Pathological characteristics, survival, and risk of breast cancer associated with estrogen and xenobiotic metabolism polymorphisms in Mexican women with breast cancer

Martínez-Ramírez, Ollin Celeste; Castro-Hernández, Clementina; Pérez‐Morales, Rebeca; Casas-Ávila, Leonora; Lorena, Ramos-García M. de; Salazar-Piña, Dolores Azucena; Rubio, Julieta

doi:10.1007/s10552-021-01393-6

Cited by 1 publication

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“…In recent years, multiple lines of evidence from both humans and mice have shown a significant role for CYP1B1 enzyme in the cardiovascular system (Conway et al 2009;Kaur-Knudsen et al 2009;Song et al 2016;Li et al 2017;Mikstacka and Dutkiewicz 2021), development of hypertension and associated pathophysiological changes (Malik et al 2012;White et al 2012;Shah et al 2019). Also, CYP1B1 polymorphisms were associated with different types of cancers: Endometrial (Sliwinski et al 2010;Zhang et al 2021), breast (Matyjasik et al 2007;Almeida et al 2021;Martínez-Ramírez et al 2021) and colorectal cancer (Hlavata et al 2010;Trubicka et al 2010). The CYP1B1 Leu432Val polymorphism was also found to be significantly associated with the effect of hormone therapy on bone mineral density and LDL-C in postmenopausal Japanese women (Jinhua et al 2009).…”

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confidence: 99%

Association of Leu432Val (rs1056836) polymorphism of the CYP1B1 gene with lipid profile in hypertensive Slovak women

Falbová

Vorobeľová

Čerňanová

et al. 2022

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Leu432Val (rs1056836) polymorphism of the CYP1B1 gene was examined in relationship with lipid profile in hypertensive Slovak women according to their menopausal status. The entire study sample comprised 255 women suffering from hypertension aged from 39 to 65 years who were recruited from different localities in the western, southern, and middle parts of Slovakia. The participants provided a saliva or blood sample for DNA genotyping and a blood sample for biochemical analysis. The Leu432Val genotypes demonstrated statistically significant associations with all monitored atherogenic indices – total cholesterol-to-HDL-Cholesterol (AI1), Non-HDL-Cholesterol (AI2), LDL-Cholesterol-to-HDL-Cholesterol (AI3), and the logarithm of the ratio of plasma concentration of triglycerides to HDL-cholesterol (AIP log) in hypertensive pre/perimenopausal women. The mean values were significantly lower in women carrying the Val/Val genotype. In early postmenopausal hypertensive women the Leu432Val genotypes were statistically significant and associated with LDL-cholesterol (LDL-C) and AI2. The mean values of LDL-C and AI2 were significantly lower in women carrying the Leu/Leu genotype. In conclusion, the Leu432Val polymorphism may be associated with the atherogenic indices and LDL-C in hypertensive women.

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