Pathological characteristics metastatic carcinoma in the human mandible

Abstract

Based on the large celloidin‐embedded section method, human mandibles from 62 autopsied carcinoma cases were examined histologically to determine the pathological characteristics of any mandibular metaslases. Metastasis was confirmed histologically in 10 (16%) of the 62 cases and was comparatively frequent with gastric and pulmonary carcinomas. The hemopoietic areas in the mandibular marrow seemed to favor the early deposition of tumor cells. These micrometastatic foci seemed to increase in size, spreading to all parts, including the periodontal tissue or anterior part of the mandibular body. Increased hemopoietic activity following lodgement, seemed to play an important role for further metastases. Roentogenographic examination did not seem to be the best method of detecting metastasis.

Metastatic Tumors to the Jaws and Mouth

“…Nevertheless, the incidence of metastatic tumors to the jaws is probably higher than suggested; micrometastatic foci in the jaws were found in 16 % of autopsied carcinoma cases despite the absence of radiologic findings [5]. Because of its rarity and the importance of early detection, the diagnosis is challenging and should be considered in the differential diagnosis of benign common oral inflammatory and reactive lesions [6][7][8][9][10].…”

Métastases mandibulaires : présentation de 8 cas

“…La localisation de la tumeur primitive est une tache d'autant plus difficile que, d'une façon générale, toute tumeur à caractère métastatique peut coloniser la cavité buccale [13]. Les tumeurs primitives s'accompagnant le plus souvent des métastases mandibulaires sont celles du sein, du poumon, du rein, de la thyroïde, de la prostate, du testicule et de la vessie [5,7,13,16,17]. Le neuroblastome et les sarcomes (synovialosarcome, ostéosarcome et sarcome d'Ewing) retrouvés dans notre série sont rarement cités dans les séries publiées [11].…”

“…Selon Hashimoto et al [17], la fréquence des métastases varie selon le type histopathologique et le degré de différen-ciation de la tumeur primitive : la fréquence est plus élevée pour les carcinomes indifférenciés (29 %) et les adénocarci-nomes (20 %), que pour les aux carcinomes épidermoïdes.…”

Metastatic Prostate Carcinoma to the Mandible: Report of a case.

“…This could be attributed to the high content of hematopoietic marrow in the mandible (10). Moreover, a reduced rate of blood flow in the angle of mandible may cause more frequent sedimentation of tumor emboli (11).…”