Pathological changes in human malignant carcinoma treated with high-intensity focused ultrasound

Wu, Feng; Chen, Wenzhi; Bai, Jing; Zhang, Jianzhong; Wang, Zhilong; Zhu, Hui; Wang, Zhibiao

doi:10.1016/s0301-5629(01)00389-1

Cited by 345 publications

(180 citation statements)

References 40 publications

Supporting

Mentioning

172

Contrasting

Unclassified

Order By: Relevance

“…Our previous studies indicated that these hyperechoic zones corresponded well to the extent of coagulative necrosis, and that there was a close relationship between the extent of necrosis as measured by gross examination and the hyperechoic extent measured on the US image immediately after FUS in both in vivo and in vitro tissues (Wang et al, 1997;Wu et al, 1998Wu et al, , 2000Wu et al, , 2001bBai et al, 1999). In the clinical treatment of patients with breast cancer, we also found that the hyperechogenic regions were regular in shape and size, and conformed to the extent of coagulative necrosis induced by HIFU ablation (Liu et al, 1998;Cao et al, 2001;Wu et al, 2001;Zhou et al, 2001). Although the mechanism for tissue grey-scale change is still unclear, US effects on tissue such as heating and cavitation are involved in the formation of coagulative necrosis, and real-time diagnostic US guidance is seen to be useful in the detection of the coagulative necrosis of target tissue during HIFU procedures.…”

Section: Discussionsupporting

confidence: 52%

“…In clinical applications, real-time imaging modalities including both US (Vallancien et al, 1996;Beerlage et al, 1999;Chapelon et al, 1999;Gelet et al, 1999;Wu et al, 2001aWu et al, , 2002Uchida et al, 2002) and MRI Hynynen et al, 2001) can guide HIFU ablation of solid tumours. These imaging techniques have been used for targeting the lesion to be treated, monitoring the therapeutic procedure, assessing the thermal effects on target tissue, and controlling the ultrasonic energy.…”

Section: Discussionmentioning

confidence: 99%

“…As described in detail previously (Wu et al, 2001a(Wu et al, , 2002, the HIFU therapeutic system used in this clinical trial of breast cancer treatment principally consists of a diagnostic US device, units for computer automatic control, six-direction movement, and a therapeutic planning system, a US generator, integrated US therapy transducers, and a degassed water circulation unit (see Figure 1). The therapeutic US beam is produced by a 12-cm diameter PZT-4 piezo-ceramic transducer with a focal length of 90 mm, operating at a frequency of 1.6 MHz.…”

Section: Hifu Therapeutic Systemmentioning

confidence: 99%

See 2 more Smart Citations

A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer

et al. 2003

View full text Add to dashboard Cite

High-intensity focused ultrasound (HIFU) is a noninvasive treatment that induces complete coagulative necrosis of a tumour at depth through the intact skin. This study was to explore the possibility of using HIFU for the treatment of patients with localised breast cancer in a controlled clinical trial. A total of 48 women with biopsy-proven breast cancer (T 1 -2 , N 0 -2 , M 0 ) were randomised to the control group in which modified radical mastectomy was performed, and the HIFU group in which an extracorporeal HIFU ablation of breast cancer was followed by modified radical mastectomy. Short-term follow-up, pathologic and immunohistochemical stains were performed to assess the therapeutic effects on tumour and complications of HIFU. The results showed that no severe side effect was observed in the HIFU-treated patients. Pathologic findings revealed that HIFU-treated tumour cells underwent complete coagulative necrosis, and tumour vascular vessels were severely damaged. Immunohistochemical staining showed that no expression of PCNA, MMP-9, and CD44v6 was detected within the treated tumour cells in the HIFU group, indicating that the treated tumour cells lost the abilities of proliferation, invasion, and metastasis. It is concluded that, as a noninvasive therapy, HIFU could be effective, safe, and feasible in the extracorporeal treatment of localised breast cancer.

show abstract

Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Hifu Therapeutic Systemmentioning

confidence: 99%

See 1 more Smart Citation

A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Due to the ultrasonic energy accumulation and deposition on the ribs, necrosis was previously reported to occur in all the layers of subcutaneous, costal and intercostal tissue following HIFU treatment. In that study, aseptic necrosis was prevented from spreading to the superficial skin by various treatments and nursing, thus avoiding skin ulceration and cellulitis of the necrotic subcutaneous tissue (17). In the present patient, the necrotic subcutaneous tissue was absorbed, which led to thinning of the chest wall structure and resulted in the occurrence of chest wall hernia.…”

