Pathological evaluation of hepatic dearterialization in encapsulated hepatocellular carcinoma

Tanaka, Nobutaka; Okamoto, Eizo; Toyosaka, Akihiro; Fujiwara, Shiro

doi:10.1002/jso.2930290413

Cited by 14 publications

(6 citation statements)

References 8 publications

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“…Normal-phase HPLC was used for polar lipids (phospholipids, sphingolipids) and reverse-phase HPLC for neutral lipids (triacylglycerols, diacylglycerols, cholesteryl esters). Total cholesterol and cholesteryl esters were analyzed by HPLC/APCI/MS/MS because these apolar compounds only result in a relatively poor ESI response [ 52 ]. Prior to MS, sperm were separated from SP by density gradient centrifugation and sperm lipids were extracted with chloroform–methanol.…”

Section: Analytical Methods Used To Study the Human Semen Metabolomementioning

confidence: 99%

Metabolomics of Human Semen: A Review of Different Analytical Methods to Unravel Biomarkers for Male Fertility Disorders

Blaurock

Baumann

Grunewald

et al. 2022

IJMS

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Background: Human life without sperm is not possible. Therefore, it is alarming that the fertilizing ability of human spermatozoa is continuously decreasing. The reasons for that are widely unknown, but there is hope that metabolomics-based investigations may be able to contribute to overcoming this problem. This review summarizes the attempts made so far. Methods: We will discuss liquid chromatography–mass spectrometry (LC-MS), gas chromatography (GC), infrared (IR) and Raman as well as nuclear magnetic resonance (NMR) spectroscopy. Almost all available studies apply one of these methods. Results: Depending on the methodology used, different compounds can be detected, which is (in combination with sophisticated methods of bioinformatics) helpful to estimate the state of the sperm. Often, but not in all cases, there is a correlation with clinical parameters such as the sperm mobility. Conclusions: LC-MS detects the highest number of metabolites and can be considered as the method of choice. Unfortunately, the reproducibility of some studies is poor, and, thus, further improvements of the study designs are needed to overcome this problem. Additionally, a stronger focus on the biochemical consequences of the altered metabolite concentrations is also required.

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Section: Analytical Methods Used To Study the Human Semen Metabolomementioning

confidence: 99%

Metabolomics of Human Semen: A Review of Different Analytical Methods to Unravel Biomarkers for Male Fertility Disorders

Blaurock

Baumann

Grunewald

et al. 2022

IJMS

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“…The patient was then positioned as for a right posterolateral thoracotomy. A side-viewing rigid laparoscope and an intraoperative ultrasonographic probe (laparoscopic linear 7.5 MHz; Aloka, Tokyo, Japan) were inserted through a 10 mm disposable laparoscopy port, as reported elsewhere [9]. Under laparoscopic control, the ultrasonographic probe was guided onto the liver surface, and the tumor was localized.…”

Section: Patient Selection Criteriamentioning

confidence: 99%

Microwave Coagulonecrotic Therapy for Hepatocellular Carcinoma

et al. 1996

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The present study reports on the usefulness of microwave coagulonecrotic therapy (MCT) as a treatment option for hepatocellular carcinoma (HCC) with poor hepatic reserve. From June 1992 to March 1995, MCT using a microwave electrode was employed on 8 patients using laparoscopic control and 19 with the open method, and wedge resection (Hx) was applied to the 23 patients. All patients had HCC with poor hepatic reserve. Radiation output was 100 watts with a mean radiation duration of about 30 minutes. The severity of liver dysfunction and the regional characteristics of the tumor (tumor size, multiplicity, portal invasion, tumor depth) were comparable between the MCT and Hx groups. The operative time was significantly shorter for the MCT group than the Hx group. The mean blood loss was 1570 ml in the Hx group but negligible in the MCT group. There was no operative mortality in the MCT group in contrast to 4.3% (1 of 23) in the Hx group. Complications were observed in 11.1% (3 of 27) and 34.8% (8 of 23), respectively, for the MCT and Hx groups. The postoperative total bilirubin had lower values and the start of diet was earlier in the MCT group than the Hx group. The 3-year crude and disease-free survival rates were 86% and 44%, respectively, for patients who underwent MCT, which were comparable to 75% and 14% for those with Hx. MCT can achieve long-term results equivalent to those obtained by wedge resections, but it is less invasive and technically easier. Therefore it can be an alternative option in place of limited resection for HCC with poor hepatic reserve.

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“…Most hepatic metastases of HAS showed tumor necrosis regardless of tumor size. Necrosis can be found even in nodules less than 1cm in diameter, whereas the necrosis rate of HCC is relatively low (10%-40%) [9] . Tumor necrosis is believed to be caused by hypoxia resulting from tumor overgrowth and subsequent necrosis in the tumor center [10] .…”

Section: Discussionmentioning

confidence: 98%

MRI features of hepatic metastasis from hepatoid adenocarcinoma of the stomach: A case report

Yuan

Wang

Liu

et al. 2022

Radiology Case Reports

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Pathological evaluation of hepatic dearterialization in encapsulated hepatocellular carcinoma

Cited by 14 publications

References 8 publications

Metabolomics of Human Semen: A Review of Different Analytical Methods to Unravel Biomarkers for Male Fertility Disorders

Metabolomics of Human Semen: A Review of Different Analytical Methods to Unravel Biomarkers for Male Fertility Disorders

Microwave Coagulonecrotic Therapy for Hepatocellular Carcinoma

MRI features of hepatic metastasis from hepatoid adenocarcinoma of the stomach: A case report

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