Pathological changes in the brain associated with fits in dogs

Palmer, Alan M.

doi:10.1136/vr.90.7.167

Cited by 33 publications

(19 citation statements)

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“…Despite many references dealing with idiopathic epilepsy, there are only a few studies on symptomatic epilepsy that are based on large case material (Croft, 1965;Palmer, 1972;Podell et al, 1995). In the present study 240 cases of symptomatic and idiopathic epilepsy in dogs were analysed retrospectively.…”

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Retrospective clinical comparison of idiopathic versus symptomatic epilepsy in 240 dogs with seizures

Pákozdy

Leschnik

Tichy

et al. 2008

Acta Veterinaria Hungarica

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In the present study, 240 cases of dogs with seizures were analysed retrospectively. The aim was to examine the underlying aetiology and to compare primary or idiopathic epilepsy (IE) with symptomatic epilepsy (SE) concerning signalment, history, ictal pattern, clinical and neurological findings. The diagnosis of symptomatic epilepsy was based on confirmed pathological changes in haematology, serum biochemistry, cerebrospinal fluid (CSF) analysis and morphological changes of the brain by CT/MRI or histopathological examination. Seizure aetiologies were classified as idiopathic epilepsy (IE, n = 115) and symptomatic epilepsy (SE, n = 125). Symptomatic epilepsy was mainly caused by intracranial neoplasia (39) and encephalitis (23). The following variables showed significant difference between the IE and SE group: age, body weight, presence of partial seizures, cluster seizures, status epilepticus, ictal vocalisation and neurological deficits. In 48% of the cases, seizures were found to be due to IE, while 16% were due to intracranial neoplasia and 10% to encephalitis. Status epilepticus, cluster seizures, partial seizures, vocalisation during seizure and impaired neurological status were more readily seen with symptomatic epilepsy. If the first seizure occurred between one and five years of age or the seizures occurred during resting condition, the diagnosis was more likely IE than SE.

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confidence: 99%

Retrospective clinical comparison of idiopathic versus symptomatic epilepsy in 240 dogs with seizures

Pákozdy

Leschnik

Tichy

et al. 2008

Acta Veterinaria Hungarica

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“…Despite the frequent occurrence of epilepsy in the dog, brain damage resulting from the convulsive seizures has not been recognized widely in this species. The only report dealing specifically with this subject noted only focal hemorrhage as a result of the convulsions in idiopathic epilepsy (18). In contrast, epileptic brain damage is well recognized in man [7] and in experimentally induced convulsive seizures in laboratory animals [16].…”

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Brain Damage in the Epileptic Beagle Dog

Montgomery

Lee

1983

Vet Pathol

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Abstract. Brain lesions associated with seizures in an epilepsy-prone colony of beagle dogs were studied in 68 dogs which died as a result of the disorder. Approximately 48.5% of the dogs had a relatively specific pattern of acute brain damage on microscopic examination. In all affected areas, there was a triad of lesions consisting of perineuronal and perivascular astrocytic swelling, perineuronal basophilic incrustations, and ischemic cell change in neurons. The most common areas of involvement were the cerebral cortex, basal nuclei, claustrum, amygdala, septal nuclei, dorsal thalamic nuclei, isthmus of the pyriform lobe, and hippocampus. The cerebellum was affected only rarely. In addition, intraneuronal inclusions identical to Lafora's bodies found in myoclonus epilepsy of man were detected in thalamic nuclei of six dogs.

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“…Some authors have reported pathological findings of the dogs with the idiopathic epilepsy [12,15]. Montgomery and Lee have described an acute neuronal damage in many dogs of an epileptic beagle colony [12], and suggested that the cerebral cortex, basal nuclei, claustrum, amygdala, septai nuclei, dorsal thalamic nuclei, isthmus of the pyriform lobe and hippocampus were the most common areas affected.…”

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Oligodendroglial Vacuolar Degeneration in the Bilateral Motor Cortices and Astrocytosis in Epileptic Beagle Dogs.

Morita

Shimada

Ohama

et al. 1999

The Journal of Veterinary Medical Science

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ABSTRACT. We performed a pathologic examination of the brains of three dogs in an epileptic beagle colony. Histologically, all the cases had diffuse astrocytosis in the cerebral cortex and basal ganglia as well as the hippocampus, whereas they showed acute nerve cell change in the hippocampus and some other areas of the cerebrum. One of these animals showed laminar myelin pallor associated with the presence of many vacuoles in the IV to VI layers of the bilateral motor cortices. Most of the vacuoles contained fine granules stained with luxol-fast-blue stain. Ultrastructural examination revealed that some oligodendrocytes and perineuronal satellite oligodendrocytes in the bilateral cerebral motor cortices of the two affected dogs had many vacuoles surrounded by myelin-like lamellar structures. These findings suggest a possibility that astrocytosis in the cerebrum and vacuolar degeneration of oligodendrocytes in the cerebral motor cortex may be, at least in part, related to the occurrence or development of seizures. -KEY WORDS: canine, epilepsy, gliosis, oligodendrocyte.

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Pathological changes in the brain associated with fits in dogs

Cited by 33 publications

References 0 publications

Retrospective clinical comparison of idiopathic versus symptomatic epilepsy in 240 dogs with seizures

Retrospective clinical comparison of idiopathic versus symptomatic epilepsy in 240 dogs with seizures

Brain Damage in the Epileptic Beagle Dog

Oligodendroglial Vacuolar Degeneration in the Bilateral Motor Cortices and Astrocytosis in Epileptic Beagle Dogs.

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