Section: Discussionmentioning

confidence: 84%

“…In addition, multidrug resistant cancer cells and those in G0 phase are also sensitive to HIFU treatment. Furthermore, HIFU is able to stimulate the body's anti-tumor immune response subsequent to the procedure (17). HIFU is considered a superior treatment in terms of controlling tumor progression and prolonging survival, due to its advantages, which include minimal trauma, no risk of radiation and repeatable modality (18).…”

Section: Discussionmentioning

confidence: 99%

Chest wall hernia induced by high intensity focused ultrasound treatment of unresectable massive hepatocellular carcinoma: A case report

Chen

Teng

Chen³

2016

Oncology Letters

View full text Add to dashboard Cite

Abstract. In the present study, a case of unresectable massive hepatocellular carcinoma (HCC) treated with high intensity focused ultrasound (HIFU) alone is reported. Although the treatment induced chest wall hernia, its efficacy in treating the HCC was demonstrated. The medical records of a patient with an unresectable massive tumor that was effectively treated with serial HIFU ablation were retrospectively studied. Chest wall hernia was detected as a complication of the HIFU treatment, which has not been reported thus far in the literature. The patient has survived for 44 months since the first diagnosis in September 2010. Treatment resulted in partial remission of the tumor, pain relief, decreased levels of alpha-fetoprotein and chest wall hernia, as a complication. Therefore, HIFU may be an effective approach for the treatment of unresectable HCC, although it may occasionally cause complications.

show abstract

Biomedical Engineering

Tatroe

Blanchard

1999

Wiley Encyclopedia of Electrical and Electronics Engineering

View full text Add to dashboard Cite

List of figuresFigure Page 2.1 The Biliary system. The figure shows the liver location in the abdominal cavity. 2.2The Anatomy of the Kidney 2.3 The Front View of Urinary Tract. The figure shows the kidneys' location in the abdominal cavity. 2.4The Anatomy of the Pancreas 2. 5 The anatomy of thyroid. The figure shows the thyroid location. 2.6The brain is composed of three parts, the cortex the brain stem the basal ganglia the cerebellum 2.7The brain is divided into several lobes, the frontal, the parietal, the temporal and occipital 3.1 A cross-section of an ultrasonic transducer 3.2 A diagram of a spherical HIFU Transducer with focal length of 100mm. 3.3 A photo of a typical HIFU Transducer. 3.4 How the ablation causes necrosis of tissue at the targeted area. 5.1 Block diagram of high intensity focused ultrasound (HIFU) system with the MRI guidance. This diagram shows the arrangement of the devices used in the HIFU system 5.2 Setup of the actual devices used for the HIFU system with the MRI guidance (The positioning device shown is the third version) 5.3 Diagram of the mechanism of the ultrasonic motor 5.4 Traveling Wave Formation 5.5 Inside structure of USM (USR60-S4) 5.6 A photo of piezoelectric ultrasonic motor by Shinsen USR60E3N 5.7 A photo of dedicated driver for Shinsei USR60 series, Shinsei D6060E. 5.8 Basic connection diagram of the dedicated driver for Shinsei USR60 series, Shinsei D6060E5.9 Wiring diagram of the motor drivers for 3 degrees of freedom positioning device. 5.10The photograph shows the cavitation detector. 5.11The photograph shows the MRI compatible camera 6.1 Corner part used to support the rods and the pulleys. This part is also used to support the different stages of the robot. 6.2The brass rod used to support and guide the surface plates of the stages X, Y and Z. 6.3Position of the brass screw which is used to mount the rod on the angular part. 6.4The brass screws used to mount the parts of the positioning device. 6.5 Brass rod mounted on two angular parts which are attached on the base of the positioning device. 6.6Diagrams and photos of surface plates of the base, X-Stage and Y-Stage. 6.7Pulleys, timing belt, and the piezoelectric ultrasonic motor attached on the base with an angular part which is driving the timing belt to achieve the motion of a surface plate of the X-axis. 6.8The pulleys on the other end of the timing belt hold with two angular parts.6.9 Top view of the base with the brass rods that support and guide the Xaxis plate. The timing belt is mounted on the X-axis plate (not shown here) with a brass screw. 6.10The angular parts attached at the bottom of the X-axis plate are sliding along the brass rod which acts as a support and guide.6.11 Drawings of the various mechanical stages of the positioning device. 6.12 Schematic of the robot showing all of its stages. 6.13Photograph of the complete positioning device. 6.14 Coupling methods, A. In vitro or in vivo (tissue outside the water container). B. In vitro (tissue inside the water container).7.1 CAD design and photograp...

show abstract

Pathological changes in human malignant carcinoma treated with high-intensity focused ultrasound

Cited by 345 publications

References 40 publications

A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer

A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer

Chest wall hernia induced by high intensity focused ultrasound treatment of unresectable massive hepatocellular carcinoma: A case report

Biomedical Engineering

Contact Info

Product

Resources

About