Pathological effects of orally administered estradiol to rainbow trout

Herman, Roger L.; Kincaid, Harold

doi:10.1016/0044-8486(88)90156-1

Cited by 146 publications

(65 citation statements)

References 5 publications

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“…This anabolic effect has been reported in other species of the genus Oreochromis when using another synthetic estrogen (Varadaraj, 1989). Herman and Kincaid (1988) indicate that different metabolic pathways may be involved in both cases. However, in our case this anabolic effect was opposite (inverted) in the two growth stages, with the highest growth observed in the 400 mg kg -1 concentration of EE 2 during the fry stage, while during the post-treatment part of the experiment the 100 mg kg -1 concentration of EE 2 had the best results.…”

Section: Discussionsupporting

confidence: 71%

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Juarez-Juarez¹,

Alcántar‐Vázquez²,

Antonio-Estrada³

et al. 2017

Turk. J. Fish. Aquat. Sci.

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Production of YY-males is one of the most important alternatives to the commercial use of hormones for producing monosex populations in the culture of Nile tilapia. One of the final stages of YY-technology is the feminization of the progeny of XY-females in order to obtain YY-females, which when crossed with YY-males makes possible to obtain populations composed of 100% YY-males. The aim of the study was to evaluate the effects of four concentrations (100, 200, 300, 400 mg kg -1 ) of estrogen 17α-ethinylestradiol (EE 2 ) on the sex ratio, growth, condition factor (CV) and gonadosomatic index (GSI) of the progeny of XY-females. Significant differences were observed in wet weight, total length and CV during the experiment; however, final values in EE 2 -treated groups showed not significant differences with control group. The observed proportion of females deviated significantly from the proportion of females expected in the progeny of XY-females in all groups fed EE 2 ; however, only 90% feminization was attained. The group fed 200 mg kg -1 of EE 2 showed a significantly higher value of GSI in comparison to that observed in the control group. By increasing the concentration of EE 2 it is possible to increase the proportion of females without affecting growth or GSI.

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Section: Discussionsupporting

confidence: 71%

Untitled

Juarez-Juarez¹,

Alcántar‐Vázquez²,

Antonio-Estrada³

et al. 2017

Turk. J. Fish. Aquat. Sci.

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“…The main difference between EE 2 exposed and control fish was the possible induction of the synthesis of estrogen controlled proteins, the main one being VTG. Since VTG is not synthesized under normal conditions in male fish, it could conceivably cause negative effects such as kidney dysfunction leading to death (Herman and Kincaid, 1988). Another factor which might be involved in the decreased fitness status are metabolizing enzymes in the liver such as the cytochrome P450-dependent monooxygenase system.…”

Section: Discussionmentioning

confidence: 99%

Determination of vitellogenin kinetics in male fathead minnows (Pimephales promelas)

et al. 2002

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A lack of knowledge persists concerning the combination of kinetics on protein and mRNA levels of the most commonly used biomarker for estrogenic influences-vitellogenin (VTG). Consequently, male fathead minnows were exposed to 17a-ethinylestradiol (EE 2 ) for 35 days, followed by an equally long depuration period in a flow-through system. VTG mRNA levels reached a plateau after 3 days of exposure, which remained stable until 3 days after EE 2 removal. Control levels were re-attained within 7 days of the depuration phase. VTG protein accumulated in the plasma following a two-phased model. The first phase depicting an exponential increase lasted 15 days and was followed by a saturation phase approaching a plateau of approximately 47 mg VTG/ml plasma. Clearance kinetics could be described by a two-compartment open model, with half-lives of 2.17 and 21.32 days for the a-and b-phases, respectively. In addition, a high VTG protein synthesis rate seemed to adversely affect fitness and mortality of the fish.

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“…Accumulation of esinophilic material was reported in flounder injected with 10 mg/kg E 2 (Zaroogian et al, 2001). Esinophilic material was most probably VTG (Herman and Kincaid, 1988), synthesized under the stimulation of estrogenic chemicals such as EE 2 , and accumulated in various tissues. The hypertrophy and degenerative and necrotic of the tubular epithelia were observed in estrogen treated carp (Schwaiger et al, 2000) and flounder (Zaroogian et al, 2001).…”

Section: Renal Tissuementioning

confidence: 99%

Histological alternation and vitellogenin induction in adult rare minnow (Gobiocypris rarus) after exposure to ethynylestradiol and nonylphenol

Zha¹,

Wang²,

Wang³

et al. 2007

Chemosphere

156

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Adult rare minnow (Gobiocypris rarus) were exposed to 0, 1, 5, and 25 ng/l (nominal concentrations) of 17a-ethynylestradiol (EE 2 ) and 3, 10, and 30 lg/l (nominal concentrations) of 4-nonylphenol (NP) under flow-through conditions for a period of 28 d. Low mortality was observed at 5 and 25 ng/l EE 2 and the growth of fish reduced significantly at 25 ng/l EE 2 compared to controls. However, the gonadosomatic indices (GSI) of male fish were significantly higher in 1 ng/l EE 2 treatments and in 10 and 30 lg/l NP treatments (p < 0.05). Renal somatic indices (RSI) of male fish in EE 2 treatments were significantly higher than those in controls (p < 0.05). In contrast, significantly decreased GSI and RSI of female fish could only be observed in 5 and 25 ng/l EE 2 treatments (p < 0.05). Hepatosomatic indices (HSI) of male fish were significantly higher in 25 ng/l EE 2 treatments. However, significantly increased of HSI of female fish could only be observed in 1 ng/l EE 2 treatments. Plasma vitellogenin (VTG) induction could be observed in males after exposed to different concentrations of EE 2 and NP, and plasma VTG concentrations in females exposed to 5 and 25 ng/l EE 2 were also significantly higher than in controls (p < 0.05). At level higher than 5 ng/l EE 2 or 30 lg/l NP, hepatic tissue and renal tissue impairment of males could be observed. The pathological male liver was associated with a hypertrophy of hepatocytes and damages to cellar structure and accumulated eosinophilic material. Renal tissue showed different pathological effects which was reflected by accumulated eosinophilic material, hemorrhages within the kidney tubules and hypertrophy of the tubular epithelia. Also at these levels of exposure, feminization of male fish could be noticed and parts of males manifested the testis-ova phenomenon. Ovaries of female rare minnow in 25 ng/l EE 2 treatment group were degenerated. Therefore when exposed to EE 2 and NP even at environmental observed concentrations, adverse effects could occur in the reproductive system of adult fishes. The observed hepatic tissue and renal tissue impairment should be due to the induction and accumulation of VTG in organs, especially in males.

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Pathological effects of orally administered estradiol to rainbow trout

Cited by 146 publications

References 5 publications

Untitled

Untitled

Determination of vitellogenin kinetics in male fathead minnows (Pimephales promelas)

Histological alternation and vitellogenin induction in adult rare minnow (Gobiocypris rarus) after exposure to ethynylestradiol and nonylphenol

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