, and 2‐year LRR is no different. When DOI is >4 mm, the strongest predictor of recurrence and survival on multivariate analysis is the presence of two or more features in the tumor. Level of Evidence 4 Laryngoscope, 130:1715–1720, 2020

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Section: Discussionmentioning

confidence: 99%

Beyond Depth of Invasion: Adverse Pathologic Tumor Features in Early Oral Tongue Squamous Cell Carcinoma

et al. 2019

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“…Scientists revealed that the expression of NUDT1 improves the invasion and metastasis of various tumors by activating different enzymes and signaling pathways . The degree of tumor invasion and metastasis largely determines the prognosis of patients with OSCC . In this research, we analyzed the OS and TSS of patients with OSCC and found that the OS and TSS of OSCC patients in high NUDT1 expression group were lower than those in the low NUDT1 expression group, which means the high NUDT1 expression had a poorer prognosis than those with low NUDT1 expression.…”

Section: Discussionmentioning

confidence: 87%

“…[22][23][24] The degree of tumor invasion and metastasis largely determines the prognosis of patients with OSCC. 25 In this research, we analyzed the OS and TSS of patients with OSCC and found that the OS and TSS of OSCC patients in high NUDT1 expression group were lower than those in the low NUDT1 expression group, which means the high NUDT1 expression had a poorer prognosis than those with low NUDT1 expression. Further analysis proved that NUDT1 was an independent prognostic factor for OS and TSS of patients with OSCC.…”

Section: Discussionmentioning

confidence: 91%

NUDT1: A potential independent predictor for the prognosis of patients with oral squamous cell carcinoma

Shen

Zhang

Piao

et al. 2019

J Oral Pathology Medicine

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Objective The current study was aimed to investigate the association of nudix hydrolase 1 (NUDT1) levels with the prognosis of oral squamous cell carcinoma (OSCC) patients. Material and Methods Western immunoblotting and qRT‐PCR were used to detect the protein and mRNA levels of NUDT1 in 31 cases of OSCC and normal tissues. The paraffin‐embedded 62 cases of OSCC and 18 normal tissues were collected, and the pathological alterations were assessed by immunohistochemistry. The prognosis of all patients was followed up. Kaplan‐Meier method was used to analyze the survival rate, and Cox regression was used for multivariate analysis. Results Both the protein and gene levels of NUDT1 were statistically increased (P = .0007 and P < .0001) in the OSCC tissue and had a significant association with the histopathologic grades of OSCC (P < .0001 and P = .0223). Immunohistochemistry detection of NUDT1 in 62 human OSCC tissues and 18 normal control tissues showed that NUDT1 expression was significantly increased in OSCC tissue and showed a strong association with histopathologic grades (P < .0001) and tumor stage (P = .005). Patients with high NUDT1 expression exhibited poorer overall survival rate (OS) and tumor‐specific survival rate (TSS) than those with low NUDT1 expression (P < .0001 and P = .0008), and NUDT1 was independent prognostic factors for OS and TSS (P < .0001 and P < .001). Conclusion The expression level of NUDT1 might be used to predict the prognosis of OSCC patients.

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“…5,6 With the introduction of DOI in the new AJCC staging, there is a concern whether adjuvant radiation should be added based on DOI alone. There is a limited literature on evaluation of LVSI as an isolated prognostic factor and authors are divided in their opinion with some suggesting it to be a poor prognosticator [16][17][18] while others suggest the contrary. Various histopathological factors depth of invasion (DOI), PNI, LVSI, grade of the tumor) have been studied previously that could affect survival outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…15 Similarly, in the present study PNI was not found to be significant prognosticator on multivariate analysis both for recurrences and DSS. There is a limited literature on evaluation of LVSI as an isolated prognostic factor and authors are divided in their opinion with some suggesting it to be a poor prognosticator [16][17][18] while others suggest the contrary. 19 In the present study, it was found that LVSI was a significant prognosticator of DSS both on univariate and multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

Early oral cavity cancer: The prognostic factors and impact of adjuvant radiation on survival

et al. 2019

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Background Early oral cavity cancer has good prognosis but recurrence in them is still not uncommon. There is no general consensus on the prognostic factors and adjuvant therapy that would have a significant impact on survival. Methods A retrospective analysis of early oral cavity cancer patients during the time period 2009‐2017. The data regarding demographics, histopathological features, and recurrence patterns were collected and analyzed. Results Depth of invasion (DOI) was the most important prognostic factor among all the factors analyzed. Further analysis showed that addition of adjuvant radiotherapy for patients with DOI >5 mm did not show survival benefits (P = .73). Another subset analysis of patients with DOI >10 mm also did not show any survival advantage with adjuvant therapy P = .24. Conclusion There is no benefit of adding adjuvant RT in patients with DOI > 5 mm or in patients who were upstaged to T3 based only on DOI.

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Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan

Cited by 62 publications

References 30 publications

Beyond Depth of Invasion: Adverse Pathologic Tumor Features in Early Oral Tongue Squamous Cell Carcinoma

Beyond Depth of Invasion: Adverse Pathologic Tumor Features in Early Oral Tongue Squamous Cell Carcinoma

NUDT1: A potential independent predictor for the prognosis of patients with oral squamous cell carcinoma

Early oral cavity cancer: The prognostic factors and impact of adjuvant radiation on survival

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