Pathological effects of prenatal exposure to a 900 MHz electromagnetic field on the 21-day-old male rat kidney

Abstract

We investigated the effects on kidney tissue of 900 megahertz (MHz) EMF applied during the prenatal period. Pregnant rats were exposed to 900 MHz EMF, 1 h/day, on days 13-21 of pregnancy; no procedure was performed on control group pregnant rats or on mothers or newborns after birth. On postnatal day 21, kidney tissues of male rat pups from both groups were examined by light and electron microscopy. Malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione levels also were investigated. Light microscopy revealed some degenerative changes in the tubule epithelium, small cystic formations in the primitive tubules and large cysts in the cortico-medullary or medullary regions in the experimental group. Electron microscopy revealed a loss of peritubular capillaries and atypical parietal layer epithelial cells in the experimental group. Biochemical analysis showed significantly increased MDA levels in the experimental group and decreased SOD and CAT levels. EMF applied during the prenatal period can caused pathological changes in kidney tissue in 21-day-old male rats owing to oxidative stress and decreased antioxidant enzyme levels.

The Impact of 950mhz Electromagnetic Radiation on the Brain and Liver of Rats and the role of Garlic Treatment

“…The results are in line with previous findings that exposure to radiofrequency raises nitricoxide (NO), induces lipid peroxidation (Ozgur et al, 2010), decrease catalase (Sokolovic et al, 2008 andOdaci et al, 2015), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities (Ozgur et al, 2010 andSepehrimanesh et al, 2017), increase the activity of xanthine oxidase (Sokolovic et al, 2008). The decreased activity of enzyme might be attributed to changes in transcription and protein expression (Friedman et al, 2007).…”

The Effect of Prenatal Exposure to 2.4 GHz Radio Frequency on the Histology and Expression of the osteocalcin and RUNX2 Gene of the Forelimb in an NMRI Mouse

“…8,30 Altered biomarkers of oxidative damage and pathological changes in kidney, spleen and thymus tissues have been demonstrated in newborn rat exposing to 900-MHz EMFs prenatally. 9,30 Moreover, there are several studies regarding whether prenatal exposure to 2.4 GHz radio frequency has beneficial or adverse effects. However, there is no consensus about the standardization of the magnetic field used.…”

“…In animal experiments, there are some studies reporting detrimental effects of gestational exposure of high magnetic fields on testis, 7,8 kidney, 9 ovary, 10 heart, 11 bone and muscle tissue 12 as well as teratogenic and behavioral effects on embryos, [13][14][15][16][17] although there are documents reporting no adverse effect of prenatal exposure of high magnetic fields on embryos. 18,19 Our surveys on available sources revealed that there is still a paucity of molecular studies regarding forelimb development following prenatal exposure of 2.4 GHz EMFs.…”

Effects of long-term pre- and post-natal exposure to 2.45 GHz wireless devices on developing male rat kidney

“…Pre-natal exposure to 900 MHz EMF caused tubular and glomerular developmental abnormalities under the evaluation with transmission electron microscopy, which was shown in a previous study. 11 In our study, both prenatal and post-natal exposure to EMF at 2.45 GHz resulted in high levels of 24-hour urinary NAG in rats.…”